ICD-10-CM Section · D55-D59
Hemolytic anemias
96 codes in this section
96
Total Codes
79
Billable
17
Header (Non-Billable)
5
Top-Level Codes
About Section D55-D59
Section D55-D59 (D55-D59) covers hemolytic anemias. It sits within the Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism chapter (D50-D89). This section contains 96 ICD-10-CM codes, 79 billable diagnoses you can submit on a claim, and 17 non-billable header codes used to organize the hierarchy.
Codes are organized below by 3-character root. Click the root to see all subcodes underneath it, or click any individual code for full coverage data, payer policies, and linked CPT procedures.
Codes in D55-D59
Grouped by 3-character root code. Click any code for full detail.
D55
Anemia due to enzyme disorders
8 subcodes
| D55.0 | Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency | Billable |
| D55.1 | Anemia due to other disorders of glutathione metabolism | Billable |
| D55.2 | Anemia due to disorders of glycolytic enzymes | Header |
| D55.21 | Anemia due to pyruvate kinase deficiency | Billable |
| D55.29 | Anemia due to other disorders of glycolytic enzymes | Billable |
| D55.3 | Anemia due to disorders of nucleotide metabolism | Billable |
| D55.8 | Other anemias due to enzyme disorders | Billable |
| D55.9 | Anemia due to enzyme disorder, unspecified | Billable |
D56
Thalassemia
8 subcodes
| D56.0 | Alpha thalassemia | Billable |
| D56.1 | Beta thalassemia | Billable |
| D56.2 | Delta-beta thalassemia | Billable |
| D56.3 | Thalassemia minor | Billable |
| D56.4 | Hereditary persistence of fetal hemoglobin [HPFH] | Billable |
| D56.5 | Hemoglobin E-beta thalassemia | Billable |
| D56.8 | Other thalassemias | Billable |
| D56.9 | Thalassemia, unspecified | Billable |
D57
Sickle-cell disorders
52 subcodes
| D57.0 | Hb-SS disease with crisis | Header |
| D57.00 | Hb-SS disease with crisis, unspecified | Billable |
| D57.01 | Hb-SS disease with acute chest syndrome | Billable |
| D57.02 | Hb-SS disease with splenic sequestration | Billable |
| D57.03 | Hb-SS disease with cerebral vascular involvement | Billable |
| D57.04 | Hb-SS disease with dactylitis | Billable |
| D57.09 | Hb-SS disease with crisis with other specified complication | Billable |
| D57.1 | Sickle-cell disease without crisis | Billable |
| D57.2 | Sickle-cell/Hb-C disease | Header |
| D57.20 | Sickle-cell/Hb-C disease without crisis | Billable |
| D57.21 | Sickle-cell/Hb-C disease with crisis | Header |
| D57.211 | Sickle-cell/Hb-C disease with acute chest syndrome | Billable |
| D57.212 | Sickle-cell/Hb-C disease with splenic sequestration | Billable |
| D57.213 | Sickle-cell/Hb-C disease with cerebral vascular involvement | Billable |
| D57.214 | Sickle-cell/Hb-C disease with dactylitis | Billable |
| D57.218 | Sickle-cell/Hb-C disease with crisis with other specified complication | Billable |
| D57.219 | Sickle-cell/Hb-C disease with crisis, unspecified | Billable |
| D57.3 | Sickle-cell trait | Billable |
| D57.4 | Sickle-cell thalassemia | Header |
| D57.40 | Sickle-cell thalassemia without crisis | Billable |
| D57.41 | Sickle-cell thalassemia, unspecified, with crisis | Header |
| D57.411 | Sickle-cell thalassemia, unspecified, with acute chest syndrome | Billable |
| D57.412 | Sickle-cell thalassemia, unspecified, with splenic sequestration | Billable |
| D57.413 | Sickle-cell thalassemia, unspecified, with cerebral vascular involvement | Billable |
| D57.414 | Sickle-cell thalassemia, unspecified, with dactylitis | Billable |
| D57.418 | Sickle-cell thalassemia, unspecified, with crisis with other specified complication | Billable |
| D57.419 | Sickle-cell thalassemia, unspecified, with crisis | Billable |
| D57.42 | Sickle-cell thalassemia beta zero without crisis | Billable |
| D57.43 | Sickle-cell thalassemia beta zero with crisis | Header |
| D57.431 | Sickle-cell thalassemia beta zero with acute chest syndrome | Billable |
| D57.432 | Sickle-cell thalassemia beta zero with splenic sequestration | Billable |
| D57.433 | Sickle-cell thalassemia beta zero with cerebral vascular involvement | Billable |
| D57.434 | Sickle-cell thalassemia beta zero with dactylitis | Billable |
| D57.438 | Sickle-cell thalassemia beta zero with crisis with other specified complication | Billable |
| D57.439 | Sickle-cell thalassemia beta zero with crisis, unspecified | Billable |
| D57.44 | Sickle-cell thalassemia beta plus without crisis | Billable |
| D57.45 | Sickle-cell thalassemia beta plus with crisis | Header |
| D57.451 | Sickle-cell thalassemia beta plus with acute chest syndrome | Billable |
| D57.452 | Sickle-cell thalassemia beta plus with splenic sequestration | Billable |
| D57.453 | Sickle-cell thalassemia beta plus with cerebral vascular involvement | Billable |
| D57.454 | Sickle-cell thalassemia beta plus with dactylitis | Billable |
| D57.458 | Sickle-cell thalassemia beta plus with crisis with other specified complication | Billable |
| D57.459 | Sickle-cell thalassemia beta plus with crisis, unspecified | Billable |
| D57.8 | Other sickle-cell disorders | Header |
| D57.80 | Other sickle-cell disorders without crisis | Billable |
| D57.81 | Other sickle-cell disorders with crisis | Header |
| D57.811 | Other sickle-cell disorders with acute chest syndrome | Billable |
| D57.812 | Other sickle-cell disorders with splenic sequestration | Billable |
| D57.813 | Other sickle-cell disorders with cerebral vascular involvement | Billable |
| D57.814 | Other sickle-cell disorders with dactylitis | Billable |
| D57.818 | Other sickle-cell disorders with crisis with other specified complication | Billable |
| D57.819 | Other sickle-cell disorders with crisis, unspecified | Billable |
D58
Other hereditary hemolytic anemias
5 subcodes
| D58.0 | Hereditary spherocytosis | Billable |
| D58.1 | Hereditary elliptocytosis | Billable |
| D58.2 | Other hemoglobinopathies | Billable |
| D58.8 | Other specified hereditary hemolytic anemias | Billable |
| D58.9 | Hereditary hemolytic anemia, unspecified | Billable |
D59
Acquired hemolytic anemia
18 subcodes
| D59.0 | Drug-induced autoimmune hemolytic anemia | Billable |
| D59.1 | Other autoimmune hemolytic anemias | Header |
| D59.10 | Autoimmune hemolytic anemia, unspecified | Billable |
| D59.11 | Warm autoimmune hemolytic anemia | Billable |
| D59.12 | Cold autoimmune hemolytic anemia | Billable |
| D59.13 | Mixed type autoimmune hemolytic anemia | Billable |
| D59.19 | Other autoimmune hemolytic anemia | Billable |
| D59.2 | Drug-induced nonautoimmune hemolytic anemia | Billable |
| D59.3 | Hemolytic-uremic syndrome | Header |
| D59.30 | Hemolytic-uremic syndrome, unspecified | Billable |
| D59.31 | Infection-associated hemolytic-uremic syndrome | Billable |
| D59.32 | Hereditary hemolytic-uremic syndrome | Billable |
| D59.39 | Other hemolytic-uremic syndrome | Billable |
| D59.4 | Other nonautoimmune hemolytic anemias | Billable |
| D59.5 | Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] | Billable |
| D59.6 | Hemoglobinuria due to hemolysis from other external causes | Billable |
| D59.8 | Other acquired hemolytic anemias | Billable |
| D59.9 | Acquired hemolytic anemia, unspecified | Billable |
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Verified against the CMS 2026 code set on May 31, 2026.
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