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ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 D81.819

Billable / Specific

Biotin-dependent carboxylase deficiency, unspecified

D81

Block

1

Synonyms

29

LCDs

6

Payer Policies

2

Linked CPTs

About ICD-10-CM D81.819

ICD-10-CM code D81.819 represents Biotin-dependent carboxylase deficiency, unspecified. This is a billable/specific code in the Blood and Blood-forming Organs chapter (block D81). The 2026 edition of ICD-10-CM D81.819 became effective on October 1, 2025.

Inclusion Terms / Approximate Synonyms

Clinical terms and conditions classified under D81.819. Per CMS ICD-10-CM Tabular 2026.

Multiple carboxylase deficiency, unspecified

Medicare LCD Coverage for D81.819

Local Coverage Determinations (LCDs) from CMS MACs that list D81.819 as a covered diagnosis.

29 LCDs

Showing top 10 of 29 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function

Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered

CPT 82306 →

CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function

Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered

CPT 82607 →

CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function

Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered

CPT 82746 →

CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function

Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered

CPT 85385 →

CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function

Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered

CPT 83090 →

CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function

Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered

CPT 82652 →

CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function

Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered

CPT 84207 →

CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function

Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered

CPT 86352 →

CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function

Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered

CPT 82379 →

CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function

Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered

CPT 83698 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing D81.819.

6 policies

5 Medicare

Billing and Coding: Routine Foot Care

Policy ID: ART-52996

Billing and Coding: Assays for Vitamins and Metabolic Function

Policy ID: ART-56416

Billing and Coding: Routine Foot Care

Policy ID: ART-57188

Billing and Coding: Vitamin B<sub>12</sub> Injections

Policy ID: ART-57755

Billing and Coding: Multiplex Gastrointestinal Pathogen Panel (GPP) Tests for Acute Gastroenteritis (AGE)

Policy ID: ART-58963

1 Aetna

Homocysteine Testing

Policy ID: CPB-0763

CPT Codes Commonly Billed with D81.819

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

2 linkages

J3420 CMS LCD: Billing and Coding: Vitamin B<sub>12</sub> Injections CMS LCD
J3425 CMS LCD: Billing and Coding: Vitamin B<sub>12</sub> Injections CMS LCD

Convert D81.819 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10	ICD-9	Mapping Flags
D81.819	2662	10000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

Codes Adjacent To D81.819

Other codes in section D80-D89 (Certain disorders involving the immune mechanism).

D80 Immunodeficiency with predominantly antibody defects (non-billable) D80.0 Hereditary hypogammaglobulinemia D80.1 Nonfamilial hypogammaglobulinemia D80.2 Selective deficiency of immunoglobulin A [IgA] D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses D80.4 Selective deficiency of immunoglobulin M [IgM] D80.5 Immunodeficiency with increased immunoglobulin M [IgM] D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia D80.7 Transient hypogammaglobulinemia of infancy D80.8 Other immunodeficiencies with predominantly antibody defects D80.9 Immunodeficiency with predominantly antibody defects, unspecified D81 Combined immunodeficiencies (non-billable) D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers D81.3 Adenosine deaminase [ADA] deficiency (non-billable) D81.30 Adenosine deaminase deficiency, unspecified D81.31 Severe combined immunodeficiency due to adenosine deaminase deficiency D81.32 Adenosine deaminase 2 deficiency D81.39 Other adenosine deaminase deficiency

ICD-10 D81.819, Billing FAQ

Is ICD-10 code D81.819 billable? +

Yes, D81.819 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What other names or terms map to D81.819? +

ICD-10 D81.819 includes: Multiple carboxylase deficiency, unspecified.

What CPT codes are commonly billed with D81.819? +

Procedures frequently paired with D81.819 include: J3420, J3425.

What ICD-9 codes does D81.819 map to? +

Per CMS GEMs, D81.819 maps to ICD-9 codes: 2662. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on July 16, 2026.

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