ICD-10 D81
Non-Billable HeaderCombined immunodeficiencies
About ICD-10-CM D81
ICD-10-CM code D81 represents Combined immunodeficiencies. This is a non-billable header code in the Blood and Blood-forming Organs chapter (block D81). The 2026 edition of ICD-10-CM D81 became effective on October 1, 2025. Non-billable codes cannot be used as a primary or secondary diagnosis on a claim, use a more specific child code instead.
Type 1 Excludes
Pure excludes, these codes can never be coded together with D81. The conditions are mutually exclusive (e.g., congenital vs acquired forms).
- autosomal recessive agammaglobulinemia (Swiss type) (D80.0)
Medicare LCD Coverage for D81
Local Coverage Determinations (LCDs) from CMS MACs that list D81 as a covered diagnosis.
This doesn't mean the code isn't covered, it means no MAC has issued a Local Coverage Determination naming this specific code. Coverage may still apply under National Coverage Determinations or general medical-necessity rules.
Commercial Payer Coverage
Coverage policies from major commercial payers referencing D81.
Our payer policy database covers Aetna, Cigna, Anthem, BCBS, Humana, and Medicare Advantage plans, but D81 doesn't currently appear in any indexed policy. The code may still be covered under standard plan benefits.
CPT Codes Commonly Billed with D81
Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.
We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.
Codes Adjacent To D81
Other codes in section D80-D89 (Certain disorders involving the immune mechanism).
ICD-10 D81, Billing FAQ
Is ICD-10 code D81 billable? +
No, D81 is a non-billable header code. Use a more specific child code from block D81 when submitting claims.
What codes are Type 1 Excludes for D81? +
Type 1 Excludes (never code together with D81): autosomal recessive agammaglobulinemia (Swiss type) (D80.0)
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on June 1, 2026.
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