ICD-10 D81.32
Billable / Specific HCC v28: 47 CCAdenosine deaminase 2 deficiency
About ICD-10-CM D81.32
ICD-10-CM code D81.32 represents Adenosine deaminase 2 deficiency. This is a billable/specific code in the Blood and Blood-forming Organs chapter (block D81). The 2026 edition of ICD-10-CM D81.32 became effective on October 1, 2025.
Coding Tips for D81.32
Specialist guidance from the PayerReady Medical Coding Team. Specificity warnings, HCC capture rules, sequencing notes.
D81.32 is a CMS-HCC v28 risk-adjustment code (category 47). To count for the patient Risk Adjustment Factor (RAF), document the diagnosis with MEAT language each calendar year: Monitored, Evaluated, Assessed, Treated. A diagnosis on the problem list alone does not satisfy CMS RADV audit standards. Include the diagnosis in the assessment with current status and current treatment plan.
D81.32 is designated CC for MS-DRG grouping. On inpatient claims, this code can shift the DRG to the with-CC variant when documented as a present-on-admission secondary diagnosis. Hospital CDI programs flag CC opportunities during chart review. Failure to capture this code may leave 30 to 80 percent of the inpatient stay revenue unrealized.
Inclusion Terms / Approximate Synonyms
Clinical terms and conditions classified under D81.32. Per CMS ICD-10-CM Tabular 2026.
- ADA2 deficiency
- Adenosine deaminase deficiency type 2
Coding Notes
Code Also
- , if applicable, any associated manifestations, such as:
- polyarteritis nodosa (M30.0)
- stroke (I63.-)
Medicare Advantage HCC Impact
Capture this diagnosis annually for accurate risk adjustment. Missed HCC captures are the #1 revenue leak in Medicare Advantage risk programs.
Inpatient DRG Impact, CC
codes Adenosine deaminase 2 deficiency. As a Complication/Comorbidity (CC), this contributes to DRG severity adjustment when documented alongside the principal diagnosis.
Medicare LCD Coverage for D81.32
Local Coverage Determinations (LCDs) from CMS MACs that list D81.32 as a covered diagnosis.
Showing top 10 of 584 total . Click a CPT for full coverage scope.
Commercial Payer Coverage
Coverage policies from major commercial payers referencing D81.32.
5 Medicare
CPT Codes Commonly Billed with D81.32
Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.
Codes Adjacent To D81.32
Other codes in section D80-D89 (Certain disorders involving the immune mechanism).
ICD-10 D81.32, Billing FAQ
Is ICD-10 code D81.32 billable? +
Yes, D81.32 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.
What other names or terms map to D81.32? +
ICD-10 D81.32 includes: ADA2 deficiency; Adenosine deaminase deficiency type 2.
Does D81.32 affect Medicare Advantage HCC risk adjustment? +
Yes. D81.32 maps to CMS-HCC v28 category 47. Capture this diagnosis annually for accurate Medicare Advantage risk score.
Is D81.32 a CC or MCC for inpatient DRG? +
Yes, this code is designated as CC. Documenting as a secondary diagnosis on inpatient claims can shift the DRG to a higher-weighted category.
What CPT codes are commonly billed with D81.32? +
Procedures frequently paired with D81.32 include: 87812, 87428, 87913.
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on May 31, 2026.
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