ICD-10 D80.8
Billable / Specific HCC v28: 47 CCOther immunodeficiencies with predominantly antibody defects
About ICD-10-CM D80.8
ICD-10-CM code D80.8 represents Other immunodeficiencies with predominantly antibody defects. This is a billable/specific code in the Blood and Blood-forming Organs chapter (block D80). The 2026 edition of ICD-10-CM D80.8 became effective on October 1, 2025.
Coding Tips for D80.8
Specialist guidance from the PayerReady Medical Coding Team. Specificity warnings, HCC capture rules, sequencing notes.
D80.8 is a CMS-HCC v28 risk-adjustment code (category 47). To count for the patient Risk Adjustment Factor (RAF), document the diagnosis with MEAT language each calendar year: Monitored, Evaluated, Assessed, Treated. A diagnosis on the problem list alone does not satisfy CMS RADV audit standards. Include the diagnosis in the assessment with current status and current treatment plan.
D80.8 is designated CC for MS-DRG grouping. On inpatient claims, this code can shift the DRG to the with-CC variant when documented as a present-on-admission secondary diagnosis. Hospital CDI programs flag CC opportunities during chart review. Failure to capture this code may leave 30 to 80 percent of the inpatient stay revenue unrealized.
Inclusion Terms / Approximate Synonyms
Clinical terms and conditions classified under D80.8. Per CMS ICD-10-CM Tabular 2026.
- Kappa light chain deficiency
Medicare Advantage HCC Impact
Capture this diagnosis annually for accurate risk adjustment. Missed HCC captures are the #1 revenue leak in Medicare Advantage risk programs.
Inpatient DRG Impact, CC
codes Other immunodeficiencies with predominantly antibody defects. As a Complication/Comorbidity (CC), this contributes to DRG severity adjustment when documented alongside the principal diagnosis.
Medicare LCD Coverage for D80.8
Local Coverage Determinations (LCDs) from CMS MACs that list D80.8 as a covered diagnosis.
Showing top 10 of 713 total . Click a CPT for full coverage scope.
Commercial Payer Coverage
Coverage policies from major commercial payers referencing D80.8.
5 Medicare
CPT Codes Commonly Billed with D80.8
Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.
- 87507 CMS LCD: Billing and Coding: Gastrointestinal Pathogen (GIP) Panels Utilizing Multiplex Nucleic Acid Amplification Techniques (NAATs) CMS LCD
- 87505 CMS LCD: Billing and Coding: Gastrointestinal Pathogen (GIP) Panels Utilizing Multiplex Nucleic Acid Amplification Techniques (NAATs) CMS LCD
- 87506 CMS LCD: Billing and Coding: Gastrointestinal Pathogen (GIP) Panels Utilizing Multiplex Nucleic Acid Amplification Techniques (NAATs) CMS LCD
- J1551 CMS LCD: Billing and Coding: Immune Globulin CMS LCD
- J1559 CMS LCD: Billing and Coding: Immune Globulin CMS LCD
- J1576 CMS LCD: Billing and Coding: Immune Globulin CMS LCD
- J1558 CMS LCD: Billing and Coding: Immune Globulin CMS LCD
- J1555 CMS LCD: Billing and Coding: Immune Globulin CMS LCD
- 87812 CMS LCD: Billing and Coding: Respiratory Pathogen Panel Testing CMS LCD
- 87428 CMS LCD: Billing and Coding: Respiratory Pathogen Panel Testing CMS LCD
Convert D80.8 to ICD-9-CM
Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.
| ICD-10 | ICD-9 | Mapping Flags |
|---|---|---|
| D80.8 | 27909 | 10000 |
Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).
Codes Adjacent To D80.8
Other codes in section D80-D89 (Certain disorders involving the immune mechanism).
ICD-10 D80.8, Billing FAQ
Is ICD-10 code D80.8 billable? +
Yes, D80.8 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.
What other names or terms map to D80.8? +
ICD-10 D80.8 includes: Kappa light chain deficiency.
Does D80.8 affect Medicare Advantage HCC risk adjustment? +
Yes. D80.8 maps to CMS-HCC v28 category 47. Capture this diagnosis annually for accurate Medicare Advantage risk score.
Is D80.8 a CC or MCC for inpatient DRG? +
Yes, this code is designated as CC. Documenting as a secondary diagnosis on inpatient claims can shift the DRG to a higher-weighted category.
What CPT codes are commonly billed with D80.8? +
Procedures frequently paired with D80.8 include: 87507, 87505, 87506, J1551, J1559.
What ICD-9 codes does D80.8 map to? +
Per CMS GEMs, D80.8 maps to ICD-9 codes: 27909. Useful for legacy data review and historical claim analysis.
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on June 1, 2026.
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