ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 D49.9

Billable / Specific

Neoplasm of unspecified behavior of unspecified site

D49
Block
0
Synonyms
98
LCDs
11
Payer Policies
0
Linked CPTs

About ICD-10-CM D49.9

ICD-10-CM code D49.9 represents Neoplasm of unspecified behavior of unspecified site. This is a billable/specific code in the Neoplasms chapter (block D49). The 2026 edition of ICD-10-CM D49.9 became effective on October 1, 2025.

Medicare LCD Coverage for D49.9

Local Coverage Determinations (LCDs) from CMS MACs that list D49.9 as a covered diagnosis.

98 LCDs

Showing top 10 of 98 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: MolDX: bioTheranostics Cancer TYPE ID� Update
Article ID: 54386, Effective: 2026-02-19 00:00:00, 255 covered, 0 non-covered
CPT 81540 →
CMS LCD: Billing and Coding: Biomarkers for Oncology
Article ID: 52986, Effective: 2025-04-24 00:00:00, 427 covered, 1 non-covered
CPT 81316 →
CMS LCD: Billing and Coding: Biomarkers for Oncology
Article ID: 52986, Effective: 2025-04-24 00:00:00, 427 covered, 1 non-covered
CPT 81357 →
CMS LCD: Billing and Coding: Biomarkers for Oncology
Article ID: 52986, Effective: 2025-04-24 00:00:00, 427 covered, 1 non-covered
CPT 81348 →
CMS LCD: Billing and Coding: Biomarkers for Oncology
Article ID: 52986, Effective: 2025-04-24 00:00:00, 427 covered, 1 non-covered
CPT 81170 →
CMS LCD: Billing and Coding: Biomarkers for Oncology
Article ID: 52986, Effective: 2025-04-24 00:00:00, 427 covered, 1 non-covered
CPT 81275 →
CMS LCD: Billing and Coding: Biomarkers for Oncology
Article ID: 52986, Effective: 2025-04-24 00:00:00, 427 covered, 1 non-covered
CPT 81262 →
CMS LCD: Billing and Coding: Biomarkers for Oncology
Article ID: 52986, Effective: 2025-04-24 00:00:00, 427 covered, 1 non-covered
CPT 81334 →
CMS LCD: Billing and Coding: Biomarkers for Oncology
Article ID: 52986, Effective: 2025-04-24 00:00:00, 427 covered, 1 non-covered
CPT 81206 →
CMS LCD: Billing and Coding: Biomarkers for Oncology
Article ID: 52986, Effective: 2025-04-24 00:00:00, 427 covered, 1 non-covered
CPT 81263 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing D49.9.

11 policies

1 Cigna

Transthoracic Echocardiography in Children - (0523)
Policy ID: MM_0523

5 Medicare

Billing and Coding: Paclitaxel (e.g., Taxol�/Abraxane �)
Policy ID: ART-52450
Billing and Coding: Biomarkers for Oncology
Policy ID: ART-52986
Billing and Coding: MolDX: bioTheranostics Cancer TYPE ID� Update
Policy ID: ART-53101
Billing and Coding: MolDX: bioTheranostics Cancer TYPE ID�
Policy ID: ART-54188
Billing and Coding: MolDX: bioTheranostics Cancer TYPE ID� Update
Policy ID: ART-54386

2 Aetna

Intensity Modulated Radiation Therapy
Policy ID: CPB-0590
Brain Natriuretic Peptide Testing
Policy ID: CPB-0618

CPT Codes Commonly Billed with D49.9

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

No procedure linkages on file for D49.9

We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.

Convert D49.9 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
D49.9 2399 00000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 D49.9, Billing FAQ

Is ICD-10 code D49.9 billable? +

Yes, D49.9 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What ICD-9 codes does D49.9 map to? +

Per CMS GEMs, D49.9 maps to ICD-9 codes: 2399. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on June 1, 2026.

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