ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 D49.1

Billable / Specific

Neoplasm of unspecified behavior of respiratory system

D49
Block
0
Synonyms
169
LCDs
16
Payer Policies
0
Linked CPTs

About ICD-10-CM D49.1

ICD-10-CM code D49.1 represents Neoplasm of unspecified behavior of respiratory system. This is a billable/specific code in the Neoplasms chapter (block D49). The 2026 edition of ICD-10-CM D49.1 became effective on October 1, 2025.

Medicare LCD Coverage for D49.1

Local Coverage Determinations (LCDs) from CMS MACs that list D49.1 as a covered diagnosis.

169 LCDs

Showing top 10 of 169 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64420 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 20561 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64415 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64447 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64448 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64416 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64405 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64454 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64425 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64450 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing D49.1.

16 policies

2 Aetna

Septoplasty and Rhinoplasty - Medical Clinical Policy Bulletins | Aetna
Policy ID: CPB-0005
Videostroboscopy
Policy ID: CPB-0305

5 Medicare

Billing and Coding: Paclitaxel (e.g., Taxol�/Abraxane �)
Policy ID: ART-52450
Oral Antiemetic Drugs (Replacement for Intravenous Antiemetics) - Policy Article
Policy ID: ART-52480
Billing and Coding: Biomarkers for Oncology
Policy ID: ART-52986
Billing and Coding: MolDX: bioTheranostics Cancer TYPE ID� Update
Policy ID: ART-53101
Billing and Coding: MolDX: bioTheranostics Cancer TYPE ID�
Policy ID: ART-54188

CPT Codes Commonly Billed with D49.1

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

No procedure linkages on file for D49.1

We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.

Convert D49.1 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
D49.1 2391 00000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 D49.1, Billing FAQ

Is ICD-10 code D49.1 billable? +

Yes, D49.1 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What ICD-9 codes does D49.1 map to? +

Per CMS GEMs, D49.1 maps to ICD-9 codes: 2391. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on May 31, 2026.

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