Resistance to antimicrobial drugs
24 codes in this section
About Section Z16
Section Z16 (Z16-Z16) covers resistance to antimicrobial drugs. It sits within the Factors influencing health status and contact with health services chapter (Z00-Z99). This section contains 24 ICD-10-CM codes, 19 billable diagnoses you can submit on a claim, and 5 non-billable header codes used to organize the hierarchy.
Codes are organized below by 3-character root. Click the root to see all subcodes underneath it, or click any individual code for full coverage data, payer policies, and linked CPT procedures.
Codes in Z16
Grouped by 3-character root code. Click any code for full detail.
| Z16.1 | Resistance to beta lactam antibiotics | Header |
| Z16.10 | Resistance to unspecified beta lactam antibiotics | Billable |
| Z16.11 | Resistance to penicillins | Billable |
| Z16.12 | Extended spectrum beta lactamase (ESBL) resistance | Billable |
| Z16.13 | Resistance to carbapenem | Billable |
| Z16.19 | Resistance to other specified beta lactam antibiotics | Billable |
| Z16.2 | Resistance to other antibiotics | Header |
| Z16.20 | Resistance to unspecified antibiotic | Billable |
| Z16.21 | Resistance to vancomycin | Billable |
| Z16.22 | Resistance to vancomycin related antibiotics | Billable |
| Z16.23 | Resistance to quinolones and fluoroquinolones | Billable |
| Z16.24 | Resistance to multiple antibiotics | Billable |
| Z16.29 | Resistance to other single specified antibiotic | Billable |
| Z16.3 | Resistance to other antimicrobial drugs | Header |
| Z16.30 | Resistance to unspecified antimicrobial drugs | Billable |
| Z16.31 | Resistance to antiparasitic drug(s) | Billable |
| Z16.32 | Resistance to antifungal drug(s) | Billable |
| Z16.33 | Resistance to antiviral drug(s) | Billable |
| Z16.34 | Resistance to antimycobacterial drug(s) | Header |
| Z16.341 | Resistance to single antimycobacterial drug | Billable |
| Z16.342 | Resistance to multiple antimycobacterial drugs | Billable |
| Z16.35 | Resistance to multiple antimicrobial drugs | Billable |
| Z16.39 | Resistance to other specified antimicrobial drug | Billable |
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on May 31, 2026.
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