ICD-10 Z16.341
Billable / Specific CCResistance to single antimycobacterial drug
About ICD-10-CM Z16.341
ICD-10-CM code Z16.341 represents Resistance to single antimycobacterial drug. This is a billable/specific code in the Factors Influencing Health Status chapter (block Z16). The 2026 edition of ICD-10-CM Z16.341 became effective on October 1, 2025.
Coding Tips for Z16.341
Specialist guidance from the PayerReady Medical Coding Team. Specificity warnings, HCC capture rules, sequencing notes.
Z16.341 is designated CC for MS-DRG grouping. On inpatient claims, this code can shift the DRG to the with-CC variant when documented as a present-on-admission secondary diagnosis. Hospital CDI programs flag CC opportunities during chart review. Failure to capture this code may leave 30 to 80 percent of the inpatient stay revenue unrealized.
Inclusion Terms / Approximate Synonyms
Clinical terms and conditions classified under Z16.341. Per CMS ICD-10-CM Tabular 2026.
- Resistance to antimycobacterial drug NOS
Inpatient DRG Impact, CC
Excl Resistance to single antimycobacterial drug. As a Complication/Comorbidity (CC), this contributes to DRG severity adjustment when documented alongside the principal diagnosis.
Medicare LCD Coverage for Z16.341
Local Coverage Determinations (LCDs) from CMS MACs that list Z16.341 as a covered diagnosis.
This doesn't mean the code isn't covered, it means no MAC has issued a Local Coverage Determination naming this specific code. Coverage may still apply under National Coverage Determinations or general medical-necessity rules.
Commercial Payer Coverage
Coverage policies from major commercial payers referencing Z16.341.
1 Aetna
CPT Codes Commonly Billed with Z16.341
Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.
We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.
Convert Z16.341 to ICD-9-CM
Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.
| ICD-10 | ICD-9 | Mapping Flags |
|---|---|---|
| Z16.341 | V0970 | 00000 |
Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).
Codes Adjacent To Z16.341
Other codes in section Z16 (Resistance to antimicrobial drugs).
ICD-10 Z16.341, Billing FAQ
Is ICD-10 code Z16.341 billable? +
Yes, Z16.341 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.
What other names or terms map to Z16.341? +
ICD-10 Z16.341 includes: Resistance to antimycobacterial drug NOS.
Is Z16.341 a CC or MCC for inpatient DRG? +
Yes, this code is designated as CC. Documenting as a secondary diagnosis on inpatient claims can shift the DRG to a higher-weighted category.
What ICD-9 codes does Z16.341 map to? +
Per CMS GEMs, Z16.341 maps to ICD-9 codes: V0970. Useful for legacy data review and historical claim analysis.
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on May 31, 2026.
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