Malignant neoplasms of digestive organs
69 codes in this section
About Section C15-C26
Section C15-C26 (C15-C26) covers malignant neoplasms of digestive organs. It sits within the Neoplasms chapter (C00-D49). This section contains 69 ICD-10-CM codes, 60 billable diagnoses you can submit on a claim, and 9 non-billable header codes used to organize the hierarchy.
Codes are organized below by 3-character root. Click the root to see all subcodes underneath it, or click any individual code for full coverage data, payer policies, and linked CPT procedures.
Codes in C15-C26
Grouped by 3-character root code. Click any code for full detail.
| C15.3 | Malignant neoplasm of upper third of esophagus | Billable |
| C15.4 | Malignant neoplasm of middle third of esophagus | Billable |
| C15.5 | Malignant neoplasm of lower third of esophagus | Billable |
| C15.8 | Malignant neoplasm of overlapping sites of esophagus | Billable |
| C15.9 | Malignant neoplasm of esophagus, unspecified | Billable |
| C16.0 | Malignant neoplasm of cardia | Billable |
| C16.1 | Malignant neoplasm of fundus of stomach | Billable |
| C16.2 | Malignant neoplasm of body of stomach | Billable |
| C16.3 | Malignant neoplasm of pyloric antrum | Billable |
| C16.4 | Malignant neoplasm of pylorus | Billable |
| C16.5 | Malignant neoplasm of lesser curvature of stomach, unspecified | Billable |
| C16.6 | Malignant neoplasm of greater curvature of stomach, unspecified | Billable |
| C16.8 | Malignant neoplasm of overlapping sites of stomach | Billable |
| C16.9 | Malignant neoplasm of stomach, unspecified | Billable |
| C17.0 | Malignant neoplasm of duodenum | Billable |
| C17.1 | Malignant neoplasm of jejunum | Billable |
| C17.2 | Malignant neoplasm of ileum | Billable |
| C17.3 | Meckel's diverticulum, malignant | Billable |
| C17.8 | Malignant neoplasm of overlapping sites of small intestine | Billable |
| C17.9 | Malignant neoplasm of small intestine, unspecified | Billable |
| C18.0 | Malignant neoplasm of cecum | Billable |
| C18.1 | Malignant neoplasm of appendix | Billable |
| C18.2 | Malignant neoplasm of ascending colon | Billable |
| C18.3 | Malignant neoplasm of hepatic flexure | Billable |
| C18.4 | Malignant neoplasm of transverse colon | Billable |
| C18.5 | Malignant neoplasm of splenic flexure | Billable |
| C18.6 | Malignant neoplasm of descending colon | Billable |
| C18.7 | Malignant neoplasm of sigmoid colon | Billable |
| C18.8 | Malignant neoplasm of overlapping sites of colon | Billable |
| C18.9 | Malignant neoplasm of colon, unspecified | Billable |
| C21.0 | Malignant neoplasm of anus, unspecified | Billable |
| C21.1 | Malignant neoplasm of anal canal | Billable |
| C21.2 | Malignant neoplasm of cloacogenic zone | Billable |
| C21.8 | Malignant neoplasm of overlapping sites of rectum, anus and anal canal | Billable |
| C22.0 | Liver cell carcinoma | Billable |
| C22.1 | Intrahepatic bile duct carcinoma | Billable |
| C22.2 | Hepatoblastoma | Billable |
| C22.3 | Angiosarcoma of liver | Billable |
| C22.4 | Other sarcomas of liver | Billable |
| C22.7 | Other specified carcinomas of liver | Billable |
| C22.8 | Malignant neoplasm of liver, primary, unspecified as to type | Billable |
| C22.9 | Malignant neoplasm of liver, not specified as primary or secondary | Billable |
| C24.0 | Malignant neoplasm of extrahepatic bile duct | Billable |
| C24.1 | Malignant neoplasm of ampulla of Vater | Billable |
| C24.8 | Malignant neoplasm of overlapping sites of biliary tract | Billable |
| C24.9 | Malignant neoplasm of biliary tract, unspecified | Billable |
| C25.0 | Malignant neoplasm of head of pancreas | Billable |
| C25.1 | Malignant neoplasm of body of pancreas | Billable |
| C25.2 | Malignant neoplasm of tail of pancreas | Billable |
| C25.3 | Malignant neoplasm of pancreatic duct | Billable |
| C25.4 | Malignant neoplasm of endocrine pancreas | Billable |
| C25.7 | Malignant neoplasm of other parts of pancreas | Billable |
| C25.8 | Malignant neoplasm of overlapping sites of pancreas | Billable |
| C25.9 | Malignant neoplasm of pancreas, unspecified | Billable |
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on May 31, 2026.
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