ICD-10 Z15.81
Billable / SpecificGenetic susceptibility to multiple endocrine neoplasia [MEN]
About ICD-10-CM Z15.81
ICD-10-CM code Z15.81 represents Genetic susceptibility to multiple endocrine neoplasia [MEN]. This is a billable/specific code in the Factors Influencing Health Status chapter (block Z15). The 2026 edition of ICD-10-CM Z15.81 became effective on October 1, 2025.
Type 1 Excludes
Pure excludes, these codes can never be coded together with Z15.81. The conditions are mutually exclusive (e.g., congenital vs acquired forms).
- multiple endocrine neoplasia [MEN] syndromes (E31.2-)
Medicare LCD Coverage for Z15.81
Local Coverage Determinations (LCDs) from CMS MACs that list Z15.81 as a covered diagnosis.
This doesn't mean the code isn't covered, it means no MAC has issued a Local Coverage Determination naming this specific code. Coverage may still apply under National Coverage Determinations or general medical-necessity rules.
Commercial Payer Coverage
Coverage policies from major commercial payers referencing Z15.81.
1 Aetna
CPT Codes Commonly Billed with Z15.81
Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.
We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.
Convert Z15.81 to ICD-9-CM
Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.
| ICD-10 | ICD-9 | Mapping Flags |
|---|---|---|
| Z15.81 | V8481 | 00000 |
Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).
Codes Adjacent To Z15.81
Other codes in section Z14-Z15 (Genetic carrier and genetic susceptibility to disease).
ICD-10 Z15.81, Billing FAQ
Is ICD-10 code Z15.81 billable? +
Yes, Z15.81 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.
What codes are Type 1 Excludes for Z15.81? +
Type 1 Excludes (never code together with Z15.81): multiple endocrine neoplasia [MEN] syndromes (E31.2-)
What ICD-9 codes does Z15.81 map to? +
Per CMS GEMs, Z15.81 maps to ICD-9 codes: V8481. Useful for legacy data review and historical claim analysis.
Get the full PayerReady toolkit
Free access to CPT/ICD-10 lookup, denial appeals, fee comparator, and claim auditing with credentialing enrollment.
Start free →Run this code through our claim audit tool
Check NCCI bundling, MUE limits, and modifier logic before submission.
Try the auditor →Did this page help?
Quick signal so we know what to improve.
If you want a code reference page that doesn't exist yet, email coding@payerready.com.
Tell us what's missing or wrong: coding@payerready.com. We respond within 5 business days.
Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on May 31, 2026.
Powered by 11K CPT · 98K ICD-10 · 860K MPFS rates · 4.5M NCCI edits · 9.5M NPIs. Our data methodology · About our coding team