ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 Z15.060

Billable / Specific

Genetic susceptibility to colorectal cancer

Z15
Block
0
Synonyms
62
LCDs
3
Payer Policies
3
Linked CPTs

About ICD-10-CM Z15.060

ICD-10-CM code Z15.060 represents Genetic susceptibility to colorectal cancer. This is a billable/specific code in the Factors Influencing Health Status chapter (block Z15). The 2026 edition of ICD-10-CM Z15.060 became effective on October 1, 2025.

Medicare LCD Coverage for Z15.060

Local Coverage Determinations (LCDs) from CMS MACs that list Z15.060 as a covered diagnosis.

62 LCDs

Showing top 10 of 62 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Colonoscopy/Sigmoidoscopy/Proctosigmoidoscopy
Article ID: 56632, Effective: 2025-10-01 00:00:00, 558 covered, 0 non-covered
CPT 45341 →
CMS LCD: Billing and Coding: Colonoscopy/Sigmoidoscopy/Proctosigmoidoscopy
Article ID: 56632, Effective: 2025-10-01 00:00:00, 558 covered, 0 non-covered
CPT 45331 →
CMS LCD: Billing and Coding: Colonoscopy/Sigmoidoscopy/Proctosigmoidoscopy
Article ID: 56632, Effective: 2025-10-01 00:00:00, 558 covered, 0 non-covered
CPT 45398 →
CMS LCD: Billing and Coding: Colonoscopy/Sigmoidoscopy/Proctosigmoidoscopy
Article ID: 56632, Effective: 2025-10-01 00:00:00, 558 covered, 0 non-covered
CPT G9999 →
CMS LCD: Billing and Coding: Colonoscopy/Sigmoidoscopy/Proctosigmoidoscopy
Article ID: 56632, Effective: 2025-10-01 00:00:00, 558 covered, 0 non-covered
CPT 44392 →
CMS LCD: Billing and Coding: Colonoscopy/Sigmoidoscopy/Proctosigmoidoscopy
Article ID: 56632, Effective: 2025-10-01 00:00:00, 558 covered, 0 non-covered
CPT 45386 →
CMS LCD: Billing and Coding: Colonoscopy/Sigmoidoscopy/Proctosigmoidoscopy
Article ID: 56632, Effective: 2025-10-01 00:00:00, 558 covered, 0 non-covered
CPT 45378 →
CMS LCD: Billing and Coding: Colonoscopy/Sigmoidoscopy/Proctosigmoidoscopy
Article ID: 56632, Effective: 2025-10-01 00:00:00, 558 covered, 0 non-covered
CPT 45305 →
CMS LCD: Billing and Coding: Colonoscopy/Sigmoidoscopy/Proctosigmoidoscopy
Article ID: 56632, Effective: 2025-10-01 00:00:00, 558 covered, 0 non-covered
CPT 45309 →
CMS LCD: Billing and Coding: Colonoscopy/Sigmoidoscopy/Proctosigmoidoscopy
Article ID: 56632, Effective: 2025-10-01 00:00:00, 558 covered, 0 non-covered
CPT 44390 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing Z15.060.

3 policies

3 Medicare

Billing and Coding: Screening Colonoscopy Converted to a Diagnostic and/or Therapeutic Colonoscopy
Policy ID: ART-55069
Billing and Coding: Incomplete Colonoscopy/Failed Colonoscopy
Policy ID: ART-55227
Billing and Coding: Colonoscopy/Sigmoidoscopy/Proctosigmoidoscopy
Policy ID: ART-56632

CPT Codes Commonly Billed with Z15.060

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

3 linkages
  • G0105 CMS LCD: Billing and Coding: Screening Colonoscopy Converted to a Diagnostic and/or Therapeutic Colonoscopy CMS LCD
  • G2204 CMS LCD: Billing and Coding: Screening Colonoscopy Converted to a Diagnostic and/or Therapeutic Colonoscopy CMS LCD
  • G0121 CMS LCD: Billing and Coding: Incomplete Colonoscopy/Failed Colonoscopy CMS LCD

ICD-10 Z15.060, Billing FAQ

Is ICD-10 code Z15.060 billable? +

Yes, Z15.060 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What CPT codes are commonly billed with Z15.060? +

Procedures frequently paired with Z15.060 include: G0105, G2204, G0121.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on May 31, 2026.

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