ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 M31.10

Billable / Specific HCC v28: 40 MCC

Thrombotic microangiopathy, unspecified

M31
Block
0
Synonyms
50
LCDs
10
Payer Policies
0
Linked CPTs

About ICD-10-CM M31.10

ICD-10-CM code M31.10 represents Thrombotic microangiopathy, unspecified. This is a billable/specific code in the Musculoskeletal and Connective Tissue chapter (block M31). The 2026 edition of ICD-10-CM M31.10 became effective on October 1, 2025.

Coding Tips for M31.10

Specialist guidance from the PayerReady Medical Coding Team. Specificity warnings, HCC capture rules, sequencing notes.

HCC capture: document with MEAT each year

M31.10 is a CMS-HCC v28 risk-adjustment code (category 40). To count for the patient Risk Adjustment Factor (RAF), document the diagnosis with MEAT language each calendar year: Monitored, Evaluated, Assessed, Treated. A diagnosis on the problem list alone does not satisfy CMS RADV audit standards. Include the diagnosis in the assessment with current status and current treatment plan.

Inpatient DRG impact: MCC

M31.10 is designated MCC for MS-DRG grouping. On inpatient claims, this code can shift the DRG to the with-MCC variant when documented as a present-on-admission secondary diagnosis. Hospital CDI programs flag MCC opportunities during chart review. Failure to capture this code may leave 30 to 80 percent of the inpatient stay revenue unrealized.

Medicare Advantage HCC Impact

CMS-HCC v28 (current)
Category 40
ESRD-HCC
Category 40
RxHCC (Part D)
Category 40

Capture this diagnosis annually for accurate risk adjustment. Missed HCC captures are the #1 revenue leak in Medicare Advantage risk programs.

Inpatient DRG Impact, MCC

codes Thrombotic microangiopathy, unspecified. As a Major Complication/Comorbidity (MCC), this can shift the DRG assignment to a higher-weighted category, substantial reimbursement impact.

Medicare LCD Coverage for M31.10

Local Coverage Determinations (LCDs) from CMS MACs that list M31.10 as a covered diagnosis.

50 LCDs

Showing top 10 of 50 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Non-Invasive Arterial Duplex Ultrasound of the Upper and Lower Extremities
Article ID: 60318, Effective: , 409 covered, 1 non-covered
CPT 93926 →
CMS LCD: Billing and Coding: Non-Invasive Arterial Duplex Ultrasound of the Upper and Lower Extremities
Article ID: 60318, Effective: , 409 covered, 1 non-covered
CPT 93930 →
CMS LCD: Billing and Coding: Non-Invasive Arterial Duplex Ultrasound of the Upper and Lower Extremities
Article ID: 60318, Effective: , 409 covered, 1 non-covered
CPT 93925 →
CMS LCD: Billing and Coding: Non-Invasive Arterial Duplex Ultrasound of the Upper and Lower Extremities
Article ID: 60318, Effective: , 409 covered, 1 non-covered
CPT 93931 →
CMS LCD: Billing and Coding: Non-Invasive Arterial Duplex Ultrasound of the Upper and Lower Extremities
Article ID: 60314, Effective: , 409 covered, 1 non-covered
CPT 93926 →
CMS LCD: Billing and Coding: Non-Invasive Arterial Duplex Ultrasound of the Upper and Lower Extremities
Article ID: 60314, Effective: , 409 covered, 1 non-covered
CPT 93930 →
CMS LCD: Billing and Coding: Non-Invasive Arterial Duplex Ultrasound of the Upper and Lower Extremities
Article ID: 60314, Effective: , 409 covered, 1 non-covered
CPT 93925 →
CMS LCD: Billing and Coding: Non-Invasive Arterial Duplex Ultrasound of the Upper and Lower Extremities
Article ID: 60314, Effective: , 409 covered, 1 non-covered
CPT 93931 →
CMS LCD: Billing and Coding: Immune Globulin Intravenous (IVIg)
Article ID: 57187, Effective: 2026-04-01 00:00:00, 102 covered, 0 non-covered
CPT J1561 →
CMS LCD: Billing and Coding: Immune Globulin Intravenous (IVIg)
Article ID: 57187, Effective: 2026-04-01 00:00:00, 102 covered, 0 non-covered
CPT J1556 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing M31.10.

10 policies

5 Medicare

Billing and Coding: Immune Globulin Intravenous (IVIg)
Policy ID: ART-57187
Billing and Coding: Non-Invasive Cerebrovascular Studies
Policy ID: ART-57592
Billing and Coding: Non-Invasive Peripheral Arterial Vascular Studies
Policy ID: ART-57593
Billing and Coding: Off-label Use of Rituximab and Rituximab Biosimilars
Policy ID: ART-59101
Billing and Coding: Off-label Use of Rituximab and Rituximab Biosimilars
Policy ID: ART-60186

1 Aetna

ADAMTS13 Assay for Thrombotic Thrombocytopenic Purpura (TTP)
Policy ID: CPB-0780

CPT Codes Commonly Billed with M31.10

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

No procedure linkages on file for M31.10

We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.

ICD-10 M31.10, Billing FAQ

Is ICD-10 code M31.10 billable? +

Yes, M31.10 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

Does M31.10 affect Medicare Advantage HCC risk adjustment? +

Yes. M31.10 maps to CMS-HCC v28 category 40. Capture this diagnosis annually for accurate Medicare Advantage risk score.

Is M31.10 a CC or MCC for inpatient DRG? +

Yes, this code is designated as MCC. Documenting as a secondary diagnosis on inpatient claims can shift the DRG to a higher-weighted category.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on May 31, 2026.

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