ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 E43

Billable / Specific HCC v28: 21 MCC

Unspecified severe protein-calorie malnutrition

E43
Block
1
Synonyms
152
LCDs
11
Payer Policies
0
Linked CPTs

About ICD-10-CM E43

ICD-10-CM code E43 represents Unspecified severe protein-calorie malnutrition. This is a billable/specific code in the Endocrine, Nutritional, and Metabolic chapter (block E43). The 2026 edition of ICD-10-CM E43 became effective on October 1, 2025.

Coding Tips for E43

Specialist guidance from the PayerReady Medical Coding Team. Specificity warnings, HCC capture rules, sequencing notes.

HCC capture: document with MEAT each year

E43 is a CMS-HCC v28 risk-adjustment code (category 21). To count for the patient Risk Adjustment Factor (RAF), document the diagnosis with MEAT language each calendar year: Monitored, Evaluated, Assessed, Treated. A diagnosis on the problem list alone does not satisfy CMS RADV audit standards. Include the diagnosis in the assessment with current status and current treatment plan.

Inpatient DRG impact: MCC

E43 is designated MCC for MS-DRG grouping. On inpatient claims, this code can shift the DRG to the with-MCC variant when documented as a present-on-admission secondary diagnosis. Hospital CDI programs flag MCC opportunities during chart review. Failure to capture this code may leave 30 to 80 percent of the inpatient stay revenue unrealized.

Inclusion Terms / Approximate Synonyms

Clinical terms and conditions classified under E43. Per CMS ICD-10-CM Tabular 2026.

  • Starvation edema

Medicare Advantage HCC Impact

CMS-HCC v28 (current)
Category 21
ESRD-HCC
Category 21
RxHCC (Part D)
Category 21

Capture this diagnosis annually for accurate risk adjustment. Missed HCC captures are the #1 revenue leak in Medicare Advantage risk programs.

Inpatient DRG Impact, MCC

codes Unspecified severe protein-calorie malnutrition. As a Major Complication/Comorbidity (MCC), this can shift the DRG assignment to a higher-weighted category, substantial reimbursement impact.

Medicare LCD Coverage for E43

Local Coverage Determinations (LCDs) from CMS MACs that list E43 as a covered diagnosis.

152 LCDs

Showing top 10 of 152 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Magnesium
Article ID: 59186, Effective: 2025-10-01 00:00:00, 4358 covered, 0 non-covered
CPT 83735 →
CMS LCD: Billing and Coding: Vitamin D Assay Testing
Article ID: 57736, Effective: 2024-10-01 00:00:00, 553 covered, 0 non-covered
CPT 82652 →
CMS LCD: Billing and Coding: Vitamin D Assay Testing
Article ID: 57736, Effective: 2024-10-01 00:00:00, 553 covered, 0 non-covered
CPT 82306 →
CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function
Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered
CPT 82306 →
CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function
Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered
CPT 82607 →
CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function
Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered
CPT 82746 →
CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function
Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered
CPT 85385 →
CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function
Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered
CPT 83090 →
CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function
Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered
CPT 82652 →
CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function
Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered
CPT 84207 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing E43.

11 policies

2 Aetna

Back Pain - Invasive Procedures - Medical Clinical Policy Bulletins | Aetna
Policy ID: CPB-0016
Nutritional Support - Medical Clinical Policy Bulletins | Aetna
Policy ID: CPB-0061

1 Cigna

Serum Folate and Red Blood Cell Folate Testing - (0567)
Policy ID: MM_0567

5 Medicare

Billing and Coding: Upper Gastrointestinal Endoscopy and Visualization
Policy ID: ART-56389
Billing and Coding: Assays for Vitamins and Metabolic Function
Policy ID: ART-56416
Billing and Coding: Vitamin D Assay Testing
Policy ID: ART-56798
Billing and Coding: Upper Gastrointestinal Endoscopy (Diagnostic and Therapeutic)
Policy ID: ART-57414
Billing and Coding: Vitamin D Assay Testing
Policy ID: ART-57718

CPT Codes Commonly Billed with E43

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

No procedure linkages on file for E43

We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.

Convert E43 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
E43 262 10000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 E43, Billing FAQ

Is ICD-10 code E43 billable? +

Yes, E43 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What other names or terms map to E43? +

ICD-10 E43 includes: Starvation edema.

Does E43 affect Medicare Advantage HCC risk adjustment? +

Yes. E43 maps to CMS-HCC v28 category 21. Capture this diagnosis annually for accurate Medicare Advantage risk score.

Is E43 a CC or MCC for inpatient DRG? +

Yes, this code is designated as MCC. Documenting as a secondary diagnosis on inpatient claims can shift the DRG to a higher-weighted category.

What ICD-9 codes does E43 map to? +

Per CMS GEMs, E43 maps to ICD-9 codes: 262. Useful for legacy data review and historical claim analysis.

Get the full PayerReady toolkit

Free access to CPT/ICD-10 lookup, denial appeals, fee comparator, and claim auditing with credentialing enrollment.

Start free →

Run this code through our claim audit tool

Check NCCI bundling, MUE limits, and modifier logic before submission.

Try the auditor →

Did this page help?

Quick signal so we know what to improve.

Thanks!

If you want a code reference page that doesn't exist yet, email coding@payerready.com.

Sorry to hear that.

Tell us what's missing or wrong: coding@payerready.com. We respond within 5 business days.

Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on May 31, 2026.

Powered by 11K CPT · 98K ICD-10 · 860K MPFS rates · 4.5M NCCI edits · 9.5M NPIs. Our data methodology · About our coding team

Faster Approvals

Ready to Cut Your Enrollment Timeline in Half?

Join providers in all 50 states who handed off credentialing to a dedicated specialist. Create your free account in minutes and start enrolling the same day.

All 50 States Covered
No Long-Term Contracts
HIPAA HIPAA Compliant Platform
Dedicated Specialist Included