ICD-10 E10.21
Billable / SpecificType 1 diabetes mellitus with diabetic nephropathy
About ICD-10-CM E10.21
ICD-10-CM code E10.21 represents Type 1 diabetes mellitus with diabetic nephropathy. This is a billable/specific code in the Endocrine, Nutritional, and Metabolic chapter (block E10). The 2026 edition of ICD-10-CM E10.21 became effective on October 1, 2025.
Inclusion Terms / Approximate Synonyms
Clinical terms and conditions classified under E10.21. Per CMS ICD-10-CM Tabular 2026.
- Type 1 diabetes mellitus with intercapillary glomerulosclerosis
- Type 1 diabetes mellitus with intracapillary glomerulonephrosis
- Type 1 diabetes mellitus with Kimmelstiel-Wilson disease
Medicare Advantage HCC Impact
Capture this diagnosis annually for accurate risk adjustment. Missed HCC captures are the #1 revenue leak in Medicare Advantage risk programs.
Medicare LCD Coverage for E10.21
Local Coverage Determinations (LCDs) from CMS MACs that list E10.21 as a covered diagnosis.
Showing top 10 of 210 total . Click a CPT for full coverage scope.
Commercial Payer Coverage
Coverage policies from major commercial payers referencing E10.21.
1 Cigna
5 Medicare
CPT Codes Commonly Billed with E10.21
Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.
- 51741 CMS LCD: Billing and Coding: Urodynamics CMS LCD
- 51728 CMS LCD: Billing and Coding: Urodynamics CMS LCD
- 51729 CMS LCD: Billing and Coding: Urodynamics CMS LCD
- 55899 CMS LCD: Billing and Coding: Urodynamics CMS LCD
- 51792 CMS LCD: Billing and Coding: Urodynamics CMS LCD
- 51736 CMS LCD: Billing and Coding: Urodynamics CMS LCD
- 51726 CMS LCD: Billing and Coding: Urodynamics CMS LCD
- 51727 CMS LCD: Billing and Coding: Urodynamics CMS LCD
- 51797 CMS LCD: Billing and Coding: Urodynamics CMS LCD
- 01782 CMS LCD: Billing and Coding: Monitored Anesthesia Care CMS LCD
Convert E10.21 to ICD-9-CM
Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.
| ICD-10 | ICD-9 | Mapping Flags |
|---|---|---|
| E10.21 | 25041 | 10000 |
Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).
Codes Adjacent To E10.21
Other codes in section E08-E13 (Diabetes mellitus).
ICD-10 E10.21, Billing FAQ
Is ICD-10 code E10.21 billable? +
Yes, E10.21 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.
What other names or terms map to E10.21? +
ICD-10 E10.21 includes: Type 1 diabetes mellitus with intercapillary glomerulosclerosis; Type 1 diabetes mellitus with intracapillary glomerulonephrosis; Type 1 diabetes mellitus with Kimmelstiel-Wilson disease.
What CPT codes are commonly billed with E10.21? +
Procedures frequently paired with E10.21 include: 51741, 51728, 51729, 55899, 51792.
What ICD-9 codes does E10.21 map to? +
Per CMS GEMs, E10.21 maps to ICD-9 codes: 25041. Useful for legacy data review and historical claim analysis.
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on May 31, 2026.
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