ICD-10 E08.21
Billable / SpecificDiabetes mellitus due to underlying condition with diabetic nephropathy
About ICD-10-CM E08.21
ICD-10-CM code E08.21 represents Diabetes mellitus due to underlying condition with diabetic nephropathy. This is a billable/specific code in the Endocrine, Nutritional, and Metabolic chapter (block E08). The 2026 edition of ICD-10-CM E08.21 became effective on October 1, 2025.
Inclusion Terms / Approximate Synonyms
Clinical terms and conditions classified under E08.21. Per CMS ICD-10-CM Tabular 2026.
- Diabetes mellitus due to underlying condition with intercapillary glomerulosclerosis
- Diabetes mellitus due to underlying condition with intracapillary glomerulonephrosis
- Diabetes mellitus due to underlying condition with Kimmelstiel-Wilson disease
Medicare Advantage HCC Impact
Capture this diagnosis annually for accurate risk adjustment. Missed HCC captures are the #1 revenue leak in Medicare Advantage risk programs.
Medicare LCD Coverage for E08.21
Local Coverage Determinations (LCDs) from CMS MACs that list E08.21 as a covered diagnosis.
Showing top 10 of 86 total . Click a CPT for full coverage scope.
Commercial Payer Coverage
Coverage policies from major commercial payers referencing E08.21.
1 Cigna
5 Medicare
CPT Codes Commonly Billed with E08.21
Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.
- 95923 CMS LCD: Billing and Coding: Autonomic Function Testing CMS LCD
- 95924 CMS LCD: Billing and Coding: Autonomic Function Testing CMS LCD
- 95921 CMS LCD: Billing and Coding: Autonomic Function Testing CMS LCD
- 95922 CMS LCD: Billing and Coding: Autonomic Function Testing CMS LCD
- 11719 CMS LCD: Billing and Coding: Routine Foot Care and Debridement of Nails CMS LCD
- G0127 CMS LCD: Billing and Coding: Routine Foot Care and Debridement of Nails CMS LCD
- 11056 CMS LCD: Billing and Coding: Routine Foot Care and Debridement of Nails CMS LCD
- 0448T CMS LCD: Billing and Coding: Implantable Continuous Glucose Monitors (I-CGM) CMS LCD
- 0446T CMS LCD: Billing and Coding: Implantable Continuous Glucose Monitors (I-CGM) CMS LCD
- 0447T CMS LCD: Billing and Coding: Implantable Continuous Glucose Monitors (I-CGM) CMS LCD
Convert E08.21 to ICD-9-CM
Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.
| ICD-10 | ICD-9 | Mapping Flags |
|---|---|---|
| E08.21 | 24940 | 10111 |
| E08.21 | 58181 | 10112 |
Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).
Codes Adjacent To E08.21
Other codes in section E08-E13 (Diabetes mellitus).
ICD-10 E08.21, Billing FAQ
Is ICD-10 code E08.21 billable? +
Yes, E08.21 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.
What other names or terms map to E08.21? +
ICD-10 E08.21 includes: Diabetes mellitus due to underlying condition with intercapillary glomerulosclerosis; Diabetes mellitus due to underlying condition with intracapillary glomerulonephrosis; Diabetes mellitus due to underlying condition with Kimmelstiel-Wilson disease.
What CPT codes are commonly billed with E08.21? +
Procedures frequently paired with E08.21 include: 95923, 95924, 95921, 95922, 11719.
What ICD-9 codes does E08.21 map to? +
Per CMS GEMs, E08.21 maps to ICD-9 codes: 24940, 58181. Useful for legacy data review and historical claim analysis.
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on May 31, 2026.
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