ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 D53.0

Billable / Specific

Protein deficiency anemia

D53
Block
2
Synonyms
13
LCDs
3
Payer Policies
0
Linked CPTs

About ICD-10-CM D53.0

ICD-10-CM code D53.0 represents Protein deficiency anemia. This is a billable/specific code in the Blood and Blood-forming Organs chapter (block D53). The 2026 edition of ICD-10-CM D53.0 became effective on October 1, 2025.

Inclusion Terms / Approximate Synonyms

Clinical terms and conditions classified under D53.0. Per CMS ICD-10-CM Tabular 2026.

  • Amino-acid deficiency anemia
  • Orotaciduric anemia

Type 1 Excludes

Pure excludes, these codes can never be coded together with D53.0. The conditions are mutually exclusive (e.g., congenital vs acquired forms).

  • Lesch-Nyhan syndrome (E79.1)

Medicare LCD Coverage for D53.0

Local Coverage Determinations (LCDs) from CMS MACs that list D53.0 as a covered diagnosis.

13 LCDs

Showing top 10 of 13 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Flow Cytometry
Article ID: 56464, Effective: 2026-03-05 00:00:00, 1361 covered, 0 non-covered
CPT 88189 →
CMS LCD: Billing and Coding: Flow Cytometry
Article ID: 56464, Effective: 2026-03-05 00:00:00, 1361 covered, 0 non-covered
CPT 86360 →
CMS LCD: Billing and Coding: Flow Cytometry
Article ID: 56464, Effective: 2026-03-05 00:00:00, 1361 covered, 0 non-covered
CPT 86361 →
CMS LCD: Billing and Coding: Flow Cytometry
Article ID: 56464, Effective: 2026-03-05 00:00:00, 1361 covered, 0 non-covered
CPT 88187 →
CMS LCD: Billing and Coding: Flow Cytometry
Article ID: 56464, Effective: 2026-03-05 00:00:00, 1361 covered, 0 non-covered
CPT 86359 →
CMS LCD: Billing and Coding: Flow Cytometry
Article ID: 56464, Effective: 2026-03-05 00:00:00, 1361 covered, 0 non-covered
CPT 86356 →
CMS LCD: Billing and Coding: Flow Cytometry
Article ID: 56464, Effective: 2026-03-05 00:00:00, 1361 covered, 0 non-covered
CPT 88188 →
CMS LCD: Billing and Coding: Flow Cytometry
Article ID: 56464, Effective: 2026-03-05 00:00:00, 1361 covered, 0 non-covered
CPT 88184 →
CMS LCD: Billing and Coding: Flow Cytometry
Article ID: 56464, Effective: 2026-03-05 00:00:00, 1361 covered, 0 non-covered
CPT 88185 →
CMS LCD: Billing and Coding: Flow Cytometry
Article ID: 56464, Effective: 2026-03-05 00:00:00, 1361 covered, 0 non-covered
CPT 86367 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing D53.0.

3 policies

2 Cigna

Flow Cytometry - (0538)
Policy ID: MM_0538
Serum Folate and Red Blood Cell Folate Testing - (0567)
Policy ID: MM_0567

1 Medicare

Billing and Coding: Flow Cytometry
Policy ID: ART-56464

CPT Codes Commonly Billed with D53.0

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

No procedure linkages on file for D53.0

We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.

Convert D53.0 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
D53.0 2814 00000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 D53.0, Billing FAQ

Is ICD-10 code D53.0 billable? +

Yes, D53.0 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What other names or terms map to D53.0? +

ICD-10 D53.0 includes: Amino-acid deficiency anemia; Orotaciduric anemia.

What codes are Type 1 Excludes for D53.0? +

Type 1 Excludes (never code together with D53.0): Lesch-Nyhan syndrome (E79.1)

What ICD-9 codes does D53.0 map to? +

Per CMS GEMs, D53.0 maps to ICD-9 codes: 2814. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on May 31, 2026.

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