ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 D51.0

Billable / Specific

Vitamin B12 deficiency anemia due to intrinsic factor deficiency

D51
Block
4
Synonyms
285
LCDs
21
Payer Policies
5
Linked CPTs

About ICD-10-CM D51.0

ICD-10-CM code D51.0 represents Vitamin B12 deficiency anemia due to intrinsic factor deficiency. This is a billable/specific code in the Blood and Blood-forming Organs chapter (block D51). The 2026 edition of ICD-10-CM D51.0 became effective on October 1, 2025.

Inclusion Terms / Approximate Synonyms

Clinical terms and conditions classified under D51.0. Per CMS ICD-10-CM Tabular 2026.

  • Addison anemia
  • Biermer anemia
  • Pernicious (congenital) anemia
  • Congenital intrinsic factor deficiency

Medicare LCD Coverage for D51.0

Local Coverage Determinations (LCDs) from CMS MACs that list D51.0 as a covered diagnosis.

285 LCDs

Showing top 10 of 285 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Homocysteine Level, Serum
Article ID: 56675, Effective: 2024-10-01 00:00:00, 550 covered, 0 non-covered
CPT 83090 →
CMS LCD: Billing and Coding: MolDX: Blood Product Molecular Antigen Typing
Article ID: 57155, Effective: 2024-10-01 00:00:00, 115 covered, 0 non-covered
CPT 0198U →
CMS LCD: Billing and Coding: MolDX: Blood Product Molecular Antigen Typing
Article ID: 57155, Effective: 2024-10-01 00:00:00, 115 covered, 0 non-covered
CPT 81109 →
CMS LCD: Billing and Coding: MolDX: Blood Product Molecular Antigen Typing
Article ID: 57155, Effective: 2024-10-01 00:00:00, 115 covered, 0 non-covered
CPT 0197U →
CMS LCD: Billing and Coding: MolDX: Blood Product Molecular Antigen Typing
Article ID: 57155, Effective: 2024-10-01 00:00:00, 115 covered, 0 non-covered
CPT 0183U →
CMS LCD: Billing and Coding: MolDX: Blood Product Molecular Antigen Typing
Article ID: 57155, Effective: 2024-10-01 00:00:00, 115 covered, 0 non-covered
CPT 81107 →
CMS LCD: Billing and Coding: MolDX: Blood Product Molecular Antigen Typing
Article ID: 57155, Effective: 2024-10-01 00:00:00, 115 covered, 0 non-covered
CPT 0186U →
CMS LCD: Billing and Coding: MolDX: Blood Product Molecular Antigen Typing
Article ID: 57155, Effective: 2024-10-01 00:00:00, 115 covered, 0 non-covered
CPT 81106 →
CMS LCD: Billing and Coding: MolDX: Blood Product Molecular Antigen Typing
Article ID: 57155, Effective: 2024-10-01 00:00:00, 115 covered, 0 non-covered
CPT 0184U →
CMS LCD: Billing and Coding: MolDX: Blood Product Molecular Antigen Typing
Article ID: 57155, Effective: 2024-10-01 00:00:00, 115 covered, 0 non-covered
CPT 0221U →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing D51.0.

21 policies

2 Cigna

Flow Cytometry - (0538)
Policy ID: MM_0538
Serum Folate and Red Blood Cell Folate Testing - (0567)
Policy ID: MM_0567

5 Medicare

Billing and Coding: Routine Foot Care
Policy ID: ART-52996
Billing and Coding: Foot Care
Policy ID: ART-56232
Billing and Coding: Upper Gastrointestinal Endoscopy and Visualization
Policy ID: ART-56389
Billing and Coding: Assays for Vitamins and Metabolic Function
Policy ID: ART-56416
Billing and Coding: Flow Cytometry
Policy ID: ART-56464

2 Aetna

Vitamin B-12 Therapy
Policy ID: CPB-0536
Upper Gastrointestinal Endoscopy and Gastrointestinal Biopsy
Policy ID: CPB-0738

CPT Codes Commonly Billed with D51.0

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

5 linkages
  • 11719 CMS LCD: Billing and Coding: Routine Foot Care and Debridement of Nails CMS LCD
  • G0127 CMS LCD: Billing and Coding: Routine Foot Care and Debridement of Nails CMS LCD
  • 11056 CMS LCD: Billing and Coding: Routine Foot Care and Debridement of Nails CMS LCD
  • J3420 CMS LCD: Billing and Coding: Vitamin B<sub>12</sub> Injections CMS LCD
  • J3425 CMS LCD: Billing and Coding: Vitamin B<sub>12</sub> Injections CMS LCD

Convert D51.0 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
D51.0 2810 10000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 D51.0, Billing FAQ

Is ICD-10 code D51.0 billable? +

Yes, D51.0 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What other names or terms map to D51.0? +

ICD-10 D51.0 includes: Addison anemia; Biermer anemia; Pernicious (congenital) anemia, and 1 more clinical synonyms.

What CPT codes are commonly billed with D51.0? +

Procedures frequently paired with D51.0 include: 11719, G0127, 11056, J3420, J3425.

What ICD-9 codes does D51.0 map to? +

Per CMS GEMs, D51.0 maps to ICD-9 codes: 2810. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on May 31, 2026.

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