ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 D21.3

Billable / Specific

Benign neoplasm of connective and other soft tissue of thorax

D21
Block
3
Synonyms
139
LCDs
6
Payer Policies
0
Linked CPTs

About ICD-10-CM D21.3

ICD-10-CM code D21.3 represents Benign neoplasm of connective and other soft tissue of thorax. This is a billable/specific code in the Neoplasms chapter (block D21). The 2026 edition of ICD-10-CM D21.3 became effective on October 1, 2025.

Inclusion Terms / Approximate Synonyms

Clinical terms and conditions classified under D21.3. Per CMS ICD-10-CM Tabular 2026.

  • Benign neoplasm of axilla
  • Benign neoplasm of diaphragm
  • Benign neoplasm of great vessels

Type 1 Excludes

Pure excludes, these codes can never be coded together with D21.3. The conditions are mutually exclusive (e.g., congenital vs acquired forms).

  • benign neoplasm of heart (D15.1)
  • benign neoplasm of mediastinum (D15.2)
  • benign neoplasm of thymus (D15.0)

Medicare LCD Coverage for D21.3

Local Coverage Determinations (LCDs) from CMS MACs that list D21.3 as a covered diagnosis.

139 LCDs

Showing top 10 of 139 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64420 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 20561 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64415 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64447 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64448 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64416 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64405 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64454 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64425 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64450 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing D21.3.

6 policies

5 Medicare

Billing and Coding: Removal of Benign and Malignant Skin Lesions
Policy ID: ART-56346
Billing and Coding: Computerized Axial Tomography (CT), Thorax
Policy ID: ART-56580
Billing and Coding: Implantable Infusion Pump
Policy ID: ART-56695
Billing and Coding: Peripheral Nerve Blocks
Policy ID: ART-57452
Billing and Coding: Peripheral Nerve Blocks
Policy ID: ART-57788

1 Aetna

Magnetic Resonance Imaging of the Cardiovascular System - Cardiac MRI
Policy ID: CPB-0520

CPT Codes Commonly Billed with D21.3

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

No procedure linkages on file for D21.3

We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.

Convert D21.3 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
D21.3 2154 00000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 D21.3, Billing FAQ

Is ICD-10 code D21.3 billable? +

Yes, D21.3 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What other names or terms map to D21.3? +

ICD-10 D21.3 includes: Benign neoplasm of axilla; Benign neoplasm of diaphragm; Benign neoplasm of great vessels.

What codes are Type 1 Excludes for D21.3? +

Type 1 Excludes (never code together with D21.3): benign neoplasm of heart (D15.1); benign neoplasm of mediastinum (D15.2); benign neoplasm of thymus (D15.0)

What ICD-9 codes does D21.3 map to? +

Per CMS GEMs, D21.3 maps to ICD-9 codes: 2154. Useful for legacy data review and historical claim analysis.

Get the full PayerReady toolkit

Free access to CPT/ICD-10 lookup, denial appeals, fee comparator, and claim auditing with credentialing enrollment.

Start free →

Run this code through our claim audit tool

Check NCCI bundling, MUE limits, and modifier logic before submission.

Try the auditor →

Did this page help?

Quick signal so we know what to improve.

Thanks!

If you want a code reference page that doesn't exist yet, email coding@payerready.com.

Sorry to hear that.

Tell us what's missing or wrong: coding@payerready.com. We respond within 5 business days.

Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on May 31, 2026.

Powered by 11K CPT · 98K ICD-10 · 860K MPFS rates · 4.5M NCCI edits · 9.5M NPIs. Our data methodology · About our coding team

Faster Approvals

Ready to Cut Your Enrollment Timeline in Half?

Join providers in all 50 states who handed off credentialing to a dedicated specialist. Create your free account in minutes and start enrolling the same day.

All 50 States Covered
No Long-Term Contracts
HIPAA HIPAA Compliant Platform
Dedicated Specialist Included