ICD-10 D21
Non-Billable HeaderOther benign neoplasms of connective and other soft tissue
About ICD-10-CM D21
ICD-10-CM code D21 represents Other benign neoplasms of connective and other soft tissue. This is a non-billable header code in the Neoplasms chapter (block D21). The 2026 edition of ICD-10-CM D21 became effective on October 1, 2025. Non-billable codes cannot be used as a primary or secondary diagnosis on a claim, use a more specific child code instead.
Type 1 Excludes
Pure excludes, these codes can never be coded together with D21. The conditions are mutually exclusive (e.g., congenital vs acquired forms).
- benign neoplasm of articular cartilage (D16.-)
- benign neoplasm of cartilage of larynx (D14.1)
- benign neoplasm of cartilage of nose (D14.0)
- benign neoplasm of connective tissue of breast (D24.-)
- benign neoplasm of peripheral nerves and autonomic nervous system (D36.1-)
- benign neoplasm of peritoneum (D20.1)
- benign neoplasm of retroperitoneum (D20.0)
- benign neoplasm of uterine ligament, any (D28.2)
- benign neoplasm of vascular tissue (D18.-)
- hemangioma (D18.0-)
- lipomatous neoplasm (D17.-)
- lymphangioma (D18.1)
- uterine leiomyoma (D25.-)
Includes
- benign neoplasm of blood vessel
- benign neoplasm of bursa
- benign neoplasm of cartilage
- benign neoplasm of fascia
- benign neoplasm of fat
- benign neoplasm of ligament, except uterine
- benign neoplasm of lymphatic channel
- benign neoplasm of muscle
- benign neoplasm of synovia
- benign neoplasm of tendon (sheath)
- benign stromal tumors
Medicare LCD Coverage for D21
Local Coverage Determinations (LCDs) from CMS MACs that list D21 as a covered diagnosis.
This doesn't mean the code isn't covered, it means no MAC has issued a Local Coverage Determination naming this specific code. Coverage may still apply under National Coverage Determinations or general medical-necessity rules.
Commercial Payer Coverage
Coverage policies from major commercial payers referencing D21.
Our payer policy database covers Aetna, Cigna, Anthem, BCBS, Humana, and Medicare Advantage plans, but D21 doesn't currently appear in any indexed policy. The code may still be covered under standard plan benefits.
CPT Codes Commonly Billed with D21
Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.
We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.
Codes Adjacent To D21
Other codes in section D10-D36 (Benign neoplasms, except benign neuroendocrine tumors).
ICD-10 D21, Billing FAQ
Is ICD-10 code D21 billable? +
No, D21 is a non-billable header code. Use a more specific child code from block D21 when submitting claims.
What codes are Type 1 Excludes for D21? +
Type 1 Excludes (never code together with D21): benign neoplasm of articular cartilage (D16.-); benign neoplasm of cartilage of larynx (D14.1); benign neoplasm of cartilage of nose (D14.0)
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on June 1, 2026.
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