ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 C49.4

Billable / Specific HCC v28: 10 CC

Malignant neoplasm of connective and soft tissue of abdomen

C49
Block
2
Synonyms
856
LCDs
49
Payer Policies
6
Linked CPTs

About ICD-10-CM C49.4

ICD-10-CM code C49.4 represents Malignant neoplasm of connective and soft tissue of abdomen. This is a billable/specific code in the Neoplasms chapter (block C49). The 2026 edition of ICD-10-CM C49.4 became effective on October 1, 2025.

Coding Tips for C49.4

Specialist guidance from the PayerReady Medical Coding Team. Specificity warnings, HCC capture rules, sequencing notes.

HCC capture: document with MEAT each year

C49.4 is a CMS-HCC v28 risk-adjustment code (category 10). To count for the patient Risk Adjustment Factor (RAF), document the diagnosis with MEAT language each calendar year: Monitored, Evaluated, Assessed, Treated. A diagnosis on the problem list alone does not satisfy CMS RADV audit standards. Include the diagnosis in the assessment with current status and current treatment plan.

Inpatient DRG impact: CC

C49.4 is designated CC for MS-DRG grouping. On inpatient claims, this code can shift the DRG to the with-CC variant when documented as a present-on-admission secondary diagnosis. Hospital CDI programs flag CC opportunities during chart review. Failure to capture this code may leave 30 to 80 percent of the inpatient stay revenue unrealized.

Inclusion Terms / Approximate Synonyms

Clinical terms and conditions classified under C49.4. Per CMS ICD-10-CM Tabular 2026.

  • Malignant neoplasm of abdominal wall
  • Malignant neoplasm of hypochondrium

Medicare Advantage HCC Impact

CMS-HCC v28 (current)
Category 10
ESRD-HCC
Category 10
RxHCC (Part D)
Category 10

Capture this diagnosis annually for accurate risk adjustment. Missed HCC captures are the #1 revenue leak in Medicare Advantage risk programs.

Inpatient DRG Impact, CC

codes Malignant neoplasm of connective and soft tissue of abdomen. As a Complication/Comorbidity (CC), this contributes to DRG severity adjustment when documented alongside the principal diagnosis.

Medicare LCD Coverage for C49.4

Local Coverage Determinations (LCDs) from CMS MACs that list C49.4 as a covered diagnosis.

856 LCDs

Showing top 10 of 856 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74170 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74177 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74160 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74178 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74150 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 72194 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74176 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 72192 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 72193 →
CMS LCD: Billing and Coding: MolDX: Non-Next Generation Sequencing Targeted Molecular Panel Tests for Predictive Testing in Cancer
Article ID: 60240, Effective: , 680 covered, 0 non-covered
CPT 81479 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing C49.4.

49 policies

5 Medicare

Billing and Coding: Bevacizumab and biosimilars
Policy ID: ART-52370
Billing and Coding: Paclitaxel (e.g., Taxol�/Abraxane �)
Policy ID: ART-52450
Oral Anticancer Drugs - Policy Article
Policy ID: ART-52479
Oral Antiemetic Drugs (Replacement for Intravenous Antiemetics) - Policy Article
Policy ID: ART-52480
Billing and Coding: Cardiac Blood Pool Imaging (Multiple Gated Acquisition Scanning- MUGA, Ventriculography) When Performed in Conjunction with Cardiotoxic Chemotherapy
Policy ID: ART-54768

CPT Codes Commonly Billed with C49.4

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

6 linkages
  • C9726 CMS LCD: Billing and Coding: Intraoperative Radiation Therapy CMS LCD
  • 19294 CMS LCD: Billing and Coding: Intraoperative Radiation Therapy CMS LCD
  • 76145 CMS LCD: Billing and Coding: Intraoperative Radiation Therapy CMS LCD
  • 77469 CMS LCD: Billing and Coding: Intraoperative Radiation Therapy CMS LCD
  • 77425 CMS LCD: Billing and Coding: Intraoperative Radiation Therapy CMS LCD
  • 77424 CMS LCD: Billing and Coding: Intraoperative Radiation Therapy CMS LCD

Convert C49.4 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
C49.4 1715 10000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 C49.4, Billing FAQ

Is ICD-10 code C49.4 billable? +

Yes, C49.4 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What other names or terms map to C49.4? +

ICD-10 C49.4 includes: Malignant neoplasm of abdominal wall; Malignant neoplasm of hypochondrium.

Does C49.4 affect Medicare Advantage HCC risk adjustment? +

Yes. C49.4 maps to CMS-HCC v28 category 10. Capture this diagnosis annually for accurate Medicare Advantage risk score.

Is C49.4 a CC or MCC for inpatient DRG? +

Yes, this code is designated as CC. Documenting as a secondary diagnosis on inpatient claims can shift the DRG to a higher-weighted category.

What CPT codes are commonly billed with C49.4? +

Procedures frequently paired with C49.4 include: C9726, 19294, 76145, 77469, 77425.

What ICD-9 codes does C49.4 map to? +

Per CMS GEMs, C49.4 maps to ICD-9 codes: 1715. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on May 31, 2026.

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