ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 R53.81

Billable / Specific

Other malaise

R53
Block
5
Synonyms
164
LCDs
17
Payer Policies
0
Linked CPTs

About ICD-10-CM R53.81

ICD-10-CM code R53.81 represents Other malaise. This is a billable/specific code in the Symptoms, Signs, and Abnormal Findings chapter (block R53). The 2026 edition of ICD-10-CM R53.81 became effective on October 1, 2025.

Inclusion Terms / Approximate Synonyms

Clinical terms and conditions classified under R53.81. Per CMS ICD-10-CM Tabular 2026.

  • Chronic debility
  • Debility NOS
  • General physical deterioration
  • Malaise NOS
  • Nervous debility

Type 1 Excludes

Pure excludes, these codes can never be coded together with R53.81. The conditions are mutually exclusive (e.g., congenital vs acquired forms).

  • age-related physical debility (R54)

Medicare LCD Coverage for R53.81

Local Coverage Determinations (LCDs) from CMS MACs that list R53.81 as a covered diagnosis.

164 LCDs

Showing top 10 of 164 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Nerve Conduction Studies and Electromyography
Article ID: 57668, Effective: 2025-10-01 00:00:00, 1629 covered, 0 non-covered
CPT 95909 →
CMS LCD: Billing and Coding: Nerve Conduction Studies and Electromyography
Article ID: 57668, Effective: 2025-10-01 00:00:00, 1629 covered, 0 non-covered
CPT 95887 →
CMS LCD: Billing and Coding: Nerve Conduction Studies and Electromyography
Article ID: 57668, Effective: 2025-10-01 00:00:00, 1629 covered, 0 non-covered
CPT 95912 →
CMS LCD: Billing and Coding: Nerve Conduction Studies and Electromyography
Article ID: 57668, Effective: 2025-10-01 00:00:00, 1629 covered, 0 non-covered
CPT 95999 →
CMS LCD: Billing and Coding: Nerve Conduction Studies and Electromyography
Article ID: 57668, Effective: 2025-10-01 00:00:00, 1629 covered, 0 non-covered
CPT 95910 →
CMS LCD: Billing and Coding: Nerve Conduction Studies and Electromyography
Article ID: 57668, Effective: 2025-10-01 00:00:00, 1629 covered, 0 non-covered
CPT 95870 →
CMS LCD: Billing and Coding: Nerve Conduction Studies and Electromyography
Article ID: 57668, Effective: 2025-10-01 00:00:00, 1629 covered, 0 non-covered
CPT 95860 →
CMS LCD: Billing and Coding: Nerve Conduction Studies and Electromyography
Article ID: 57668, Effective: 2025-10-01 00:00:00, 1629 covered, 0 non-covered
CPT 95913 →
CMS LCD: Billing and Coding: Nerve Conduction Studies and Electromyography
Article ID: 57668, Effective: 2025-10-01 00:00:00, 1629 covered, 0 non-covered
CPT 95869 →
CMS LCD: Billing and Coding: Nerve Conduction Studies and Electromyography
Article ID: 57668, Effective: 2025-10-01 00:00:00, 1629 covered, 0 non-covered
CPT G0255 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing R53.81.

17 policies

4 Aetna

Obstructive Sleep Apnea in Adults - Medical Clinical Policy Bulletins | Aetna
Policy ID: CPB-0004
Multiple Sleep Latency Test (MSLT) and Maintenance of Wakefulness Test (MWT)
Policy ID: CPB-0330
Chronic Fatigue Syndrome
Policy ID: CPB-0369
Influenza Rapid Diagnostic Tests
Policy ID: CPB-0476

3 Cigna

Nucleic Acid Pathogen Testing - (0530)
Policy ID: MM_0530
Transvaginal Ultrasound, Non-Obstetrical - (0398)
Policy ID: MM_0398
Vitamin D Testing - (0526) ---- future effective policy
Policy ID: MM_0526

5 Medicare

Billing and Coding: Nerve Conduction Studies and Electromyography
Policy ID: ART-54969
Billing and Coding: Nerve Conduction Studies and Electromyography
Policy ID: ART-56619
Billing and Coding: Parathormone (Parathyroid Hormone)
Policy ID: ART-57122
Billing and Coding: Serum Magnesium
Policy ID: ART-57189
Billing and Coding: Oximetry Services
Policy ID: ART-57205

CPT Codes Commonly Billed with R53.81

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

No procedure linkages on file for R53.81

We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.

Convert R53.81 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
R53.81 78079 10000
R53.81 7993 10000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 R53.81, Billing FAQ

Is ICD-10 code R53.81 billable? +

Yes, R53.81 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What other names or terms map to R53.81? +

ICD-10 R53.81 includes: Chronic debility; Debility NOS; General physical deterioration, and 2 more clinical synonyms.

What codes are Type 1 Excludes for R53.81? +

Type 1 Excludes (never code together with R53.81): age-related physical debility (R54)

What ICD-9 codes does R53.81 map to? +

Per CMS GEMs, R53.81 maps to ICD-9 codes: 78079, 7993. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on June 1, 2026.

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