ICD-10 E53.1
Billable / SpecificPyridoxine deficiency
About ICD-10-CM E53.1
ICD-10-CM code E53.1 represents Pyridoxine deficiency. This is a billable/specific code in the Endocrine, Nutritional, and Metabolic chapter (block E53). The 2026 edition of ICD-10-CM E53.1 became effective on October 1, 2025.
Inclusion Terms / Approximate Synonyms
Clinical terms and conditions classified under E53.1. Per CMS ICD-10-CM Tabular 2026.
- Vitamin B6 deficiency
Type 1 Excludes
Pure excludes, these codes can never be coded together with E53.1. The conditions are mutually exclusive (e.g., congenital vs acquired forms).
- pyridoxine-responsive sideroblastic anemia (D64.3)
Medicare LCD Coverage for E53.1
Local Coverage Determinations (LCDs) from CMS MACs that list E53.1 as a covered diagnosis.
Showing top 10 of 111 total . Click a CPT for full coverage scope.
Commercial Payer Coverage
Coverage policies from major commercial payers referencing E53.1.
5 Medicare
CPT Codes Commonly Billed with E53.1
Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.
We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.
Convert E53.1 to ICD-9-CM
Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.
| ICD-10 | ICD-9 | Mapping Flags |
|---|---|---|
| E53.1 | 2661 | 00000 |
Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).
Codes Adjacent To E53.1
Other codes in section E50-E64 (Other nutritional deficiencies).
ICD-10 E53.1, Billing FAQ
Is ICD-10 code E53.1 billable? +
Yes, E53.1 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.
What other names or terms map to E53.1? +
ICD-10 E53.1 includes: Vitamin B6 deficiency.
What codes are Type 1 Excludes for E53.1? +
Type 1 Excludes (never code together with E53.1): pyridoxine-responsive sideroblastic anemia (D64.3)
What ICD-9 codes does E53.1 map to? +
Per CMS GEMs, E53.1 maps to ICD-9 codes: 2661. Useful for legacy data review and historical claim analysis.
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on May 31, 2026.
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