ICD-10 D75.81
Billable / Specific HCC v28: 46 CCMyelofibrosis
About ICD-10-CM D75.81
ICD-10-CM code D75.81 represents Myelofibrosis. This is a billable/specific code in the Blood and Blood-forming Organs chapter (block D75). The 2026 edition of ICD-10-CM D75.81 became effective on October 1, 2025.
Coding Tips for D75.81
Specialist guidance from the PayerReady Medical Coding Team. Specificity warnings, HCC capture rules, sequencing notes.
D75.81 is a CMS-HCC v28 risk-adjustment code (category 46). To count for the patient Risk Adjustment Factor (RAF), document the diagnosis with MEAT language each calendar year: Monitored, Evaluated, Assessed, Treated. A diagnosis on the problem list alone does not satisfy CMS RADV audit standards. Include the diagnosis in the assessment with current status and current treatment plan.
D75.81 is designated CC for MS-DRG grouping. On inpatient claims, this code can shift the DRG to the with-CC variant when documented as a present-on-admission secondary diagnosis. Hospital CDI programs flag CC opportunities during chart review. Failure to capture this code may leave 30 to 80 percent of the inpatient stay revenue unrealized.
Inclusion Terms / Approximate Synonyms
Clinical terms and conditions classified under D75.81. Per CMS ICD-10-CM Tabular 2026.
- Myelofibrosis NOS
- Secondary myelofibrosis NOS
Type 1 Excludes
Pure excludes, these codes can never be coded together with D75.81. The conditions are mutually exclusive (e.g., congenital vs acquired forms).
- acute myelofibrosis (C94.4-)
- idiopathic myelofibrosis (D47.1)
- leukoerythroblastic anemia (D61.82)
- myelofibrosis with myeloid metaplasia (D47.4)
- myelophthisic anemia (D61.82)
- myelophthisis (D61.82)
- primary myelofibrosis (D47.1)
Use Additional Code
When coding D75.81, also report these additional codes when applicable.
- code, if applicable, for associated therapy-related myelodysplastic syndrome (D46.-)
Coding Notes
Code First
- the underlying disorder, such as:
- malignant neoplasm of breast (C50.-)
Medicare Advantage HCC Impact
Capture this diagnosis annually for accurate risk adjustment. Missed HCC captures are the #1 revenue leak in Medicare Advantage risk programs.
Inpatient DRG Impact, CC
codes Myelofibrosis. As a Complication/Comorbidity (CC), this contributes to DRG severity adjustment when documented alongside the principal diagnosis.
Medicare LCD Coverage for D75.81
Local Coverage Determinations (LCDs) from CMS MACs that list D75.81 as a covered diagnosis.
Showing top 10 of 1,221 total . Click a CPT for full coverage scope.
Commercial Payer Coverage
Coverage policies from major commercial payers referencing D75.81.
5 Medicare
CPT Codes Commonly Billed with D75.81
Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.
- 0027U CMS LCD: Billing and Coding: MolDX: Non-Next Generation Sequencing Tests for the Diagnosis of BCR-ABL Negative Myeloproliferative Neoplasms CMS LCD
- 81270 CMS LCD: Billing and Coding: MolDX: Non-Next Generation Sequencing Tests for the Diagnosis of BCR-ABL Negative Myeloproliferative Neoplasms CMS LCD
- 81338 CMS LCD: Billing and Coding: MolDX: Non-Next Generation Sequencing Tests for the Diagnosis of BCR-ABL Negative Myeloproliferative Neoplasms CMS LCD
- 81339 CMS LCD: Billing and Coding: MolDX: Non-Next Generation Sequencing Tests for the Diagnosis of BCR-ABL Negative Myeloproliferative Neoplasms CMS LCD
- 81219 CMS LCD: Billing and Coding: MolDX: Non-Next Generation Sequencing Tests for the Diagnosis of BCR-ABL Negative Myeloproliferative Neoplasms CMS LCD
- 81279 CMS LCD: Billing and Coding: MolDX: Non-Next Generation Sequencing Tests for the Diagnosis of BCR-ABL Negative Myeloproliferative Neoplasms CMS LCD
- 93990 CMS LCD: Billing and Coding: Non-Invasive Peripheral Venous Vascular and Hemodialysis Access Studies CMS LCD
- 93985 CMS LCD: Billing and Coding: Non-Invasive Peripheral Venous Vascular and Hemodialysis Access Studies CMS LCD
- 93986 CMS LCD: Billing and Coding: Non-Invasive Peripheral Venous Vascular and Hemodialysis Access Studies CMS LCD
Convert D75.81 to ICD-9-CM
Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.
| ICD-10 | ICD-9 | Mapping Flags |
|---|---|---|
| D75.81 | 28983 | 00000 |
Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).
Codes Adjacent To D75.81
Other codes in section D70-D77 (Other disorders of blood and blood-forming organs).
ICD-10 D75.81, Billing FAQ
Is ICD-10 code D75.81 billable? +
Yes, D75.81 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.
What other names or terms map to D75.81? +
ICD-10 D75.81 includes: Myelofibrosis NOS; Secondary myelofibrosis NOS.
What codes are Type 1 Excludes for D75.81? +
Type 1 Excludes (never code together with D75.81): acute myelofibrosis (C94.4-); idiopathic myelofibrosis (D47.1); leukoerythroblastic anemia (D61.82)
Does D75.81 affect Medicare Advantage HCC risk adjustment? +
Yes. D75.81 maps to CMS-HCC v28 category 46. Capture this diagnosis annually for accurate Medicare Advantage risk score.
Is D75.81 a CC or MCC for inpatient DRG? +
Yes, this code is designated as CC. Documenting as a secondary diagnosis on inpatient claims can shift the DRG to a higher-weighted category.
What CPT codes are commonly billed with D75.81? +
Procedures frequently paired with D75.81 include: 0027U, 81270, 81338, 81339, 81219.
What ICD-9 codes does D75.81 map to? +
Per CMS GEMs, D75.81 maps to ICD-9 codes: 28983. Useful for legacy data review and historical claim analysis.
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on May 31, 2026.
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