ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 D72.0

Billable / Specific HCC v28: 47

Genetic anomalies of leukocytes

D72
Block
9
Synonyms
41
LCDs
4
Payer Policies
0
Linked CPTs

About ICD-10-CM D72.0

ICD-10-CM code D72.0 represents Genetic anomalies of leukocytes. This is a billable/specific code in the Blood and Blood-forming Organs chapter (block D72). The 2026 edition of ICD-10-CM D72.0 became effective on October 1, 2025.

Coding Tips for D72.0

Specialist guidance from the PayerReady Medical Coding Team. Specificity warnings, HCC capture rules, sequencing notes.

HCC capture: document with MEAT each year

D72.0 is a CMS-HCC v28 risk-adjustment code (category 47). To count for the patient Risk Adjustment Factor (RAF), document the diagnosis with MEAT language each calendar year: Monitored, Evaluated, Assessed, Treated. A diagnosis on the problem list alone does not satisfy CMS RADV audit standards. Include the diagnosis in the assessment with current status and current treatment plan.

Inclusion Terms / Approximate Synonyms

Clinical terms and conditions classified under D72.0. Per CMS ICD-10-CM Tabular 2026.

  • Alder (granulation) (granulocyte) anomaly
  • Alder syndrome
  • Hereditary leukocytic hypersegmentation
  • Hereditary leukocytic hyposegmentation
  • Hereditary leukomelanopathy
  • May-Hegglin (granulation) (granulocyte) anomaly
  • May-Hegglin syndrome
  • Pelger-Huët (granulation) (granulocyte) anomaly
  • Pelger-Huët syndrome

Type 1 Excludes

Pure excludes, these codes can never be coded together with D72.0. The conditions are mutually exclusive (e.g., congenital vs acquired forms).

  • Chédiak (-Steinbrinck)-Higashi syndrome (E70.330)

Medicare Advantage HCC Impact

CMS-HCC v28 (current)
Category 47
ESRD-HCC
Category 47
RxHCC (Part D)
Category 47

Capture this diagnosis annually for accurate risk adjustment. Missed HCC captures are the #1 revenue leak in Medicare Advantage risk programs.

Medicare LCD Coverage for D72.0

Local Coverage Determinations (LCDs) from CMS MACs that list D72.0 as a covered diagnosis.

41 LCDs

Showing top 10 of 41 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Lab: Flow Cytometry
Article ID: 57689, Effective: 2025-11-06 00:00:00, 1518 covered, 0 non-covered
CPT 88189 →
CMS LCD: Billing and Coding: Lab: Flow Cytometry
Article ID: 57689, Effective: 2025-11-06 00:00:00, 1518 covered, 0 non-covered
CPT 86360 →
CMS LCD: Billing and Coding: Lab: Flow Cytometry
Article ID: 57689, Effective: 2025-11-06 00:00:00, 1518 covered, 0 non-covered
CPT 86361 →
CMS LCD: Billing and Coding: Lab: Flow Cytometry
Article ID: 57689, Effective: 2025-11-06 00:00:00, 1518 covered, 0 non-covered
CPT 88187 →
CMS LCD: Billing and Coding: Lab: Flow Cytometry
Article ID: 57689, Effective: 2025-11-06 00:00:00, 1518 covered, 0 non-covered
CPT 86363 →
CMS LCD: Billing and Coding: Lab: Flow Cytometry
Article ID: 57689, Effective: 2025-11-06 00:00:00, 1518 covered, 0 non-covered
CPT 86359 →
CMS LCD: Billing and Coding: Lab: Flow Cytometry
Article ID: 57689, Effective: 2025-11-06 00:00:00, 1518 covered, 0 non-covered
CPT 86356 →
CMS LCD: Billing and Coding: Lab: Flow Cytometry
Article ID: 57689, Effective: 2025-11-06 00:00:00, 1518 covered, 0 non-covered
CPT 88188 →
CMS LCD: Billing and Coding: Lab: Flow Cytometry
Article ID: 57689, Effective: 2025-11-06 00:00:00, 1518 covered, 0 non-covered
CPT 88184 →
CMS LCD: Billing and Coding: Lab: Flow Cytometry
Article ID: 57689, Effective: 2025-11-06 00:00:00, 1518 covered, 0 non-covered
CPT 88185 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing D72.0.

4 policies

1 Cigna

Flow Cytometry - (0538)
Policy ID: MM_0538

3 Medicare

Billing and Coding: Lab: Flow Cytometry
Policy ID: ART-55717
Billing and Coding: Flow Cytometry
Policy ID: ART-56464
Billing and Coding: Lab: Flow Cytometry
Policy ID: ART-57689

CPT Codes Commonly Billed with D72.0

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

No procedure linkages on file for D72.0

We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.

Convert D72.0 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
D72.0 2882 00000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 D72.0, Billing FAQ

Is ICD-10 code D72.0 billable? +

Yes, D72.0 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What other names or terms map to D72.0? +

ICD-10 D72.0 includes: Alder (granulation) (granulocyte) anomaly; Alder syndrome; Hereditary leukocytic hypersegmentation, and 6 more clinical synonyms.

What codes are Type 1 Excludes for D72.0? +

Type 1 Excludes (never code together with D72.0): Chédiak (-Steinbrinck)-Higashi syndrome (E70.330)

Does D72.0 affect Medicare Advantage HCC risk adjustment? +

Yes. D72.0 maps to CMS-HCC v28 category 47. Capture this diagnosis annually for accurate Medicare Advantage risk score.

What ICD-9 codes does D72.0 map to? +

Per CMS GEMs, D72.0 maps to ICD-9 codes: 2882. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on June 1, 2026.

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