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ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 D68.4

Billable / Specific HCC v28: 48 CC

Acquired coagulation factor deficiency

D68
Block
2
Synonyms
38
LCDs
7
Payer Policies
3
Linked CPTs

About ICD-10-CM D68.4

ICD-10-CM code D68.4 represents Acquired coagulation factor deficiency. This is a billable/specific code in the Blood and Blood-forming Organs chapter (block D68). The 2026 edition of ICD-10-CM D68.4 became effective on October 1, 2025.

Coding Tips for D68.4

Specialist guidance from the PayerReady Medical Coding Team. Specificity warnings, HCC capture rules, sequencing notes.

HCC capture: document with MEAT each year

D68.4 is a CMS-HCC v28 risk-adjustment code (category 48). To count for the patient Risk Adjustment Factor (RAF), document the diagnosis with MEAT language each calendar year: Monitored, Evaluated, Assessed, Treated. A diagnosis on the problem list alone does not satisfy CMS RADV audit standards. Include the diagnosis in the assessment with current status and current treatment plan.

Inpatient DRG impact: CC

D68.4 is designated CC for MS-DRG grouping. On inpatient claims, this code can shift the DRG to the with-CC variant when documented as a present-on-admission secondary diagnosis. Hospital CDI programs flag CC opportunities during chart review. Failure to capture this code may leave 30 to 80 percent of the inpatient stay revenue unrealized.

Inclusion Terms / Approximate Synonyms

Clinical terms and conditions classified under D68.4. Per CMS ICD-10-CM Tabular 2026.

  • Deficiency of coagulation factor due to liver disease
  • Deficiency of coagulation factor due to vitamin K deficiency

Type 1 Excludes

Pure excludes, these codes can never be coded together with D68.4. The conditions are mutually exclusive (e.g., congenital vs acquired forms).

  • vitamin K deficiency of newborn (P53)

Medicare Advantage HCC Impact

CMS-HCC v28 (current)
Category 48
ESRD-HCC
Category 48
RxHCC (Part D)
Category 48

Capture this diagnosis annually for accurate risk adjustment. Missed HCC captures are the #1 revenue leak in Medicare Advantage risk programs.

Inpatient DRG Impact, CC

codes Acquired coagulation factor deficiency. As a Complication/Comorbidity (CC), this contributes to DRG severity adjustment when documented alongside the principal diagnosis.

Medicare LCD Coverage for D68.4

Local Coverage Determinations (LCDs) from CMS MACs that list D68.4 as a covered diagnosis.

38 LCDs

Showing top 10 of 38 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function
Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered
CPT 82306 →
CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function
Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered
CPT 82607 →
CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function
Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered
CPT 82746 →
CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function
Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered
CPT 85385 →
CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function
Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered
CPT 83090 →
CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function
Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered
CPT 82652 →
CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function
Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered
CPT 84207 →
CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function
Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered
CPT 86352 →
CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function
Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered
CPT 82379 →
CMS LCD: Billing and Coding: Assays for Vitamins and Metabolic Function
Article ID: 56416, Effective: 2025-10-01 00:00:00, 899 covered, 1 non-covered
CPT 83698 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing D68.4.

7 policies

5 Medicare

Billing and Coding: Chemotherapy Agents for Non-Oncologic Conditions
Policy ID: ART-55639
Billing and Coding: Rituximab
Policy ID: ART-56380
Billing and Coding: Assays for Vitamins and Metabolic Function
Policy ID: ART-56416
Billing and Coding: Routine Foot Care
Policy ID: ART-57954
Billing and Coding: Off-label Use of Rituximab and Rituximab Biosimilars
Policy ID: ART-59101

1 Aetna

Human Fibrinogen Concentrate (RiaSTAP and Fibryga)
Policy ID: CPB-0792

CPT Codes Commonly Billed with D68.4

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

3 linkages
  • J9190 CMS LCD: Billing and Coding: Chemotherapy Agents for Non-Oncologic Conditions CMS LCD
  • J9260 CMS LCD: Billing and Coding: Chemotherapy Agents for Non-Oncologic Conditions CMS LCD
  • J9215 CMS LCD: Billing and Coding: Chemotherapy Agents for Non-Oncologic Conditions CMS LCD

Convert D68.4 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
D68.4 2867 10000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 D68.4, Billing FAQ

Is ICD-10 code D68.4 billable? +

Yes, D68.4 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What other names or terms map to D68.4? +

ICD-10 D68.4 includes: Deficiency of coagulation factor due to liver disease; Deficiency of coagulation factor due to vitamin K deficiency.

What codes are Type 1 Excludes for D68.4? +

Type 1 Excludes (never code together with D68.4): vitamin K deficiency of newborn (P53)

Does D68.4 affect Medicare Advantage HCC risk adjustment? +

Yes. D68.4 maps to CMS-HCC v28 category 48. Capture this diagnosis annually for accurate Medicare Advantage risk score.

Is D68.4 a CC or MCC for inpatient DRG? +

Yes, this code is designated as CC. Documenting as a secondary diagnosis on inpatient claims can shift the DRG to a higher-weighted category.

What CPT codes are commonly billed with D68.4? +

Procedures frequently paired with D68.4 include: J9190, J9260, J9215.

What ICD-9 codes does D68.4 map to? +

Per CMS GEMs, D68.4 maps to ICD-9 codes: 2867. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on July 16, 2026.

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