ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 D46.A

Billable / Specific HCC v28: 46

Refractory cytopenia with multilineage dysplasia

D46
Block
0
Synonyms
1,207
LCDs
36
Payer Policies
19
Linked CPTs

About ICD-10-CM D46.A

ICD-10-CM code D46.A represents Refractory cytopenia with multilineage dysplasia. This is a billable/specific code in the Neoplasms chapter (block D46). The 2026 edition of ICD-10-CM D46.A became effective on October 1, 2025.

Coding Tips for D46.A

Specialist guidance from the PayerReady Medical Coding Team. Specificity warnings, HCC capture rules, sequencing notes.

HCC capture: document with MEAT each year

D46.A is a CMS-HCC v28 risk-adjustment code (category 46). To count for the patient Risk Adjustment Factor (RAF), document the diagnosis with MEAT language each calendar year: Monitored, Evaluated, Assessed, Treated. A diagnosis on the problem list alone does not satisfy CMS RADV audit standards. Include the diagnosis in the assessment with current status and current treatment plan.

Medicare Advantage HCC Impact

CMS-HCC v28 (current)
Category 46
ESRD-HCC
Category 46
RxHCC (Part D)
Category 46

Capture this diagnosis annually for accurate risk adjustment. Missed HCC captures are the #1 revenue leak in Medicare Advantage risk programs.

Medicare LCD Coverage for D46.A

Local Coverage Determinations (LCDs) from CMS MACs that list D46.A as a covered diagnosis.

1,207 LCDs

Showing top 10 of 1,207 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: MDS FISH
Article ID: 57661, Effective: 2025-10-23 00:00:00, 10 covered, 0 non-covered
CPT 88291 →
CMS LCD: Billing and Coding: MDS FISH
Article ID: 57661, Effective: 2025-10-23 00:00:00, 10 covered, 0 non-covered
CPT 88271 →
CMS LCD: Billing and Coding: MDS FISH
Article ID: 57661, Effective: 2025-10-23 00:00:00, 10 covered, 0 non-covered
CPT 88273 →
CMS LCD: Billing and Coding: MDS FISH
Article ID: 57661, Effective: 2025-10-23 00:00:00, 10 covered, 0 non-covered
CPT 88275 →
CMS LCD: Billing and Coding: MDS FISH
Article ID: 57661, Effective: 2025-10-23 00:00:00, 10 covered, 0 non-covered
CPT 88274 →
CMS LCD: Billing and Coding: MolDX: Lab-Developed Tests for Inherited Cancer Syndromes in Patients with Cancer
Article ID: 58679, Effective: 2026-02-05 00:00:00, 1346 covered, 0 non-covered
CPT 81215 →
CMS LCD: Billing and Coding: MolDX: Lab-Developed Tests for Inherited Cancer Syndromes in Patients with Cancer
Article ID: 58679, Effective: 2026-02-05 00:00:00, 1346 covered, 0 non-covered
CPT 81300 →
CMS LCD: Billing and Coding: MolDX: Lab-Developed Tests for Inherited Cancer Syndromes in Patients with Cancer
Article ID: 58679, Effective: 2026-02-05 00:00:00, 1346 covered, 0 non-covered
CPT 81351 →
CMS LCD: Billing and Coding: MolDX: Lab-Developed Tests for Inherited Cancer Syndromes in Patients with Cancer
Article ID: 58679, Effective: 2026-02-05 00:00:00, 1346 covered, 0 non-covered
CPT 81167 →
CMS LCD: Billing and Coding: MolDX: Lab-Developed Tests for Inherited Cancer Syndromes in Patients with Cancer
Article ID: 58679, Effective: 2026-02-05 00:00:00, 1346 covered, 0 non-covered
CPT 81405 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing D46.A.

36 policies

1 Cigna

Serum Folate and Red Blood Cell Folate Testing - (0567)
Policy ID: MM_0567

5 Medicare

Oral Anticancer Drugs - Policy Article
Policy ID: ART-52479
Oral Antiemetic Drugs (Replacement for Intravenous Antiemetics) - Policy Article
Policy ID: ART-52480
Billing and Coding: Biomarkers for Oncology
Policy ID: ART-52986
Billing and Coding: Lab: Flow Cytometry
Policy ID: ART-55717
Billing and Coding: Molecular Pathology Procedures
Policy ID: ART-56199

CPT Codes Commonly Billed with D46.A

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

19 linkages
  • 88291 CMS LCD: Billing and Coding: MDS FISH CMS LCD
  • 88275 CMS LCD: Billing and Coding: MDS FISH CMS LCD
  • 88273 CMS LCD: Billing and Coding: MDS FISH CMS LCD
  • 88274 CMS LCD: Billing and Coding: MDS FISH CMS LCD
  • 88271 CMS LCD: Billing and Coding: MDS FISH CMS LCD
  • 83018 CMS LCD: Billing and Coding: Heavy Metal Testing CMS LCD
  • 82175 CMS LCD: Billing and Coding: Heavy Metal Testing CMS LCD
  • 82108 CMS LCD: Billing and Coding: Heavy Metal Testing CMS LCD
  • 84630 CMS LCD: Billing and Coding: Heavy Metal Testing CMS LCD
  • 83015 CMS LCD: Billing and Coding: Heavy Metal Testing CMS LCD

Convert D46.A to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
D46.A 23872 10000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 D46.A, Billing FAQ

Is ICD-10 code D46.A billable? +

Yes, D46.A is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

Does D46.A affect Medicare Advantage HCC risk adjustment? +

Yes. D46.A maps to CMS-HCC v28 category 46. Capture this diagnosis annually for accurate Medicare Advantage risk score.

What CPT codes are commonly billed with D46.A? +

Procedures frequently paired with D46.A include: 88291, 88275, 88273, 88274, 88271.

What ICD-9 codes does D46.A map to? +

Per CMS GEMs, D46.A maps to ICD-9 codes: 23872. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on May 31, 2026.

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