ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 D22.121

Billable / Specific

Melanocytic nevi of left upper eyelid, including canthus

D22
Block
0
Synonyms
383
LCDs
18
Payer Policies
46
Linked CPTs

About ICD-10-CM D22.121

ICD-10-CM code D22.121 represents Melanocytic nevi of left upper eyelid, including canthus. This is a billable/specific code in the Neoplasms chapter (block D22). The 2026 edition of ICD-10-CM D22.121 became effective on October 1, 2025.

Medicare LCD Coverage for D22.121

Local Coverage Determinations (LCDs) from CMS MACs that list D22.121 as a covered diagnosis.

383 LCDs

Showing top 10 of 383 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: MolDX: Molecular Assays for the Diagnosis of Cutaneous Melanoma
Article ID: 59163, Effective: 2026-01-22 00:00:00, 18 covered, 0 non-covered
CPT 0090U →
CMS LCD: Billing and Coding: MolDX: Molecular Assays for the Diagnosis of Cutaneous Melanoma
Article ID: 59163, Effective: 2026-01-22 00:00:00, 18 covered, 0 non-covered
CPT 81479 →
CMS LCD: Billing and Coding: MolDX: Molecular Assays for the Diagnosis of Cutaneous Melanoma
Article ID: 59163, Effective: 2026-01-22 00:00:00, 18 covered, 0 non-covered
CPT 0314U →
CMS LCD: Billing and Coding: Removal of Benign Skin Lesions
Article ID: 57482, Effective: 2026-01-01 00:00:00, 138 covered, 1 non-covered
CPT 11313 →
CMS LCD: Billing and Coding: Removal of Benign Skin Lesions
Article ID: 57482, Effective: 2026-01-01 00:00:00, 138 covered, 1 non-covered
CPT 11300 →
CMS LCD: Billing and Coding: Removal of Benign Skin Lesions
Article ID: 57482, Effective: 2026-01-01 00:00:00, 138 covered, 1 non-covered
CPT 11306 →
CMS LCD: Billing and Coding: Removal of Benign Skin Lesions
Article ID: 57482, Effective: 2026-01-01 00:00:00, 138 covered, 1 non-covered
CPT 11423 →
CMS LCD: Billing and Coding: Removal of Benign Skin Lesions
Article ID: 57482, Effective: 2026-01-01 00:00:00, 138 covered, 1 non-covered
CPT 11442 →
CMS LCD: Billing and Coding: Removal of Benign Skin Lesions
Article ID: 57482, Effective: 2026-01-01 00:00:00, 138 covered, 1 non-covered
CPT 11307 →
CMS LCD: Billing and Coding: Removal of Benign Skin Lesions
Article ID: 57482, Effective: 2026-01-01 00:00:00, 138 covered, 1 non-covered
CPT 11303 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing D22.121.

18 policies

5 Medicare

Billing and Coding: Removal of Benign and Malignant Skin Lesions
Policy ID: ART-56346
Billing and Coding: Blepharoplasty
Policy ID: ART-56439
Billing and Coding: Flow Cytometry
Policy ID: ART-56464
Billing and Coding: Blepharoplasty, Eyelid Surgery, and Brow Lift
Policy ID: ART-56503
Billing and Coding: Mohs Micrographic Surgery (MMS)
Policy ID: ART-56732

CPT Codes Commonly Billed with D22.121

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

46 linkages
  • 0314U CMS LCD: Billing and Coding: MolDX: Molecular Assays for the Diagnosis of Cutaneous Melanoma CMS LCD
  • 0090U CMS LCD: Billing and Coding: MolDX: Molecular Assays for the Diagnosis of Cutaneous Melanoma CMS LCD
  • 11305 CMS LCD: Billing and Coding: Removal of Benign Skin Lesions CMS LCD
  • 11404 CMS LCD: Billing and Coding: Removal of Benign Skin Lesions CMS LCD
  • 11444 CMS LCD: Billing and Coding: Removal of Benign Skin Lesions CMS LCD
  • 11403 CMS LCD: Billing and Coding: Removal of Benign Skin Lesions CMS LCD
  • 11442 CMS LCD: Billing and Coding: Removal of Benign Skin Lesions CMS LCD
  • 11307 CMS LCD: Billing and Coding: Removal of Benign Skin Lesions CMS LCD
  • 11301 CMS LCD: Billing and Coding: Removal of Benign Skin Lesions CMS LCD
  • 17108 CMS LCD: Billing and Coding: Removal of Benign Skin Lesions CMS LCD

ICD-10 D22.121, Billing FAQ

Is ICD-10 code D22.121 billable? +

Yes, D22.121 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What CPT codes are commonly billed with D22.121? +

Procedures frequently paired with D22.121 include: 0314U, 0090U, 11305, 11404, 11444.

Get the full PayerReady toolkit

Free access to CPT/ICD-10 lookup, denial appeals, fee comparator, and claim auditing with credentialing enrollment.

Start free →

Run this code through our claim audit tool

Check NCCI bundling, MUE limits, and modifier logic before submission.

Try the auditor →

Did this page help?

Quick signal so we know what to improve.

Thanks!

If you want a code reference page that doesn't exist yet, email coding@payerready.com.

Sorry to hear that.

Tell us what's missing or wrong: coding@payerready.com. We respond within 5 business days.

Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on May 31, 2026.

Powered by 11K CPT · 98K ICD-10 · 860K MPFS rates · 4.5M NCCI edits · 9.5M NPIs. Our data methodology · About our coding team

Faster Approvals

Ready to Cut Your Enrollment Timeline in Half?

Join providers in all 50 states who handed off credentialing to a dedicated specialist. Create your free account in minutes and start enrolling the same day.

All 50 States Covered
No Long-Term Contracts
HIPAA HIPAA Compliant Platform
Dedicated Specialist Included