CPT 64605
Global 010 ActiveInjection treatment of nerve
CPT 64605 Billing & Documentation Guide
CPT code 64605 (Injection treatment of nerve) is classified under Surgery (Endocrine/Nervous/Eye/Ear) with a global period indicator of 010. The 2026 Medicare Physician Fee Schedule assigns a work RVU of 5.51, a non-facility practice expense RVU of 25.12, and a malpractice RVU of 2.33, a total non-facility RVU of 32.96 and facility RVU of 12.69. With the current conversion factor of $33.4009, the national average non-facility reimbursement is approximately $1130.05, though rates vary from $944.85 to $1455.88 based on MAC locality and Geographic Practice Cost Indices (GPCIs).
When billing 64605, ensure documentation supports medical necessity and the specific components required for the code's level of service. For E/M codes, document MDM (medical decision-making) elements: problems addressed, data reviewed, and risk. For procedural codes, document the indication, technique, and any complications. Always verify NCCI edits before bundling 64605 with related codes; this code has 10 PTP bundling relationships on file (see table below).
Payment Status & Global Period
Active code (paid under MPFS)
10-day global period (minor procedure: pre-op day + procedure + 10 days post-op)
MUE Limit (Medically Unlikely Edits)
Submitting more than 1 units of 64605 for the same patient on the same date triggers automatic line denial unless an appropriate modifier and supporting documentation justify the higher quantity.
RVU Breakdown, CPT 64605
| Component | Non-Facility | Facility |
|---|---|---|
| Work RVU | 5.51 | 5.51 |
| Practice Expense RVU | 25.12 | 4.85 |
| Malpractice RVU | 2.33 | 2.33 |
| Total RVU | 32.96 | 12.69 |
| Conversion Factor | $33.4009 | |
2026 Medicare Reimbursement by State, CPT 64605
State-level averages across all MAC localities. Non-facility rates typically apply to office-based services; facility rates apply to hospital outpatient / inpatient.
| State | Non-Facility | Facility | Range (Non-Fac) | Localities |
|---|---|---|---|---|
| California | $1225.65 | $424.53 | $1148.46 - $1455.88 | 29 |
| Florida | $1177.36 | $498.07 | $1103.12 - $1254.29 | 3 |
| Georgia | $1077.87 | $431.97 | $1025.22 - $1130.51 | 2 |
| Illinois | $1144.12 | $489.93 | $1071.71 - $1207.16 | 4 |
| Michigan | $1081.43 | $445.69 | $1037.94 - $1124.91 | 2 |
| North Carolina | $1016.58 | $384.91 | $1016.58 - $1016.58 | 1 |
| New York | $1234.59 | $479.29 | $1035.83 - $1337.94 | 5 |
| Ohio | $1028.52 | $410.39 | $1028.52 - $1028.52 | 1 |
| Pennsylvania | $1090.72 | $427.56 | $1027.81 - $1153.63 | 2 |
| Texas | $1083.36 | $416.82 | $1019.86 - $1141.05 | 8 |
Source: CMS PFSRVU 2026 · Updated 2026-04-01. Full locality-level detail available for all 53 states, contact us for custom reports.
NCCI Bundling Edits, CPT 64605
Procedure-to-procedure (PTP) edits. If you bill any of these codes with 64605 on the same date of service, review the modifier indicator and payer policy before submission.
| Partner Code | Relationship | Modifier Allowed | Rationale |
|---|---|---|---|
| 0213T | Column 1 (primary), can be billed with modifier | No | Misuse of Column Two code with Column One code |
| 0216T | Column 1 (primary), can be billed with modifier | No | Misuse of Column Two code with Column One code |
| 0228T | Column 1 (primary), can be billed with modifier | No | Standards of medical/surgical practice |
| 0230T | Column 1 (primary), can be billed with modifier | No | Standards of medical/surgical practice |
| 0333T | Column 1 (primary), can be billed with modifier | No | CPT Manual or CMS manual coding instruction |
| 0464T | Column 1 (primary), can be billed with modifier | No | CPT Manual or CMS manual coding instruction |
| 0596T | Column 1 (primary), can be billed with modifier | Yes | Standards of medical/surgical practice |
| 0597T | Column 1 (primary), can be billed with modifier | Yes | Standards of medical/surgical practice |
| 0708T | Column 1 (primary), can be billed with modifier | Yes | Standards of medical/surgical practice |
| 0709T | Column 1 (primary), can be billed with modifier | Yes | Standards of medical/surgical practice |
Frequently Asked Questions, CPT 64605
What does CPT code 64605 mean? +
CPT code 64605 represents: Injection treatment of nerve. It's in the Surgery (Endocrine/Nervous/Eye/Ear) category with a global period of 010.
What is the Medicare reimbursement for CPT 64605? +
The 2026 Medicare national average non-facility payment for CPT 64605 is $1130.05. Rates range from $944.85 to $1455.88 across 53 states depending on MAC locality and GPCIs.
What modifiers can I use with CPT 64605? +
Surgery codes commonly use modifier 22 (increased procedural services), 50 (bilateral), 51 (multiple procedures), 52 (reduced services), 58/78/79 (staged, unplanned return, unrelated within global), 62 (co-surgeons), 80/82 (assistant surgeon), and 59 or the X{EPSU} subset for distinct procedural service.
What bundling edits apply to CPT 64605? +
This code has 10 NCCI PTP bundling relationships. See the NCCI Bundling section below for full list.
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on May 31, 2026.
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