CPT 64600
Global 010 ActiveInjection treatment of nerve
CPT 64600 Billing & Documentation Guide
CPT code 64600 (Injection treatment of nerve) is classified under Surgery (Endocrine/Nervous/Eye/Ear) with a global period indicator of 010. The 2026 Medicare Physician Fee Schedule assigns a work RVU of 3.4, a non-facility practice expense RVU of 11.57, and a malpractice RVU of 0.92, a total non-facility RVU of 15.89 and facility RVU of 6.8. With the current conversion factor of $33.4009, the national average non-facility reimbursement is approximately $545.5, though rates vary from $461.35 to $699.78 based on MAC locality and Geographic Practice Cost Indices (GPCIs).
When billing 64600, ensure documentation supports medical necessity and the specific components required for the code's level of service. For E/M codes, document MDM (medical decision-making) elements: problems addressed, data reviewed, and risk. For procedural codes, document the indication, technique, and any complications. Always verify NCCI edits before bundling 64600 with related codes; this code has 10 PTP bundling relationships on file (see table below).
Payment Status & Global Period
Active code (paid under MPFS)
10-day global period (minor procedure: pre-op day + procedure + 10 days post-op)
MUE Limit (Medically Unlikely Edits)
Submitting more than 2 units of 64600 for the same patient on the same date triggers automatic line denial unless an appropriate modifier and supporting documentation justify the higher quantity.
RVU Breakdown, CPT 64600
| Component | Non-Facility | Facility |
|---|---|---|
| Work RVU | 3.4 | 3.4 |
| Practice Expense RVU | 11.57 | 2.48 |
| Malpractice RVU | 0.92 | 0.92 |
| Total RVU | 15.89 | 6.8 |
| Conversion Factor | $33.4009 | |
2026 Medicare Reimbursement by State, CPT 64600
State-level averages across all MAC localities. Non-facility rates typically apply to office-based services; facility rates apply to hospital outpatient / inpatient.
| State | Non-Facility | Facility | Range (Non-Fac) | Localities |
|---|---|---|---|---|
| California | $591.57 | $232.31 | $555.51 - $699.78 | 29 |
| Florida | $561.12 | $256.49 | $529.19 - $593.57 | 3 |
| Georgia | $519.17 | $229.53 | $494.9 - $543.44 | 2 |
| Illinois | $546.09 | $252.72 | $514.42 - $573.26 | 4 |
| Michigan | $519.69 | $234.6 | $501.08 - $538.29 | 2 |
| North Carolina | $493.76 | $210.48 | $493.76 - $493.76 | 1 |
| New York | $591.85 | $253.13 | $502.29 - $637.38 | 5 |
| Ohio | $497.37 | $220.17 | $497.37 - $497.37 | 1 |
| Pennsylvania | $525.96 | $228.57 | $497.36 - $554.56 | 2 |
| Texas | $523.19 | $224.28 | $493.78 - $549.88 | 8 |
Source: CMS PFSRVU 2026 · Updated 2026-04-01. Full locality-level detail available for all 53 states, contact us for custom reports.
NCCI Bundling Edits, CPT 64600
Procedure-to-procedure (PTP) edits. If you bill any of these codes with 64600 on the same date of service, review the modifier indicator and payer policy before submission.
| Partner Code | Relationship | Modifier Allowed | Rationale |
|---|---|---|---|
| 0213T | Column 1 (primary), can be billed with modifier | No | Misuse of Column Two code with Column One code |
| 0216T | Column 1 (primary), can be billed with modifier | No | Misuse of Column Two code with Column One code |
| 0228T | Column 1 (primary), can be billed with modifier | No | Standards of medical/surgical practice |
| 0230T | Column 1 (primary), can be billed with modifier | No | Standards of medical/surgical practice |
| 0333T | Column 1 (primary), can be billed with modifier | No | CPT Manual or CMS manual coding instruction |
| 0464T | Column 1 (primary), can be billed with modifier | No | CPT Manual or CMS manual coding instruction |
| 0596T | Column 1 (primary), can be billed with modifier | Yes | Standards of medical/surgical practice |
| 0597T | Column 1 (primary), can be billed with modifier | Yes | Standards of medical/surgical practice |
| 0708T | Column 1 (primary), can be billed with modifier | Yes | Standards of medical/surgical practice |
| 0709T | Column 1 (primary), can be billed with modifier | Yes | Standards of medical/surgical practice |
Frequently Asked Questions, CPT 64600
What does CPT code 64600 mean? +
CPT code 64600 represents: Injection treatment of nerve. It's in the Surgery (Endocrine/Nervous/Eye/Ear) category with a global period of 010.
What is the Medicare reimbursement for CPT 64600? +
The 2026 Medicare national average non-facility payment for CPT 64600 is $545.5. Rates range from $461.35 to $699.78 across 53 states depending on MAC locality and GPCIs.
What modifiers can I use with CPT 64600? +
Surgery codes commonly use modifier 22 (increased procedural services), 50 (bilateral), 51 (multiple procedures), 52 (reduced services), 58/78/79 (staged, unplanned return, unrelated within global), 62 (co-surgeons), 80/82 (assistant surgeon), and 59 or the X{EPSU} subset for distinct procedural service.
What bundling edits apply to CPT 64600? +
This code has 10 NCCI PTP bundling relationships. See the NCCI Bundling section below for full list.
Get the full PayerReady toolkit
Free access to CPT/ICD-10 lookup, denial appeals, fee comparator, and claim auditing with credentialing enrollment.
Start free →Run this code through our claim audit tool
Check NCCI bundling, MUE limits, and modifier logic before submission.
Try the auditor →Did this page help?
Quick signal so we know what to improve.
If you want a code reference page that doesn't exist yet, email coding@payerready.com.
Tell us what's missing or wrong: coding@payerready.com. We respond within 5 business days.
Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on June 1, 2026.
Powered by 11K CPT · 98K ICD-10 · 860K MPFS rates · 4.5M NCCI edits · 9.5M NPIs. Our data methodology · About our coding team