CPT 22512
Global ZZZ ActiveVertebroplasty addl inject
CPT 22512 Billing & Documentation Guide
CPT code 22512 (Vertebroplasty addl inject) is classified under Surgery (Musculoskeletal) with a global period indicator of ZZZ. The 2026 Medicare Physician Fee Schedule assigns a work RVU of 3.9, a non-facility practice expense RVU of 17.53, and a malpractice RVU of 0.72, a total non-facility RVU of 22.15 and facility RVU of 5.43. With the current conversion factor of $33.4009, the national average non-facility reimbursement is approximately $764.58, though rates vary from $645.61 to $1001.8 based on MAC locality and Geographic Practice Cost Indices (GPCIs).
When billing 22512, ensure documentation supports medical necessity and the specific components required for the code's level of service. For E/M codes, document MDM (medical decision-making) elements: problems addressed, data reviewed, and risk. For procedural codes, document the indication, technique, and any complications. Always verify NCCI edits before bundling 22512 with related codes; this code has 10 PTP bundling relationships on file (see table below).
Payment Status & Global Period
Active code (paid under MPFS)
Add-on code (global concept does not apply)
MUE Limit (Medically Unlikely Edits)
Submitting more than 3 units of 22512 for the same patient on the same date triggers automatic line denial unless an appropriate modifier and supporting documentation justify the higher quantity.
RVU Breakdown, CPT 22512
| Component | Non-Facility | Facility |
|---|---|---|
| Work RVU | 3.9 | 3.9 |
| Practice Expense RVU | 17.53 | 0.81 |
| Malpractice RVU | 0.72 | 0.72 |
| Total RVU | 22.15 | 5.43 |
| Conversion Factor | $33.4009 | |
2026 Medicare Reimbursement by State, CPT 22512
State-level averages across all MAC localities. Non-facility rates typically apply to office-based services; facility rates apply to hospital outpatient / inpatient.
| State | Non-Facility | Facility | Range (Non-Fac) | Localities |
|---|---|---|---|---|
| California | $840.8 | $179.99 | $787.1 - $1001.8 | 29 |
| Florida | $764.55 | $204.22 | $726.16 - $800.61 | 3 |
| Georgia | $717.82 | $185.04 | $681.21 - $754.42 | 2 |
| Illinois | $742.43 | $202.82 | $702.43 - $775.12 | 4 |
| Michigan | $713.91 | $189.52 | $691.99 - $735.83 | 2 |
| North Carolina | $691.92 | $170.87 | $691.92 - $691.92 | 1 |
| New York | $822.34 | $199.32 | $703.41 - $879.44 | 5 |
| Ohio | $689.08 | $179.21 | $689.08 - $689.08 | 1 |
| Pennsylvania | $730.66 | $183.65 | $690.49 - $770.82 | 2 |
| Texas | $729.76 | $179.95 | $685.43 - $771.31 | 8 |
Source: CMS PFSRVU 2026 · Updated 2026-04-01. Full locality-level detail available for all 53 states, contact us for custom reports.
NCCI Bundling Edits, CPT 22512
Procedure-to-procedure (PTP) edits. If you bill any of these codes with 22512 on the same date of service, review the modifier indicator and payer policy before submission.
| Partner Code | Relationship | Modifier Allowed | Rationale |
|---|---|---|---|
| 0333T | Column 1 (primary), can be billed with modifier | No | Standards of medical/surgical practice |
| 0464T | Column 1 (primary), can be billed with modifier | No | Standards of medical/surgical practice |
| 10005 | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
| 10007 | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
| 10009 | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
| 10011 | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
| 10021 | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
| 10022 | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
| 11000 | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
| 11001 | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
Frequently Asked Questions, CPT 22512
What does CPT code 22512 mean? +
CPT code 22512 represents: Vertebroplasty addl inject. It's in the Surgery (Musculoskeletal) category with a global period of ZZZ.
What is the Medicare reimbursement for CPT 22512? +
The 2026 Medicare national average non-facility payment for CPT 22512 is $764.58. Rates range from $645.61 to $1001.8 across 53 states depending on MAC locality and GPCIs.
What modifiers can I use with CPT 22512? +
Surgery codes commonly use modifier 22 (increased procedural services), 50 (bilateral), 51 (multiple procedures), 52 (reduced services), 58/78/79 (staged, unplanned return, unrelated within global), 62 (co-surgeons), 80/82 (assistant surgeon), and 59 or the X{EPSU} subset for distinct procedural service.
What bundling edits apply to CPT 22512? +
This code has 10 NCCI PTP bundling relationships. See the NCCI Bundling section below for full list.
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on June 1, 2026.
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