CPT 22510
Global 010 ActivePerq cervicothoracic inject
CPT 22510 Billing & Documentation Guide
CPT code 22510 (Perq cervicothoracic inject) is classified under Surgery (Musculoskeletal) with a global period indicator of 010. The 2026 Medicare Physician Fee Schedule assigns a work RVU of 7.7, a non-facility practice expense RVU of 43.93, and a malpractice RVU of 1.16, a total non-facility RVU of 52.79 and facility RVU of 11.47. With the current conversion factor of $33.4009, the national average non-facility reimbursement is approximately $1826.93, though rates vary from $1537.55 to $2422.09 based on MAC locality and Geographic Practice Cost Indices (GPCIs).
When billing 22510, ensure documentation supports medical necessity and the specific components required for the code's level of service. For E/M codes, document MDM (medical decision-making) elements: problems addressed, data reviewed, and risk. For procedural codes, document the indication, technique, and any complications. Always verify NCCI edits before bundling 22510 with related codes; this code has 10 PTP bundling relationships on file (see table below).
Payment Status & Global Period
Active code (paid under MPFS)
10-day global period (minor procedure: pre-op day + procedure + 10 days post-op)
MUE Limit (Medically Unlikely Edits)
Submitting more than 1 units of 22510 for the same patient on the same date triggers automatic line denial unless an appropriate modifier and supporting documentation justify the higher quantity.
RVU Breakdown, CPT 22510
| Component | Non-Facility | Facility |
|---|---|---|
| Work RVU | 7.7 | 7.7 |
| Practice Expense RVU | 43.93 | 2.61 |
| Malpractice RVU | 1.16 | 1.16 |
| Total RVU | 52.79 | 11.47 |
| Conversion Factor | $33.4009 | |
2026 Medicare Reimbursement by State, CPT 22510
State-level averages across all MAC localities. Non-facility rates typically apply to office-based services; facility rates apply to hospital outpatient / inpatient.
| State | Non-Facility | Facility | Range (Non-Fac) | Localities |
|---|---|---|---|---|
| California | $2023.64 | $390.57 | $1890.49 - $2422.09 | 29 |
| Florida | $1804.8 | $420.08 | $1718.16 - $1882.63 | 3 |
| Georgia | $1703.74 | $387.1 | $1612.2 - $1795.27 | 2 |
| Illinois | $1749.91 | $416.36 | $1657.39 - $1834.56 | 4 |
| Michigan | $1689.52 | $393.58 | $1640.58 - $1738.46 | 2 |
| North Carolina | $1650.94 | $363.28 | $1650.94 - $1650.94 | 1 |
| New York | $1958.98 | $419.31 | $1678.36 - $2090.22 | 5 |
| Ohio | $1635.89 | $375.83 | $1635.89 - $1635.89 | 1 |
| Pennsylvania | $1738.14 | $386.31 | $1640.78 - $1835.5 | 2 |
| Texas | $1739.15 | $380.41 | $1628.43 - $1844.43 | 8 |
Source: CMS PFSRVU 2026 · Updated 2026-04-01. Full locality-level detail available for all 53 states, contact us for custom reports.
NCCI Bundling Edits, CPT 22510
Procedure-to-procedure (PTP) edits. If you bill any of these codes with 22510 on the same date of service, review the modifier indicator and payer policy before submission.
| Partner Code | Relationship | Modifier Allowed | Rationale |
|---|---|---|---|
| 01935 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 01936 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 01937 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 01938 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 01939 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 01940 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 01941 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 01942 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 0213T | Column 1 (primary), can be billed with modifier | No | Misuse of Column Two code with Column One code |
| 0216T | Column 1 (primary), can be billed with modifier | No | Misuse of Column Two code with Column One code |
Frequently Asked Questions, CPT 22510
What does CPT code 22510 mean? +
CPT code 22510 represents: Perq cervicothoracic inject. It's in the Surgery (Musculoskeletal) category with a global period of 010.
What is the Medicare reimbursement for CPT 22510? +
The 2026 Medicare national average non-facility payment for CPT 22510 is $1826.93. Rates range from $1537.55 to $2422.09 across 53 states depending on MAC locality and GPCIs.
What modifiers can I use with CPT 22510? +
Surgery codes commonly use modifier 22 (increased procedural services), 50 (bilateral), 51 (multiple procedures), 52 (reduced services), 58/78/79 (staged, unplanned return, unrelated within global), 62 (co-surgeons), 80/82 (assistant surgeon), and 59 or the X{EPSU} subset for distinct procedural service.
What bundling edits apply to CPT 22510? +
This code has 10 NCCI PTP bundling relationships. See the NCCI Bundling section below for full list.
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on May 31, 2026.
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