ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 Z22.7

Billable / Specific

Latent tuberculosis

Z22
Block
1
Synonyms
129
LCDs
4
Payer Policies
0
Linked CPTs

About ICD-10-CM Z22.7

ICD-10-CM code Z22.7 represents Latent tuberculosis. This is a billable/specific code in the Factors Influencing Health Status chapter (block Z22). The 2026 edition of ICD-10-CM Z22.7 became effective on October 1, 2025.

Inclusion Terms / Approximate Synonyms

Clinical terms and conditions classified under Z22.7. Per CMS ICD-10-CM Tabular 2026.

  • Latent tuberculosis infection (LTBI)

Type 1 Excludes

Pure excludes, these codes can never be coded together with Z22.7. The conditions are mutually exclusive (e.g., congenital vs acquired forms).

  • nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis (R76.12)
  • nonspecific reaction to tuberculin skin test without active tuberculosis (R76.11)

Medicare LCD Coverage for Z22.7

Local Coverage Determinations (LCDs) from CMS MACs that list Z22.7 as a covered diagnosis.

129 LCDs

Showing top 10 of 129 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Pharmacogenomics Testing
Article ID: 58801, Effective: 2026-01-01 00:00:00, 578 covered, 0 non-covered
CPT 81227 →
CMS LCD: Billing and Coding: Pharmacogenomics Testing
Article ID: 58801, Effective: 2026-01-01 00:00:00, 578 covered, 0 non-covered
CPT 81328 →
CMS LCD: Billing and Coding: Pharmacogenomics Testing
Article ID: 58801, Effective: 2026-01-01 00:00:00, 578 covered, 0 non-covered
CPT 81335 →
CMS LCD: Billing and Coding: Pharmacogenomics Testing
Article ID: 58801, Effective: 2026-01-01 00:00:00, 578 covered, 0 non-covered
CPT 0071U →
CMS LCD: Billing and Coding: Pharmacogenomics Testing
Article ID: 58801, Effective: 2026-01-01 00:00:00, 578 covered, 0 non-covered
CPT 81383 →
CMS LCD: Billing and Coding: Pharmacogenomics Testing
Article ID: 58801, Effective: 2026-01-01 00:00:00, 578 covered, 0 non-covered
CPT 81418 →
CMS LCD: Billing and Coding: Pharmacogenomics Testing
Article ID: 58801, Effective: 2026-01-01 00:00:00, 578 covered, 0 non-covered
CPT 0073U →
CMS LCD: Billing and Coding: Pharmacogenomics Testing
Article ID: 58801, Effective: 2026-01-01 00:00:00, 578 covered, 0 non-covered
CPT 81283 →
CMS LCD: Billing and Coding: Pharmacogenomics Testing
Article ID: 58801, Effective: 2026-01-01 00:00:00, 578 covered, 0 non-covered
CPT 81408 →
CMS LCD: Billing and Coding: Pharmacogenomics Testing
Article ID: 58801, Effective: 2026-01-01 00:00:00, 578 covered, 0 non-covered
CPT 81355 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing Z22.7.

4 policies

3 Medicare

Billing and Coding: Pharmacogenomics Testing
Policy ID: ART-58801
Billing and Coding: Pharmacogenomics Testing
Policy ID: ART-58812
Billing and Coding: Pharmacogenomic Testing
Policy ID: ART-59915

1 Aetna

Tuberculosis Testing
Policy ID: CPB-0471

CPT Codes Commonly Billed with Z22.7

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

No procedure linkages on file for Z22.7

We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.

Codes Adjacent To Z22.7

Other codes in section Z20-Z29 (Persons with potential health hazards related to communicable diseases).

Z20 Contact with and (suspected) exposure to communicable diseases (non-billable) Z20.0 Contact with and (suspected) exposure to intestinal infectious diseases (non-billable) Z20.01 Contact with and (suspected) exposure to intestinal infectious diseases due to Escherichia coli (E. coli) Z20.09 Contact with and (suspected) exposure to other intestinal infectious diseases Z20.1 Contact with and (suspected) exposure to tuberculosis Z20.2 Contact with and (suspected) exposure to infections with a predominantly sexual mode of transmission Z20.3 Contact with and (suspected) exposure to rabies Z20.4 Contact with and (suspected) exposure to rubella Z20.5 Contact with and (suspected) exposure to viral hepatitis Z20.6 Contact with and (suspected) exposure to human immunodeficiency virus [HIV] Z20.7 Contact with and (suspected) exposure to pediculosis, acariasis and other infestations Z20.8 Contact with and (suspected) exposure to other communicable diseases (non-billable) Z20.81 Contact with and (suspected) exposure to other bacterial communicable diseases (non-billable) Z20.810 Contact with and (suspected) exposure to anthrax Z20.811 Contact with and (suspected) exposure to meningococcus Z20.818 Contact with and (suspected) exposure to other bacterial communicable diseases Z20.82 Contact with and (suspected) exposure to other viral communicable diseases (non-billable) Z20.820 Contact with and (suspected) exposure to varicella Z20.821 Contact with and (suspected) exposure to Zika virus Z20.822 Contact with and (suspected) exposure to COVID-19

ICD-10 Z22.7, Billing FAQ

Is ICD-10 code Z22.7 billable? +

Yes, Z22.7 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What other names or terms map to Z22.7? +

ICD-10 Z22.7 includes: Latent tuberculosis infection (LTBI).

What codes are Type 1 Excludes for Z22.7? +

Type 1 Excludes (never code together with Z22.7): nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis (R76.12); nonspecific reaction to tuberculin skin test without active tuberculosis (R76.11)

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on May 31, 2026.

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