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ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 M25.561

Billable / Specific

Pain in right knee

M25
Block
0
Synonyms
591
LCDs
27
Payer Policies
3
Linked CPTs

About ICD-10-CM M25.561

ICD-10-CM code M25.561 represents Pain in right knee. This is a billable/specific code in the Musculoskeletal and Connective Tissue chapter (block M25). The 2026 edition of ICD-10-CM M25.561 became effective on October 1, 2025.

Medicare LCD Coverage for M25.561

Local Coverage Determinations (LCDs) from CMS MACs that list M25.561 as a covered diagnosis.

591 LCDs

Showing top 10 of 591 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Chiropractic Services
Article ID: 56273, Effective: 2025-08-28 00:00:00, 315 covered, 0 non-covered
CPT 98942 →
CMS LCD: Billing and Coding: Chiropractic Services
Article ID: 56273, Effective: 2025-08-28 00:00:00, 315 covered, 0 non-covered
CPT 98940 →
CMS LCD: Billing and Coding: Chiropractic Services
Article ID: 56273, Effective: 2025-08-28 00:00:00, 315 covered, 0 non-covered
CPT 98941 →
CMS LCD: Billing and Coding: Chiropractic Services
Article ID: 56273, Effective: 2025-08-28 00:00:00, 315 covered, 0 non-covered
CPT 98943 →
CMS LCD: Billing and Coding: Continuous Peripheral Nerve Blocks (CPNB)
Article ID: 56607, Effective: 2025-10-01 00:00:00, 604 covered, 0 non-covered
CPT 64416 →
CMS LCD: Billing and Coding: Continuous Peripheral Nerve Blocks (CPNB)
Article ID: 56607, Effective: 2025-10-01 00:00:00, 604 covered, 0 non-covered
CPT 64446 →
CMS LCD: Billing and Coding: Continuous Peripheral Nerve Blocks (CPNB)
Article ID: 56607, Effective: 2025-10-01 00:00:00, 604 covered, 0 non-covered
CPT 64448 →
CMS LCD: Billing and Coding: Continuous Peripheral Nerve Blocks (CPNB)
Article ID: 56607, Effective: 2025-10-01 00:00:00, 604 covered, 0 non-covered
CPT 64449 →
CMS LCD: Billing and Coding: Lower Extremity Major Joint Replacement (Hip and Knee)
Article ID: 56796, Effective: 2026-01-01 00:00:00, 1355 covered, 1 non-covered
CPT 27134 →
CMS LCD: Billing and Coding: Lower Extremity Major Joint Replacement (Hip and Knee)
Article ID: 56796, Effective: 2026-01-01 00:00:00, 1355 covered, 1 non-covered
CPT 27130 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing M25.561.

27 policies

3 Cigna

Acupuncture - (CPG024)
Policy ID: CPG024_ACUPUNCTURE
Electrodiagnostic Testing (EMG/NCV) - (CPG129)
Policy ID: CPG129_EMG_NCV_SSEP
Peripheral Nerve Destruction for Pain Conditions - (0525) ---- future effective policy
Policy ID: MM_0525

5 Medicare

Billing and Coding: Home Health Occupational Therapy
Policy ID: ART-53057
Billing and Coding: Home Health Physical Therapy
Policy ID: ART-53058
Billing and Coding: Outpatient Occupational Therapy
Policy ID: ART-53064
Billing and Coding: Outpatient Physical Therapy
Policy ID: ART-53065
Billing and Coding: Urine Drug Testing
Policy ID: ART-54799

CPT Codes Commonly Billed with M25.561

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

3 linkages
  • 73721 MRI knee without contrast — knee pain, meniscal derangement, meniscal tear, patellar tendinitis, knee OA, ACL injury Orthopedics
  • 86790 CMS LCD: Billing and Coding: Zika Virus Testing by PCR and ELISA Methods CMS LCD
  • 86794 CMS LCD: Billing and Coding: Zika Virus Testing by PCR and ELISA Methods CMS LCD

Convert M25.561 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
M25.561 71946 10000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 M25.561, Billing FAQ

Is ICD-10 code M25.561 billable? +

Yes, M25.561 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What CPT codes are commonly billed with M25.561? +

Procedures frequently paired with M25.561 include: 73721, 86790, 86794.

What ICD-9 codes does M25.561 map to? +

Per CMS GEMs, M25.561 maps to ICD-9 codes: 71946. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on July 16, 2026.

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