ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 E88.02

Billable / Specific CC

Plasminogen deficiency

E88
Block
4
Synonyms
70
LCDs
3
Payer Policies
0
Linked CPTs

About ICD-10-CM E88.02

ICD-10-CM code E88.02 represents Plasminogen deficiency. This is a billable/specific code in the Endocrine, Nutritional, and Metabolic chapter (block E88). The 2026 edition of ICD-10-CM E88.02 became effective on October 1, 2025.

Coding Tips for E88.02

Specialist guidance from the PayerReady Medical Coding Team. Specificity warnings, HCC capture rules, sequencing notes.

Inpatient DRG impact: CC

E88.02 is designated CC for MS-DRG grouping. On inpatient claims, this code can shift the DRG to the with-CC variant when documented as a present-on-admission secondary diagnosis. Hospital CDI programs flag CC opportunities during chart review. Failure to capture this code may leave 30 to 80 percent of the inpatient stay revenue unrealized.

Inclusion Terms / Approximate Synonyms

Clinical terms and conditions classified under E88.02. Per CMS ICD-10-CM Tabular 2026.

  • Dysplasminogenemia
  • Hypoplasminogenemia
  • Type 1 plasminogen deficiency
  • Type 2 plasminogen deficiency

Use Additional Code

When coding E88.02, also report these additional codes when applicable.

  • code for associated findings, such as:
  • hydrocephalus (G91.4)
  • otitis media (H67.-)
  • respiratory disorder related to plasminogen deficiency (J99)

Coding Notes

Code Also

  • , if applicable, ligneous conjunctivitis (H10.51-)

Inpatient DRG Impact, CC

codes Plasminogen deficiency. As a Complication/Comorbidity (CC), this contributes to DRG severity adjustment when documented alongside the principal diagnosis.

Medicare LCD Coverage for E88.02

Local Coverage Determinations (LCDs) from CMS MACs that list E88.02 as a covered diagnosis.

70 LCDs

Showing top 10 of 70 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Respiratory Care
Article ID: 57224, Effective: 2026-01-01 00:00:00, 901 covered, 0 non-covered
CPT 94660 →
CMS LCD: Billing and Coding: Respiratory Care
Article ID: 57224, Effective: 2026-01-01 00:00:00, 901 covered, 0 non-covered
CPT 94726 →
CMS LCD: Billing and Coding: Respiratory Care
Article ID: 57224, Effective: 2026-01-01 00:00:00, 901 covered, 0 non-covered
CPT 94664 →
CMS LCD: Billing and Coding: Respiratory Care
Article ID: 57224, Effective: 2026-01-01 00:00:00, 901 covered, 0 non-covered
CPT 94618 →
CMS LCD: Billing and Coding: Respiratory Care
Article ID: 57224, Effective: 2026-01-01 00:00:00, 901 covered, 0 non-covered
CPT 94772 →
CMS LCD: Billing and Coding: Respiratory Care
Article ID: 57224, Effective: 2026-01-01 00:00:00, 901 covered, 0 non-covered
CPT 94642 →
CMS LCD: Billing and Coding: Respiratory Care
Article ID: 57224, Effective: 2026-01-01 00:00:00, 901 covered, 0 non-covered
CPT G0238 →
CMS LCD: Billing and Coding: Respiratory Care
Article ID: 57224, Effective: 2026-01-01 00:00:00, 901 covered, 0 non-covered
CPT 94004 →
CMS LCD: Billing and Coding: Respiratory Care
Article ID: 57224, Effective: 2026-01-01 00:00:00, 901 covered, 0 non-covered
CPT 94668 →
CMS LCD: Billing and Coding: Respiratory Care
Article ID: 57224, Effective: 2026-01-01 00:00:00, 901 covered, 0 non-covered
CPT 94680 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing E88.02.

3 policies

1 Cigna

Flow Cytometry - (0538)
Policy ID: MM_0538

2 Medicare

Billing and Coding: Respiratory Therapy (Respiratory Care)
Policy ID: ART-56717
Billing and Coding: Respiratory Care
Policy ID: ART-57224

CPT Codes Commonly Billed with E88.02

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

No procedure linkages on file for E88.02

We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.

ICD-10 E88.02, Billing FAQ

Is ICD-10 code E88.02 billable? +

Yes, E88.02 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What other names or terms map to E88.02? +

ICD-10 E88.02 includes: Dysplasminogenemia; Hypoplasminogenemia; Type 1 plasminogen deficiency, and 1 more clinical synonyms.

Is E88.02 a CC or MCC for inpatient DRG? +

Yes, this code is designated as CC. Documenting as a secondary diagnosis on inpatient claims can shift the DRG to a higher-weighted category.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on May 31, 2026.

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