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ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 E78.3

Billable / Specific

Hyperchylomicronemia

E78
Block
4
Synonyms
85
LCDs
9
Payer Policies
10
Linked CPTs

About ICD-10-CM E78.3

ICD-10-CM code E78.3 represents Hyperchylomicronemia. This is a billable/specific code in the Endocrine, Nutritional, and Metabolic chapter (block E78). The 2026 edition of ICD-10-CM E78.3 became effective on October 1, 2025.

Inclusion Terms / Approximate Synonyms

Clinical terms and conditions classified under E78.3. Per CMS ICD-10-CM Tabular 2026.

  • Chylomicron retention disease
  • Fredrickson's hyperlipoproteinemia, type I or V
  • Hyperlipidemia, group D
  • Mixed hyperglyceridemia

Medicare LCD Coverage for E78.3

Local Coverage Determinations (LCDs) from CMS MACs that list E78.3 as a covered diagnosis.

85 LCDs

Showing top 10 of 85 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Homocysteine Level, Serum
Article ID: 56675, Effective: 2024-10-01 00:00:00, 550 covered, 0 non-covered
CPT 83090 →
CMS LCD: Billing and Coding: Bariatric Surgical Management of Morbid Obesity
Article ID: 56422, Effective: 2026-01-01 00:00:00, 270 covered, 1 non-covered
CPT 43888 →
CMS LCD: Billing and Coding: Bariatric Surgical Management of Morbid Obesity
Article ID: 56422, Effective: 2026-01-01 00:00:00, 270 covered, 1 non-covered
CPT 43846 →
CMS LCD: Billing and Coding: Bariatric Surgical Management of Morbid Obesity
Article ID: 56422, Effective: 2026-01-01 00:00:00, 270 covered, 1 non-covered
CPT 43771 →
CMS LCD: Billing and Coding: Bariatric Surgical Management of Morbid Obesity
Article ID: 56422, Effective: 2026-01-01 00:00:00, 270 covered, 1 non-covered
CPT 43659 →
CMS LCD: Billing and Coding: Bariatric Surgical Management of Morbid Obesity
Article ID: 56422, Effective: 2026-01-01 00:00:00, 270 covered, 1 non-covered
CPT 43845 →
CMS LCD: Billing and Coding: Bariatric Surgical Management of Morbid Obesity
Article ID: 56422, Effective: 2026-01-01 00:00:00, 270 covered, 1 non-covered
CPT 43886 →
CMS LCD: Billing and Coding: Bariatric Surgical Management of Morbid Obesity
Article ID: 56422, Effective: 2026-01-01 00:00:00, 270 covered, 1 non-covered
CPT 43774 →
CMS LCD: Billing and Coding: Bariatric Surgical Management of Morbid Obesity
Article ID: 56422, Effective: 2026-01-01 00:00:00, 270 covered, 1 non-covered
CPT 43887 →
CMS LCD: Billing and Coding: Bariatric Surgical Management of Morbid Obesity
Article ID: 56422, Effective: 2026-01-01 00:00:00, 270 covered, 1 non-covered
CPT 43847 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing E78.3.

9 policies

5 Medicare

Billing and Coding: Assays for Vitamins and Metabolic Function
Policy ID: ART-56416
Billing and Coding: Bariatric Surgical Management of Morbid Obesity
Policy ID: ART-56422
Billing and Coding: Homocysteine Level, Serum
Policy ID: ART-56675
Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment
Policy ID: ART-56943
Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment
Policy ID: ART-57037

CPT Codes Commonly Billed with E78.3

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

10 linkages
  • 83090 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
  • 83700 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
  • 82172 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
  • 86141 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
  • 83701 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
  • 83719 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
  • 83721 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
  • 83698 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
  • 83695 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
  • 83704 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD

Convert E78.3 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
E78.3 2723 00000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 E78.3, Billing FAQ

Is ICD-10 code E78.3 billable? +

Yes, E78.3 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What other names or terms map to E78.3? +

ICD-10 E78.3 includes: Chylomicron retention disease; Fredrickson's hyperlipoproteinemia, type I or V; Hyperlipidemia, group D, and 1 more clinical synonyms.

What CPT codes are commonly billed with E78.3? +

Procedures frequently paired with E78.3 include: 83090, 83700, 82172, 86141, 83701.

What ICD-9 codes does E78.3 map to? +

Per CMS GEMs, E78.3 maps to ICD-9 codes: 2723. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on July 16, 2026.

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