ICD-10 E78.2
Billable / SpecificMixed hyperlipidemia
About ICD-10-CM E78.2
ICD-10-CM code E78.2 represents Mixed hyperlipidemia. This is a billable/specific code in the Endocrine, Nutritional, and Metabolic chapter (block E78). The 2026 edition of ICD-10-CM E78.2 became effective on October 1, 2025.
Inclusion Terms / Approximate Synonyms
Clinical terms and conditions classified under E78.2. Per CMS ICD-10-CM Tabular 2026.
- Broad- or floating-betalipoproteinemia
- Combined hyperlipidemia NOS
- Elevated cholesterol with elevated triglycerides NEC
- Fredrickson's hyperlipoproteinemia, type IIb or III
- Hyperbetalipoproteinemia with prebetalipoproteinemia
- Hypercholesteremia with endogenous hyperglyceridemia
- Hyperlipidemia, group C
- Tubo-eruptive xanthoma
- Xanthoma tuberosum
Type 1 Excludes
Pure excludes, these codes can never be coded together with E78.2. The conditions are mutually exclusive (e.g., congenital vs acquired forms).
- cerebrotendinous cholesterosis [van Bogaert-Scherer- Epstein] (E75.5)
- familial combined hyperlipidemia (E78.49)
Medicare LCD Coverage for E78.2
Local Coverage Determinations (LCDs) from CMS MACs that list E78.2 as a covered diagnosis.
Showing top 10 of 228 total . Click a CPT for full coverage scope.
Commercial Payer Coverage
Coverage policies from major commercial payers referencing E78.2.
1 Cigna
5 Medicare
2 Aetna
CPT Codes Commonly Billed with E78.2
Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.
- 80061 Lipid panel — hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, CAD, HTN, diabetes, lipid screening, family hx heart disease, obesity Laboratory
- 83090 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
- 83700 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
- 82172 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
- 86141 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
- 83701 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
- 83719 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
- 83721 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
- 83698 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
- 83695 CMS LCD: Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment CMS LCD
Convert E78.2 to ICD-9-CM
Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.
| ICD-10 | ICD-9 | Mapping Flags |
|---|---|---|
| E78.2 | 2722 | 00000 |
Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).
Codes Adjacent To E78.2
Other codes in section E70-E88 (Metabolic disorders).
ICD-10 E78.2, Billing FAQ
Is ICD-10 code E78.2 billable? +
Yes, E78.2 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.
What other names or terms map to E78.2? +
ICD-10 E78.2 includes: Broad- or floating-betalipoproteinemia; Combined hyperlipidemia NOS; Elevated cholesterol with elevated triglycerides NEC, and 6 more clinical synonyms.
What codes are Type 1 Excludes for E78.2? +
Type 1 Excludes (never code together with E78.2): cerebrotendinous cholesterosis [van Bogaert-Scherer- Epstein] (E75.5); familial combined hyperlipidemia (E78.49)
What CPT codes are commonly billed with E78.2? +
Procedures frequently paired with E78.2 include: 80061, 83090, 83700, 82172, 86141.
What ICD-9 codes does E78.2 map to? +
Per CMS GEMs, E78.2 maps to ICD-9 codes: 2722. Useful for legacy data review and historical claim analysis.
Get the full PayerReady toolkit
Free access to CPT/ICD-10 lookup, denial appeals, fee comparator, and claim auditing with credentialing enrollment.
Start free →Run this code through our claim audit tool
Check NCCI bundling, MUE limits, and modifier logic before submission.
Try the auditor →Did this page help?
Quick signal so we know what to improve.
If you want a code reference page that doesn't exist yet, email coding@payerready.com.
Tell us what's missing or wrong: coding@payerready.com. We respond within 5 business days.
Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on July 16, 2026.
Powered by 11K CPT · 98K ICD-10 · 860K MPFS rates · 4.5M NCCI edits · 9.5M NPIs. Our data methodology · About our coding team