ICD-10 E34.321
Billable / SpecificPrimary insulin-like growth factor-1 (IGF-1) deficiency
About ICD-10-CM E34.321
ICD-10-CM code E34.321 represents Primary insulin-like growth factor-1 (IGF-1) deficiency. This is a billable/specific code in the Endocrine, Nutritional, and Metabolic chapter (block E34). The 2026 edition of ICD-10-CM E34.321 became effective on October 1, 2025.
Inclusion Terms / Approximate Synonyms
Clinical terms and conditions classified under E34.321. Per CMS ICD-10-CM Tabular 2026.
- Acid-labile subunit gene (IGFALS) defect
- Growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies
- Growth hormone insensitivity syndrome (GHIS)
- Insulin-like growth factor 1 gene (IGF1) defect
- Laron type short stature
- Severe primary insulin-like growth factor-1 deficiency (SPIGFD)
- Signal transducer and activator of transcription 5B gene (STAT5b) defect
Medicare LCD Coverage for E34.321
Local Coverage Determinations (LCDs) from CMS MACs that list E34.321 as a covered diagnosis.
Showing top 10 of 28 total . Click a CPT for full coverage scope.
Commercial Payer Coverage
Coverage policies from major commercial payers referencing E34.321.
1 Medicare
1 Aetna
CPT Codes Commonly Billed with E34.321
Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.
We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.
Codes Adjacent To E34.321
Other codes in section E20-E35 (Disorders of other endocrine glands).
ICD-10 E34.321, Billing FAQ
Is ICD-10 code E34.321 billable? +
Yes, E34.321 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.
What other names or terms map to E34.321? +
ICD-10 E34.321 includes: Acid-labile subunit gene (IGFALS) defect; Growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies; Growth hormone insensitivity syndrome (GHIS), and 4 more clinical synonyms.
Get the full PayerReady toolkit
Free access to CPT/ICD-10 lookup, denial appeals, fee comparator, and claim auditing with credentialing enrollment.
Start free →Run this code through our claim audit tool
Check NCCI bundling, MUE limits, and modifier logic before submission.
Try the auditor →Did this page help?
Quick signal so we know what to improve.
If you want a code reference page that doesn't exist yet, email coding@payerready.com.
Tell us what's missing or wrong: coding@payerready.com. We respond within 5 business days.
Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on May 31, 2026.
Powered by 11K CPT · 98K ICD-10 · 860K MPFS rates · 4.5M NCCI edits · 9.5M NPIs. Our data methodology · About our coding team