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ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 E28.310

Billable / Specific

Symptomatic premature menopause

E28
Block
1
Synonyms
36
LCDs
6
Payer Policies
13
Linked CPTs

About ICD-10-CM E28.310

ICD-10-CM code E28.310 represents Symptomatic premature menopause. This is a billable/specific code in the Endocrine, Nutritional, and Metabolic chapter (block E28). The 2026 edition of ICD-10-CM E28.310 became effective on October 1, 2025.

Inclusion Terms / Approximate Synonyms

Clinical terms and conditions classified under E28.310. Per CMS ICD-10-CM Tabular 2026.

  • Symptoms such as flushing, sleeplessness, headache, lack of concentration, associated with premature menopause

Medicare LCD Coverage for E28.310

Local Coverage Determinations (LCDs) from CMS MACs that list E28.310 as a covered diagnosis.

36 LCDs

Showing top 10 of 36 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74170 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74177 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74160 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74178 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74150 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 72194 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74176 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 72192 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 72193 →
CMS LCD: Billing and Coding: Ibandronate Sodium
Article ID: 52421, Effective: 2023-10-01 00:00:00, 254 covered, 0 non-covered
CPT J1740 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing E28.310.

6 policies

4 Medicare

Billing and Coding: Ibandronate Sodium
Policy ID: ART-52421
Billing and Coding: CT of the Abdomen and Pelvis
Policy ID: ART-56421
Billing and Coding: Bone Mass Measurement
Policy ID: ART-57132
Billing and Coding: Bone Mass Measurement
Policy ID: ART-59040

2 Aetna

Infertility
Policy ID: CPB-0327
Progestins
Policy ID: CPB-0510

CPT Codes Commonly Billed with E28.310

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

13 linkages
  • 77081 CMS LCD: Billing and Coding: Bone Mass Measurement CMS LCD
  • 0556T CMS LCD: Billing and Coding: Bone Mass Measurement CMS LCD
  • 78350 CMS LCD: Billing and Coding: Bone Mass Measurement CMS LCD
  • 0554T CMS LCD: Billing and Coding: Bone Mass Measurement CMS LCD
  • 77085 CMS LCD: Billing and Coding: Bone Mass Measurement CMS LCD
  • 0558T CMS LCD: Billing and Coding: Bone Mass Measurement CMS LCD
  • 0555T CMS LCD: Billing and Coding: Bone Mass Measurement CMS LCD
  • 0557T CMS LCD: Billing and Coding: Bone Mass Measurement CMS LCD
  • 77078 CMS LCD: Billing and Coding: Bone Mass Measurement CMS LCD
  • 76977 CMS LCD: Billing and Coding: Bone Mass Measurement CMS LCD

Convert E28.310 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
E28.310 25631 10000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 E28.310, Billing FAQ

Is ICD-10 code E28.310 billable? +

Yes, E28.310 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What other names or terms map to E28.310? +

ICD-10 E28.310 includes: Symptoms such as flushing, sleeplessness, headache, lack of concentration, associated with premature menopause.

What CPT codes are commonly billed with E28.310? +

Procedures frequently paired with E28.310 include: 77081, 0556T, 78350, 0554T, 77085.

What ICD-9 codes does E28.310 map to? +

Per CMS GEMs, E28.310 maps to ICD-9 codes: 25631. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on July 16, 2026.

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