ICD-10 E22.0
Billable / Specific HCC v28: 23Acromegaly and pituitary gigantism
About ICD-10-CM E22.0
ICD-10-CM code E22.0 represents Acromegaly and pituitary gigantism. This is a billable/specific code in the Endocrine, Nutritional, and Metabolic chapter (block E22). The 2026 edition of ICD-10-CM E22.0 became effective on October 1, 2025.
Coding Tips for E22.0
Specialist guidance from the PayerReady Medical Coding Team. Specificity warnings, HCC capture rules, sequencing notes.
E22.0 is a CMS-HCC v28 risk-adjustment code (category 23). To count for the patient Risk Adjustment Factor (RAF), document the diagnosis with MEAT language each calendar year: Monitored, Evaluated, Assessed, Treated. A diagnosis on the problem list alone does not satisfy CMS RADV audit standards. Include the diagnosis in the assessment with current status and current treatment plan.
Inclusion Terms / Approximate Synonyms
Clinical terms and conditions classified under E22.0. Per CMS ICD-10-CM Tabular 2026.
- Overproduction of growth hormone
Type 1 Excludes
Pure excludes, these codes can never be coded together with E22.0. The conditions are mutually exclusive (e.g., congenital vs acquired forms).
- constitutional gigantism (E34.4)
- constitutional tall stature (E34.4)
- increased secretion from endocrine pancreas of growth hormone-releasing hormone (E16.8)
Medicare Advantage HCC Impact
Capture this diagnosis annually for accurate risk adjustment. Missed HCC captures are the #1 revenue leak in Medicare Advantage risk programs.
Medicare LCD Coverage for E22.0
Local Coverage Determinations (LCDs) from CMS MACs that list E22.0 as a covered diagnosis.
Showing top 10 of 131 total . Click a CPT for full coverage scope.
Commercial Payer Coverage
Coverage policies from major commercial payers referencing E22.0.
5 Medicare
2 Aetna
CPT Codes Commonly Billed with E22.0
Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.
- J2353 CMS LCD: Billing and Coding: Octreotide Acetate for Injectable Suspension (Sandostatin� LAR Depot) CMS LCD
Convert E22.0 to ICD-9-CM
Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.
| ICD-10 | ICD-9 | Mapping Flags |
|---|---|---|
| E22.0 | 2530 | 10000 |
Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).
Codes Adjacent To E22.0
Other codes in section E20-E35 (Disorders of other endocrine glands).
ICD-10 E22.0, Billing FAQ
Is ICD-10 code E22.0 billable? +
Yes, E22.0 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.
What other names or terms map to E22.0? +
ICD-10 E22.0 includes: Overproduction of growth hormone.
What codes are Type 1 Excludes for E22.0? +
Type 1 Excludes (never code together with E22.0): constitutional gigantism (E34.4); constitutional tall stature (E34.4); increased secretion from endocrine pancreas of growth hormone-releasing hormone (E16.8)
Does E22.0 affect Medicare Advantage HCC risk adjustment? +
Yes. E22.0 maps to CMS-HCC v28 category 23. Capture this diagnosis annually for accurate Medicare Advantage risk score.
What CPT codes are commonly billed with E22.0? +
Procedures frequently paired with E22.0 include: J2353.
What ICD-9 codes does E22.0 map to? +
Per CMS GEMs, E22.0 maps to ICD-9 codes: 2530. Useful for legacy data review and historical claim analysis.
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on May 31, 2026.
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