ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 D64.81

Billable / Specific

Anemia due to antineoplastic chemotherapy

D64
Block
1
Synonyms
562
LCDs
8
Payer Policies
0
Linked CPTs

About ICD-10-CM D64.81

ICD-10-CM code D64.81 represents Anemia due to antineoplastic chemotherapy. This is a billable/specific code in the Blood and Blood-forming Organs chapter (block D64). The 2026 edition of ICD-10-CM D64.81 became effective on October 1, 2025.

Inclusion Terms / Approximate Synonyms

Clinical terms and conditions classified under D64.81. Per CMS ICD-10-CM Tabular 2026.

  • Antineoplastic chemotherapy induced anemia

Type 2 Excludes

Not included here, the excluded code is not part of D64.81, but a patient may have both conditions at the same time. Both codes may be coded together when applicable.

  • anemia in neoplastic disease (D63.0)
  • aplastic anemia due to antineoplastic chemotherapy (D61.1)

Medicare LCD Coverage for D64.81

Local Coverage Determinations (LCDs) from CMS MACs that list D64.81 as a covered diagnosis.

562 LCDs

Showing top 10 of 562 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
Article ID: 58761, Effective: 2026-03-12 00:00:00, 851 covered, 0 non-covered
CPT 87555 →
CMS LCD: Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
Article ID: 58761, Effective: 2026-03-12 00:00:00, 851 covered, 0 non-covered
CPT 87653 →
CMS LCD: Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
Article ID: 58761, Effective: 2026-03-12 00:00:00, 851 covered, 0 non-covered
CPT 87486 →
CMS LCD: Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
Article ID: 58761, Effective: 2026-03-12 00:00:00, 851 covered, 0 non-covered
CPT 87626 →
CMS LCD: Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
Article ID: 58761, Effective: 2026-03-12 00:00:00, 851 covered, 0 non-covered
CPT 0109U →
CMS LCD: Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
Article ID: 58761, Effective: 2026-03-12 00:00:00, 851 covered, 0 non-covered
CPT 87516 →
CMS LCD: Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
Article ID: 58761, Effective: 2026-03-12 00:00:00, 851 covered, 0 non-covered
CPT 87517 →
CMS LCD: Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
Article ID: 58761, Effective: 2026-03-12 00:00:00, 851 covered, 0 non-covered
CPT 87528 →
CMS LCD: Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
Article ID: 58761, Effective: 2026-03-12 00:00:00, 851 covered, 0 non-covered
CPT 87476 →
CMS LCD: Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
Article ID: 58761, Effective: 2026-03-12 00:00:00, 851 covered, 0 non-covered
CPT 87594 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing D64.81.

8 policies

5 Medicare

Billing and Coding: Flow Cytometry
Policy ID: ART-56464
Billing and Coding: Erythropoiesis Stimulating Agents (ESAs)
Policy ID: ART-56795
Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
Policy ID: ART-58710
Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
Policy ID: ART-58720
Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
Policy ID: ART-58747

1 Aetna

Intravenous Iron Therapy
Policy ID: CPB-0575

CPT Codes Commonly Billed with D64.81

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

No procedure linkages on file for D64.81

We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.

Convert D64.81 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
D64.81 2853 00000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 D64.81, Billing FAQ

Is ICD-10 code D64.81 billable? +

Yes, D64.81 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What other names or terms map to D64.81? +

ICD-10 D64.81 includes: Antineoplastic chemotherapy induced anemia.

What codes are Type 2 Excludes for D64.81? +

Type 2 Excludes (may be coded together when both conditions exist): anemia in neoplastic disease (D63.0); aplastic anemia due to antineoplastic chemotherapy (D61.1)

What ICD-9 codes does D64.81 map to? +

Per CMS GEMs, D64.81 maps to ICD-9 codes: 2853. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on June 1, 2026.

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