ICD-10 D48.5
Billable / SpecificNeoplasm of uncertain behavior of skin
About ICD-10-CM D48.5
ICD-10-CM code D48.5 represents Neoplasm of uncertain behavior of skin. This is a billable/specific code in the Neoplasms chapter (block D48). The 2026 edition of ICD-10-CM D48.5 became effective on October 1, 2025.
Inclusion Terms / Approximate Synonyms
Clinical terms and conditions classified under D48.5. Per CMS ICD-10-CM Tabular 2026.
- Neoplasm of uncertain behavior of anal margin
- Neoplasm of uncertain behavior of anal skin
- Neoplasm of uncertain behavior of perianal skin
- Neoplasm of uncertain behavior of skin of breast
Type 1 Excludes
Pure excludes, these codes can never be coded together with D48.5. The conditions are mutually exclusive (e.g., congenital vs acquired forms).
- neoplasm of uncertain behavior of anus NOS (D37.8)
- neoplasm of uncertain behavior of skin of genital organs (D39.8, D40.8)
- neoplasm of uncertain behavior of vermilion border of lip (D37.0)
Medicare LCD Coverage for D48.5
Local Coverage Determinations (LCDs) from CMS MACs that list D48.5 as a covered diagnosis.
Showing top 10 of 856 total . Click a CPT for full coverage scope.
Commercial Payer Coverage
Coverage policies from major commercial payers referencing D48.5.
1 Aetna
5 Medicare
CPT Codes Commonly Billed with D48.5
Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.
- 11102 Skin biopsy — uncertain neoplasm, seborrheic keratosis, nevi, cyst, mass Dermatology
- 11102 Tangential skin biopsy — uncertain neoplasm skin, actinic keratosis, melanocytic nevi, skin cancer, melanoma, psoriasis, discoid lupus, skin disorder, rash, seborrheic keratosis, benign neoplasm, dermatitis, prurigo, dermatitis herpetiformis Dermatology
- 11104 Punch biopsy skin — uncertain skin neoplasm, skin cancer, melanoma, nevi, psoriasis, lupus, connective tissue disorder, pemphigus, bullous pemphigoid Dermatology
- 11106 Incisional biopsy skin — uncertain neoplasm, skin cancer, melanoma, nevi, actinic keratosis, BCC/SCC by site Dermatology
- 0089U CMS LCD: Billing and Coding: MolDX: Pigmented Lesion Assay CMS LCD
- 0314U CMS LCD: Billing and Coding: MolDX: Molecular Assays for the Diagnosis of Cutaneous Melanoma CMS LCD
- 0090U CMS LCD: Billing and Coding: MolDX: Molecular Assays for the Diagnosis of Cutaneous Melanoma CMS LCD
Convert D48.5 to ICD-9-CM
Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.
| ICD-10 | ICD-9 | Mapping Flags |
|---|---|---|
| D48.5 | 2382 | 00000 |
Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).
Codes Adjacent To D48.5
Other codes in section D37-D48 (Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes).
ICD-10 D48.5, Billing FAQ
Is ICD-10 code D48.5 billable? +
Yes, D48.5 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.
What other names or terms map to D48.5? +
ICD-10 D48.5 includes: Neoplasm of uncertain behavior of anal margin; Neoplasm of uncertain behavior of anal skin; Neoplasm of uncertain behavior of perianal skin, and 1 more clinical synonyms.
What codes are Type 1 Excludes for D48.5? +
Type 1 Excludes (never code together with D48.5): neoplasm of uncertain behavior of anus NOS (D37.8); neoplasm of uncertain behavior of skin of genital organs (D39.8, D40.8); neoplasm of uncertain behavior of vermilion border of lip (D37.0)
What CPT codes are commonly billed with D48.5? +
Procedures frequently paired with D48.5 include: 11102, 11102, 11104, 11106, 0089U.
What ICD-9 codes does D48.5 map to? +
Per CMS GEMs, D48.5 maps to ICD-9 codes: 2382. Useful for legacy data review and historical claim analysis.
Get the full PayerReady toolkit
Free access to CPT/ICD-10 lookup, denial appeals, fee comparator, and claim auditing with credentialing enrollment.
Start free →Run this code through our claim audit tool
Check NCCI bundling, MUE limits, and modifier logic before submission.
Try the auditor →Did this page help?
Quick signal so we know what to improve.
If you want a code reference page that doesn't exist yet, email coding@payerready.com.
Tell us what's missing or wrong: coding@payerready.com. We respond within 5 business days.
Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on August 31, 2026.
Powered by 11K CPT · 98K ICD-10 · 860K MPFS rates · 4.5M NCCI edits · 9.5M NPIs. Our data methodology · About our coding team