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ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 D48.2

Billable / Specific

Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system

D48
Block
0
Synonyms
226
LCDs
18
Payer Policies
2
Linked CPTs

About ICD-10-CM D48.2

ICD-10-CM code D48.2 represents Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system. This is a billable/specific code in the Neoplasms chapter (block D48). The 2026 edition of ICD-10-CM D48.2 became effective on October 1, 2025.

Type 1 Excludes

Pure excludes, these codes can never be coded together with D48.2. The conditions are mutually exclusive (e.g., congenital vs acquired forms).

  • neoplasm of uncertain behavior of peripheral nerves of orbit (D48.7)

Medicare LCD Coverage for D48.2

Local Coverage Determinations (LCDs) from CMS MACs that list D48.2 as a covered diagnosis.

226 LCDs

Showing top 10 of 226 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 77402 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 77371 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 61797 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT G0339 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 77338 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 77432 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 61800 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 77372 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 77435 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 77407 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing D48.2.

18 policies

5 Medicare

Oral Anticancer Drugs - Policy Article
Policy ID: ART-52479
Oral Antiemetic Drugs (Replacement for Intravenous Antiemetics) - Policy Article
Policy ID: ART-52480
Billing and Coding: Biomarkers for Oncology
Policy ID: ART-52986
Billing and Coding: Erythropoiesis Stimulating Agents (ESA)
Policy ID: ART-56462
Billing and Coding: Flow Cytometry
Policy ID: ART-56464

1 Aetna

Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) of the Spine
Policy ID: CPB-0236

CPT Codes Commonly Billed with D48.2

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

2 linkages
  • 76882 CMS LCD: Billing and Coding: Nonvascular Extremity Ultrasound CMS LCD
  • 76881 CMS LCD: Billing and Coding: Nonvascular Extremity Ultrasound CMS LCD

Convert D48.2 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
D48.2 2381 10000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 D48.2, Billing FAQ

Is ICD-10 code D48.2 billable? +

Yes, D48.2 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What codes are Type 1 Excludes for D48.2? +

Type 1 Excludes (never code together with D48.2): neoplasm of uncertain behavior of peripheral nerves of orbit (D48.7)

What CPT codes are commonly billed with D48.2? +

Procedures frequently paired with D48.2 include: 76882, 76881.

What ICD-9 codes does D48.2 map to? +

Per CMS GEMs, D48.2 maps to ICD-9 codes: 2381. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on July 16, 2026.

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