ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 C78.80

Billable / Specific HCC v28: 8 CC

Secondary malignant neoplasm of unspecified digestive organ

C78
Block
0
Synonyms
94
LCDs
18
Payer Policies
0
Linked CPTs

About ICD-10-CM C78.80

ICD-10-CM code C78.80 represents Secondary malignant neoplasm of unspecified digestive organ. This is a billable/specific code in the chapter (block C78). The 2026 edition of ICD-10-CM C78.80 became effective on October 1, 2025.

Coding Tips for C78.80

Specialist guidance from the PayerReady Medical Coding Team. Specificity warnings, HCC capture rules, sequencing notes.

HCC capture: document with MEAT each year

C78.80 is a CMS-HCC v28 risk-adjustment code (category 8). To count for the patient Risk Adjustment Factor (RAF), document the diagnosis with MEAT language each calendar year: Monitored, Evaluated, Assessed, Treated. A diagnosis on the problem list alone does not satisfy CMS RADV audit standards. Include the diagnosis in the assessment with current status and current treatment plan.

Inpatient DRG impact: CC

C78.80 is designated CC for MS-DRG grouping. On inpatient claims, this code can shift the DRG to the with-CC variant when documented as a present-on-admission secondary diagnosis. Hospital CDI programs flag CC opportunities during chart review. Failure to capture this code may leave 30 to 80 percent of the inpatient stay revenue unrealized.

Medicare Advantage HCC Impact

CMS-HCC v28 (current)
Category 8
ESRD-HCC
Category 8
RxHCC (Part D)
Category 8

Capture this diagnosis annually for accurate risk adjustment. Missed HCC captures are the #1 revenue leak in Medicare Advantage risk programs.

Inpatient DRG Impact, CC

codes Secondary malignant neoplasm of unspecified digestive organ. As a Complication/Comorbidity (CC), this contributes to DRG severity adjustment when documented alongside the principal diagnosis.

Medicare LCD Coverage for C78.80

Local Coverage Determinations (LCDs) from CMS MACs that list C78.80 as a covered diagnosis.

94 LCDs

Showing top 10 of 94 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: MolDX: NRAS Genetic Testing
Article ID: 57581, Effective: 2023-07-27 00:00:00, 56 covered, 0 non-covered
CPT 81479 →
CMS LCD: Billing and Coding: MolDX: NRAS Genetic Testing
Article ID: 57581, Effective: 2023-07-27 00:00:00, 56 covered, 0 non-covered
CPT 81311 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64420 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 20561 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64415 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64447 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64448 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64416 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64405 →
CMS LCD: Billing and Coding: Peripheral Nerve Blocks
Article ID: 57452, Effective: 2025-10-01 00:00:00, 1570 covered, 0 non-covered
CPT 64454 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing C78.80.

18 policies

5 Medicare

Oral Antiemetic Drugs (Replacement for Intravenous Antiemetics) - Policy Article
Policy ID: ART-52480
Billing and Coding: MolDX: bioTheranostics Cancer TYPE ID� Update
Policy ID: ART-53101
Billing and Coding: MolDX: bioTheranostics Cancer TYPE ID�
Policy ID: ART-54188
Billing and Coding: MolDX: bioTheranostics Cancer TYPE ID� Update
Policy ID: ART-54386
Billing and Coding: MolDX: FDA-Approved KRAS Tests
Policy ID: ART-54472

1 Aetna

Magnetic Resonance Cholangiopancreatography
Policy ID: CPB-0384

CPT Codes Commonly Billed with C78.80

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

No procedure linkages on file for C78.80

We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.

Convert C78.80 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
C78.80 1978 10000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 C78.80, Billing FAQ

Is ICD-10 code C78.80 billable? +

Yes, C78.80 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

Does C78.80 affect Medicare Advantage HCC risk adjustment? +

Yes. C78.80 maps to CMS-HCC v28 category 8. Capture this diagnosis annually for accurate Medicare Advantage risk score.

Is C78.80 a CC or MCC for inpatient DRG? +

Yes, this code is designated as CC. Documenting as a secondary diagnosis on inpatient claims can shift the DRG to a higher-weighted category.

What ICD-9 codes does C78.80 map to? +

Per CMS GEMs, C78.80 maps to ICD-9 codes: 1978. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on May 31, 2026.

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