ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 C54.0

Billable / Specific HCC v28: 12

Malignant neoplasm of isthmus uteri

C54
Block
1
Synonyms
945
LCDs
53
Payer Policies
6
Linked CPTs

About ICD-10-CM C54.0

ICD-10-CM code C54.0 represents Malignant neoplasm of isthmus uteri. This is a billable/specific code in the chapter (block C54). The 2026 edition of ICD-10-CM C54.0 became effective on October 1, 2025.

Coding Tips for C54.0

Specialist guidance from the PayerReady Medical Coding Team. Specificity warnings, HCC capture rules, sequencing notes.

HCC capture: document with MEAT each year

C54.0 is a CMS-HCC v28 risk-adjustment code (category 12). To count for the patient Risk Adjustment Factor (RAF), document the diagnosis with MEAT language each calendar year: Monitored, Evaluated, Assessed, Treated. A diagnosis on the problem list alone does not satisfy CMS RADV audit standards. Include the diagnosis in the assessment with current status and current treatment plan.

Inclusion Terms / Approximate Synonyms

Clinical terms and conditions classified under C54.0. Per CMS ICD-10-CM Tabular 2026.

  • Malignant neoplasm of lower uterine segment

Medicare Advantage HCC Impact

CMS-HCC v28 (current)
Category 12
ESRD-HCC
Category 12
RxHCC (Part D)
Category 12

Capture this diagnosis annually for accurate risk adjustment. Missed HCC captures are the #1 revenue leak in Medicare Advantage risk programs.

Medicare LCD Coverage for C54.0

Local Coverage Determinations (LCDs) from CMS MACs that list C54.0 as a covered diagnosis.

945 LCDs

Showing top 10 of 945 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 77402 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 77371 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 61797 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT G0339 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 77338 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 77432 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 61800 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 77372 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 77435 →
CMS LCD: Billing and Coding: Radiation Therapies
Article ID: 59350, Effective: 2026-01-01 00:00:00, 757 covered, 0 non-covered
CPT 77407 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing C54.0.

53 policies

5 Medicare

Billing and Coding: Bevacizumab and biosimilars
Policy ID: ART-52370
Billing and Coding: Paclitaxel (e.g., Taxol�/Abraxane �)
Policy ID: ART-52450
Oral Anticancer Drugs - Policy Article
Policy ID: ART-52479
Oral Antiemetic Drugs (Replacement for Intravenous Antiemetics) - Policy Article
Policy ID: ART-52480
Billing and Coding: Biomarkers for Oncology
Policy ID: ART-52986

CPT Codes Commonly Billed with C54.0

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

6 linkages
  • C9726 CMS LCD: Billing and Coding: Intraoperative Radiation Therapy CMS LCD
  • 19294 CMS LCD: Billing and Coding: Intraoperative Radiation Therapy CMS LCD
  • 76145 CMS LCD: Billing and Coding: Intraoperative Radiation Therapy CMS LCD
  • 77469 CMS LCD: Billing and Coding: Intraoperative Radiation Therapy CMS LCD
  • 77425 CMS LCD: Billing and Coding: Intraoperative Radiation Therapy CMS LCD
  • 77424 CMS LCD: Billing and Coding: Intraoperative Radiation Therapy CMS LCD

Convert C54.0 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
C54.0 1821 00000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 C54.0, Billing FAQ

Is ICD-10 code C54.0 billable? +

Yes, C54.0 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What other names or terms map to C54.0? +

ICD-10 C54.0 includes: Malignant neoplasm of lower uterine segment.

Does C54.0 affect Medicare Advantage HCC risk adjustment? +

Yes. C54.0 maps to CMS-HCC v28 category 12. Capture this diagnosis annually for accurate Medicare Advantage risk score.

What CPT codes are commonly billed with C54.0? +

Procedures frequently paired with C54.0 include: C9726, 19294, 76145, 77469, 77425.

What ICD-9 codes does C54.0 map to? +

Per CMS GEMs, C54.0 maps to ICD-9 codes: 1821. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on May 31, 2026.

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