ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 C50.921

Billable / Specific HCC v28: 12

Malignant neoplasm of unspecified site of right male breast

C50
Block
0
Synonyms
1,350
LCDs
72
Payer Policies
35
Linked CPTs

About ICD-10-CM C50.921

ICD-10-CM code C50.921 represents Malignant neoplasm of unspecified site of right male breast. This is a billable/specific code in the chapter (block C50). The 2026 edition of ICD-10-CM C50.921 became effective on October 1, 2025.

Coding Tips for C50.921

Specialist guidance from the PayerReady Medical Coding Team. Specificity warnings, HCC capture rules, sequencing notes.

HCC capture: document with MEAT each year

C50.921 is a CMS-HCC v28 risk-adjustment code (category 12). To count for the patient Risk Adjustment Factor (RAF), document the diagnosis with MEAT language each calendar year: Monitored, Evaluated, Assessed, Treated. A diagnosis on the problem list alone does not satisfy CMS RADV audit standards. Include the diagnosis in the assessment with current status and current treatment plan.

Medicare Advantage HCC Impact

CMS-HCC v28 (current)
Category 12
ESRD-HCC
Category 12
RxHCC (Part D)
Category 12

Capture this diagnosis annually for accurate risk adjustment. Missed HCC captures are the #1 revenue leak in Medicare Advantage risk programs.

Medicare LCD Coverage for C50.921

Local Coverage Determinations (LCDs) from CMS MACs that list C50.921 as a covered diagnosis.

1,350 LCDs

Showing top 10 of 1,350 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74170 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74177 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74160 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74178 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74150 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 72194 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 74176 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 72192 →
CMS LCD: Billing and Coding: CT of the Abdomen and Pelvis
Article ID: 56421, Effective: 2025-11-01 00:00:00, 5389 covered, 0 non-covered
CPT 72193 →
CMS LCD: Billing and Coding: MolDX: Non-Next Generation Sequencing Targeted Molecular Panel Tests for Predictive Testing in Cancer
Article ID: 60240, Effective: , 680 covered, 0 non-covered
CPT 81479 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing C50.921.

72 policies

2 Cigna

Transthoracic Echocardiography in Adults - (0510)
Policy ID: MM_0510
Transthoracic Echocardiography in Children - (0523)
Policy ID: MM_0523

5 Medicare

Billing and Coding: Bevacizumab and biosimilars
Policy ID: ART-52370
Billing and Coding: Paclitaxel (e.g., Taxol�/Abraxane �)
Policy ID: ART-52450
Billing and Coding: Luteinizing Hormone-Releasing Hormone (LHRH) Analogs
Policy ID: ART-52453
Oral Anticancer Drugs - Policy Article
Policy ID: ART-52479
Oral Antiemetic Drugs (Replacement for Intravenous Antiemetics) - Policy Article
Policy ID: ART-52480

CPT Codes Commonly Billed with C50.921

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

35 linkages
  • J1952 CMS LCD: Billing and Coding: Luteinizing Hormone-Releasing Hormone (LHRH) Analogs CMS LCD
  • J3316 CMS LCD: Billing and Coding: Luteinizing Hormone-Releasing Hormone (LHRH) Analogs CMS LCD
  • 96402 CMS LCD: Billing and Coding: Luteinizing Hormone-Releasing Hormone (LHRH) Analogs CMS LCD
  • J9219 CMS LCD: Billing and Coding: Luteinizing Hormone-Releasing Hormone (LHRH) Analogs CMS LCD
  • J9225 CMS LCD: Billing and Coding: Luteinizing Hormone-Releasing Hormone (LHRH) Analogs CMS LCD
  • J9218 CMS LCD: Billing and Coding: Luteinizing Hormone-Releasing Hormone (LHRH) Analogs CMS LCD
  • J1950 CMS LCD: Billing and Coding: Luteinizing Hormone-Releasing Hormone (LHRH) Analogs CMS LCD
  • J1954 CMS LCD: Billing and Coding: Luteinizing Hormone-Releasing Hormone (LHRH) Analogs CMS LCD
  • 11983 CMS LCD: Billing and Coding: Luteinizing Hormone-Releasing Hormone (LHRH) Analogs CMS LCD
  • 11982 CMS LCD: Billing and Coding: Luteinizing Hormone-Releasing Hormone (LHRH) Analogs CMS LCD

Convert C50.921 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
C50.921 1759 10000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 C50.921, Billing FAQ

Is ICD-10 code C50.921 billable? +

Yes, C50.921 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

Does C50.921 affect Medicare Advantage HCC risk adjustment? +

Yes. C50.921 maps to CMS-HCC v28 category 12. Capture this diagnosis annually for accurate Medicare Advantage risk score.

What CPT codes are commonly billed with C50.921? +

Procedures frequently paired with C50.921 include: J1952, J3316, 96402, J9219, J9225.

What ICD-9 codes does C50.921 map to? +

Per CMS GEMs, C50.921 maps to ICD-9 codes: 1759. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on June 1, 2026.

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