ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 C50.219

Billable / Specific HCC v28: 12

Malignant neoplasm of upper-inner quadrant of unspecified female breast

C50
Block
0
Synonyms
976
LCDs
48
Payer Policies
2
Linked CPTs

About ICD-10-CM C50.219

ICD-10-CM code C50.219 represents Malignant neoplasm of upper-inner quadrant of unspecified female breast. This is a billable/specific code in the chapter (block C50). The 2026 edition of ICD-10-CM C50.219 became effective on October 1, 2025.

Coding Tips for C50.219

Specialist guidance from the PayerReady Medical Coding Team. Specificity warnings, HCC capture rules, sequencing notes.

HCC capture: document with MEAT each year

C50.219 is a CMS-HCC v28 risk-adjustment code (category 12). To count for the patient Risk Adjustment Factor (RAF), document the diagnosis with MEAT language each calendar year: Monitored, Evaluated, Assessed, Treated. A diagnosis on the problem list alone does not satisfy CMS RADV audit standards. Include the diagnosis in the assessment with current status and current treatment plan.

Medicare Advantage HCC Impact

CMS-HCC v28 (current)
Category 12
ESRD-HCC
Category 12
RxHCC (Part D)
Category 12

Capture this diagnosis annually for accurate risk adjustment. Missed HCC captures are the #1 revenue leak in Medicare Advantage risk programs.

Medicare LCD Coverage for C50.219

Local Coverage Determinations (LCDs) from CMS MACs that list C50.219 as a covered diagnosis.

976 LCDs

Showing top 10 of 976 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: MolDX: Non-Next Generation Sequencing Targeted Molecular Panel Tests for Predictive Testing in Cancer
Article ID: 60240, Effective: , 680 covered, 0 non-covered
CPT 81479 →
CMS LCD: Billing and Coding: MolDX: Non-Next Generation Sequencing Targeted Molecular Panel Tests for Predictive Testing in Cancer
Article ID: 60309, Effective: , 680 covered, 0 non-covered
CPT 81479 →
CMS LCD: Billing and Coding: MolDX: Phenotypic Biomarker Detection from Circulating Tumor Cells
Article ID: 58063, Effective: 2023-11-16 00:00:00, 90 covered, 0 non-covered
CPT 81479 →
CMS LCD: Billing and Coding: MolDX: Plasma-Based Genomic Profiling in Solid Tumors
Article ID: 57867, Effective: 2025-07-01 00:00:00, 622 covered, 0 non-covered
CPT 0179U →
CMS LCD: Billing and Coding: MolDX: Plasma-Based Genomic Profiling in Solid Tumors
Article ID: 57867, Effective: 2025-07-01 00:00:00, 622 covered, 0 non-covered
CPT 81479 →
CMS LCD: Billing and Coding: MolDX: Plasma-Based Genomic Profiling in Solid Tumors
Article ID: 57867, Effective: 2025-07-01 00:00:00, 622 covered, 0 non-covered
CPT 81462 →
CMS LCD: Billing and Coding: MolDX: Plasma-Based Genomic Profiling in Solid Tumors
Article ID: 57867, Effective: 2025-07-01 00:00:00, 622 covered, 0 non-covered
CPT 81445 →
CMS LCD: Billing and Coding: MolDX: Plasma-Based Genomic Profiling in Solid Tumors
Article ID: 57867, Effective: 2025-07-01 00:00:00, 622 covered, 0 non-covered
CPT 0571U →
CMS LCD: Billing and Coding: MolDX: Plasma-Based Genomic Profiling in Solid Tumors
Article ID: 57867, Effective: 2025-07-01 00:00:00, 622 covered, 0 non-covered
CPT 0485U →
CMS LCD: Billing and Coding: MolDX: Plasma-Based Genomic Profiling in Solid Tumors
Article ID: 57867, Effective: 2025-07-01 00:00:00, 622 covered, 0 non-covered
CPT 81463 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing C50.219.

48 policies

5 Medicare

Billing and Coding: Bevacizumab and biosimilars
Policy ID: ART-52370
Billing and Coding: Paclitaxel (e.g., Taxol�/Abraxane �)
Policy ID: ART-52450
External Breast Prostheses - Policy Article
Policy ID: ART-52478
Oral Anticancer Drugs - Policy Article
Policy ID: ART-52479
Billing and Coding: MolDX: Oncotype DX� Breast Cancer Assay
Policy ID: ART-53105

CPT Codes Commonly Billed with C50.219

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

2 linkages
  • 0155U CMS LCD: Billing and Coding: MolDX: PIK3CA Gene Tests CMS LCD
  • 81309 CMS LCD: Billing and Coding: MolDX: PIK3CA Gene Tests CMS LCD

Convert C50.219 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
C50.219 1742 10000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 C50.219, Billing FAQ

Is ICD-10 code C50.219 billable? +

Yes, C50.219 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

Does C50.219 affect Medicare Advantage HCC risk adjustment? +

Yes. C50.219 maps to CMS-HCC v28 category 12. Capture this diagnosis annually for accurate Medicare Advantage risk score.

What CPT codes are commonly billed with C50.219? +

Procedures frequently paired with C50.219 include: 0155U, 81309.

What ICD-9 codes does C50.219 map to? +

Per CMS GEMs, C50.219 maps to ICD-9 codes: 1742. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on May 31, 2026.

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