ICD-10-CM 2026 · Effective October 1, 2025

ICD-10 A48.3

Billable / Specific HCC v28: 2 MCC

Toxic shock syndrome

A48
Block
0
Synonyms
25
LCDs
3
Payer Policies
0
Linked CPTs

About ICD-10-CM A48.3

ICD-10-CM code A48.3 represents Toxic shock syndrome. This is a billable/specific code in the Infectious and Parasitic Diseases chapter (block A48). The 2026 edition of ICD-10-CM A48.3 became effective on October 1, 2025.

Coding Tips for A48.3

Specialist guidance from the PayerReady Medical Coding Team. Specificity warnings, HCC capture rules, sequencing notes.

HCC capture: document with MEAT each year

A48.3 is a CMS-HCC v28 risk-adjustment code (category 2). To count for the patient Risk Adjustment Factor (RAF), document the diagnosis with MEAT language each calendar year: Monitored, Evaluated, Assessed, Treated. A diagnosis on the problem list alone does not satisfy CMS RADV audit standards. Include the diagnosis in the assessment with current status and current treatment plan.

Inpatient DRG impact: MCC

A48.3 is designated MCC for MS-DRG grouping. On inpatient claims, this code can shift the DRG to the with-MCC variant when documented as a present-on-admission secondary diagnosis. Hospital CDI programs flag MCC opportunities during chart review. Failure to capture this code may leave 30 to 80 percent of the inpatient stay revenue unrealized.

Type 1 Excludes

Pure excludes, these codes can never be coded together with A48.3. The conditions are mutually exclusive (e.g., congenital vs acquired forms).

  • endotoxic shock NOS (R57.8)
  • sepsis NOS (A41.9)

Use Additional Code

When coding A48.3, also report these additional codes when applicable.

  • code to identify the organism (B95, B96)

Medicare Advantage HCC Impact

CMS-HCC v28 (current)
Category 2
ESRD-HCC
Category 2
RxHCC (Part D)
Category 2

Capture this diagnosis annually for accurate risk adjustment. Missed HCC captures are the #1 revenue leak in Medicare Advantage risk programs.

Inpatient DRG Impact, MCC

codes Toxic shock syndrome. As a Major Complication/Comorbidity (MCC), this can shift the DRG assignment to a higher-weighted category, substantial reimbursement impact.

Medicare LCD Coverage for A48.3

Local Coverage Determinations (LCDs) from CMS MACs that list A48.3 as a covered diagnosis.

25 LCDs

Showing top 10 of 25 total . Click a CPT for full coverage scope.

CMS LCD: Billing and Coding: Off-Label Use of Intravenous Immune Globulin (IVIG)
Article ID: 60187, Effective: , 301 covered, 0 non-covered
CPT J1561 →
CMS LCD: Billing and Coding: Off-Label Use of Intravenous Immune Globulin (IVIG)
Article ID: 60187, Effective: , 301 covered, 0 non-covered
CPT J1556 →
CMS LCD: Billing and Coding: Off-Label Use of Intravenous Immune Globulin (IVIG)
Article ID: 60187, Effective: , 301 covered, 0 non-covered
CPT J1566 →
CMS LCD: Billing and Coding: Off-Label Use of Intravenous Immune Globulin (IVIG)
Article ID: 60187, Effective: , 301 covered, 0 non-covered
CPT J1576 →
CMS LCD: Billing and Coding: Off-Label Use of Intravenous Immune Globulin (IVIG)
Article ID: 60187, Effective: , 301 covered, 0 non-covered
CPT J1554 →
CMS LCD: Billing and Coding: Off-Label Use of Intravenous Immune Globulin (IVIG)
Article ID: 60187, Effective: , 301 covered, 0 non-covered
CPT J1557 →
CMS LCD: Billing and Coding: Off-Label Use of Intravenous Immune Globulin (IVIG)
Article ID: 60187, Effective: , 301 covered, 0 non-covered
CPT J1568 →
CMS LCD: Billing and Coding: Off-Label Use of Intravenous Immune Globulin (IVIG)
Article ID: 60187, Effective: , 301 covered, 0 non-covered
CPT J1599 →
CMS LCD: Billing and Coding: Off-Label Use of Intravenous Immune Globulin (IVIG)
Article ID: 60187, Effective: , 301 covered, 0 non-covered
CPT J1459 →
CMS LCD: Billing and Coding: Off-Label Use of Intravenous Immune Globulin (IVIG)
Article ID: 60187, Effective: , 301 covered, 0 non-covered
CPT J1572 →

Commercial Payer Coverage

Coverage policies from major commercial payers referencing A48.3.

3 policies

2 Medicare

Billing and Coding: Off-Label Use of Intravenous Immune Globulin (IVIG)
Policy ID: ART-59105
Billing and Coding: Off-Label Use of Intravenous Immune Globulin (IVIG)
Policy ID: ART-60187

1 Aetna

Parenteral Immunoglobulins
Policy ID: CPB-0206

CPT Codes Commonly Billed with A48.3

Procedures frequently paired with this diagnosis based on PayerReady's Dx↔Px linkage data.

No procedure linkages on file for A48.3

We don't have CPT pairings indexed for this specific code yet. Use the CPT search above to find common procedures, or check your payer's published medical policy for code-specific guidance.

Convert A48.3 to ICD-9-CM

Per CMS General Equivalence Mappings (GEMs), useful for legacy data review and historical claim analysis.

ICD-10ICD-9Mapping Flags
A48.3 04082 00000

Flags format (5 digits): Approximate · No Map · Combination · Scenario · Choice List. Source: CMS 2017 GEMs (final version).

ICD-10 A48.3, Billing FAQ

Is ICD-10 code A48.3 billable? +

Yes, A48.3 is a billable ICD-10-CM code that can appear as a primary or secondary diagnosis on claims.

What codes are Type 1 Excludes for A48.3? +

Type 1 Excludes (never code together with A48.3): endotoxic shock NOS (R57.8); sepsis NOS (A41.9)

Does A48.3 affect Medicare Advantage HCC risk adjustment? +

Yes. A48.3 maps to CMS-HCC v28 category 2. Capture this diagnosis annually for accurate Medicare Advantage risk score.

Is A48.3 a CC or MCC for inpatient DRG? +

Yes, this code is designated as MCC. Documenting as a secondary diagnosis on inpatient claims can shift the DRG to a higher-weighted category.

What ICD-9 codes does A48.3 map to? +

Per CMS GEMs, A48.3 maps to ICD-9 codes: 04082. Useful for legacy data review and historical claim analysis.

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Reviewed by the PayerReady Medical Coding Team

Verified against the CMS 2026 code set on May 31, 2026.

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