CPT 64901
Global ZZZ ActiveNerve graft add-on
CPT 64901 Billing & Documentation Guide
CPT code 64901 (Nerve graft add-on) is classified under Surgery (Endocrine/Nervous/Eye/Ear) with a global period indicator of ZZZ. The 2026 Medicare Physician Fee Schedule assigns a work RVU of 9.95, a non-facility practice expense RVU of 3.17, and a malpractice RVU of 2.12, a total non-facility RVU of 15.24 and facility RVU of 15.24. With the current conversion factor of $33.4009, the national average non-facility reimbursement is approximately $510.24, though rates vary from $455.58 to $650.29 based on MAC locality and Geographic Practice Cost Indices (GPCIs).
When billing 64901, ensure documentation supports medical necessity and the specific components required for the code's level of service. For E/M codes, document MDM (medical decision-making) elements: problems addressed, data reviewed, and risk. For procedural codes, document the indication, technique, and any complications. Always verify NCCI edits before bundling 64901 with related codes; this code has 10 PTP bundling relationships on file (see table below).
Payment Status & Global Period
Active code (paid under MPFS)
Add-on code (global concept does not apply)
MUE Limit (Medically Unlikely Edits)
Submitting more than 2 units of 64901 for the same patient on the same date triggers automatic line denial unless an appropriate modifier and supporting documentation justify the higher quantity.
RVU Breakdown, CPT 64901
| Component | Non-Facility | Facility |
|---|---|---|
| Work RVU | 9.95 | 9.95 |
| Practice Expense RVU | 3.17 | 3.17 |
| Malpractice RVU | 2.12 | 2.12 |
| Total RVU | 15.24 | 15.24 |
| Conversion Factor | $33.4009 | |
2026 Medicare Reimbursement by State, CPT 64901
State-level averages across all MAC localities. Non-facility rates typically apply to office-based services; facility rates apply to hospital outpatient / inpatient.
| State | Non-Facility | Facility | Range (Non-Fac) | Localities |
|---|---|---|---|---|
| California | $507.94 | $507.94 | $491.99 - $559.53 | 29 |
| Florida | $576.42 | $576.42 | $539.99 - $621.64 | 3 |
| Georgia | $518.57 | $518.57 | $511.19 - $525.95 | 2 |
| Illinois | $571.13 | $571.13 | $539.68 - $603.58 | 4 |
| Michigan | $531.43 | $531.43 | $508.95 - $553.9 | 2 |
| North Carolina | $476.37 | $476.37 | $476.37 - $476.37 | 1 |
| New York | $562.49 | $562.49 | $482.71 - $610.99 | 5 |
| Ohio | $500.38 | $500.38 | $500.38 - $500.38 | 1 |
| Pennsylvania | $514.74 | $514.74 | $496.45 - $533.02 | 2 |
| Texas | $504.18 | $504.18 | $494.47 - $537.57 | 8 |
Source: CMS PFSRVU 2026 · Updated 2026-04-01. Full locality-level detail available for all 53 states, contact us for custom reports.
NCCI Bundling Edits, CPT 64901
Procedure-to-procedure (PTP) edits. If you bill any of these codes with 64901 on the same date of service, review the modifier indicator and payer policy before submission.
| Partner Code | Relationship | Modifier Allowed | Rationale |
|---|---|---|---|
| 0333T | Column 1 (primary), can be billed with modifier | No | CPT Manual or CMS manual coding instruction |
| 0464T | Column 1 (primary), can be billed with modifier | No | CPT Manual or CMS manual coding instruction |
| 0490T | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
| 0718T | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
| 20527 | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
| 20550 | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
| 20551 | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
| 20552 | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
| 20553 | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
| 20560 | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
Frequently Asked Questions, CPT 64901
What does CPT code 64901 mean? +
CPT code 64901 represents: Nerve graft add-on. It's in the Surgery (Endocrine/Nervous/Eye/Ear) category with a global period of ZZZ.
What is the Medicare reimbursement for CPT 64901? +
The 2026 Medicare national average non-facility payment for CPT 64901 is $510.24. Rates range from $455.58 to $650.29 across 53 states depending on MAC locality and GPCIs.
What modifiers can I use with CPT 64901? +
Surgery codes commonly use modifier 22 (increased procedural services), 50 (bilateral), 51 (multiple procedures), 52 (reduced services), 58/78/79 (staged, unplanned return, unrelated within global), 62 (co-surgeons), 80/82 (assistant surgeon), and 59 or the X{EPSU} subset for distinct procedural service.
What bundling edits apply to CPT 64901? +
This code has 10 NCCI PTP bundling relationships. See the NCCI Bundling section below for full list.
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on April 17, 2026.
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