CPT 52648
Global 090 ActiveLaser surgery of prostate
CPT 52648 Billing & Documentation Guide
CPT code 52648 (Laser surgery of prostate) is classified under Surgery (Urinary/Reproductive) with a global period indicator of 090. The 2026 Medicare Physician Fee Schedule assigns a work RVU of 9.8, a non-facility practice expense RVU of 4.75, and a malpractice RVU of 1.27, a total non-facility RVU of 15.82 and facility RVU of 15.82. With the current conversion factor of $33.4009, the national average non-facility reimbursement is approximately $535.91, though rates vary from $485.46 to $683.33 based on MAC locality and Geographic Practice Cost Indices (GPCIs).
When billing 52648, ensure documentation supports medical necessity and the specific components required for the code's level of service. For E/M codes, document MDM (medical decision-making) elements: problems addressed, data reviewed, and risk. For procedural codes, document the indication, technique, and any complications. Always verify NCCI edits before bundling 52648 with related codes; this code has 10 PTP bundling relationships on file (see table below).
Payment Status & Global Period
Active code (paid under MPFS)
90-day global period (major surgery: 1 day pre-op + procedure + 90 days post-op)
MUE Limit (Medically Unlikely Edits)
Submitting more than 1 units of 52648 for the same patient on the same date triggers automatic line denial unless an appropriate modifier and supporting documentation justify the higher quantity.
RVU Breakdown, CPT 52648
| Component | Non-Facility | Facility |
|---|---|---|
| Work RVU | 9.8 | 9.8 |
| Practice Expense RVU | 4.75 | 4.75 |
| Malpractice RVU | 1.27 | 1.27 |
| Total RVU | 15.82 | 15.82 |
| Conversion Factor | $33.4009 | |
2026 Medicare Reimbursement by State, CPT 52648
State-level averages across all MAC localities. Non-facility rates typically apply to office-based services; facility rates apply to hospital outpatient / inpatient.
| State | Non-Facility | Facility | Range (Non-Fac) | Localities |
|---|---|---|---|---|
| California | $549.8 | $549.8 | $529.52 - $614.85 | 29 |
| Florida | $569.09 | $569.09 | $542.76 - $599.77 | 3 |
| Georgia | $529.93 | $529.93 | $519.41 - $540.45 | 2 |
| Illinois | $562.84 | $562.84 | $538.48 - $586.42 | 4 |
| Michigan | $536.01 | $536.01 | $520.07 - $551.95 | 2 |
| North Carolina | $502.46 | $502.46 | $502.46 - $502.46 | 1 |
| New York | $577.51 | $577.51 | $507.87 - $615.69 | 5 |
| Ohio | $514.94 | $514.94 | $514.94 - $514.94 | 1 |
| Pennsylvania | $531.03 | $531.03 | $513.06 - $548.99 | 2 |
| Texas | $524.73 | $524.73 | $511.11 - $545.86 | 8 |
Source: CMS PFSRVU 2026 · Updated 2026-04-01. Full locality-level detail available for all 53 states, contact us for custom reports.
NCCI Bundling Edits, CPT 52648
Procedure-to-procedure (PTP) edits. If you bill any of these codes with 52648 on the same date of service, review the modifier indicator and payer policy before submission.
| Partner Code | Relationship | Modifier Allowed | Rationale |
|---|---|---|---|
| 00910 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 00914 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 00916 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 0137T | Column 1 (primary), can be billed with modifier | Yes | Standards of medical/surgical practice |
| 0213T | Column 1 (primary), can be billed with modifier | No | Misuse of Column Two code with Column One code |
| 0216T | Column 1 (primary), can be billed with modifier | No | Misuse of Column Two code with Column One code |
| 0228T | Column 1 (primary), can be billed with modifier | No | Standards of medical/surgical practice |
| 0230T | Column 1 (primary), can be billed with modifier | No | Standards of medical/surgical practice |
| 0403U | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
| 0421T | Column 1 (primary), can be billed with modifier | No | Mutually exclusive procedures |
Frequently Asked Questions, CPT 52648
What does CPT code 52648 mean? +
CPT code 52648 represents: Laser surgery of prostate. It's in the Surgery (Urinary/Reproductive) category with a global period of 090.
What is the Medicare reimbursement for CPT 52648? +
The 2026 Medicare national average non-facility payment for CPT 52648 is $535.91. Rates range from $485.46 to $683.33 across 53 states depending on MAC locality and GPCIs.
What modifiers can I use with CPT 52648? +
Surgery codes commonly use modifier 22 (increased procedural services), 50 (bilateral), 51 (multiple procedures), 52 (reduced services), 58/78/79 (staged, unplanned return, unrelated within global), 62 (co-surgeons), 80/82 (assistant surgeon), and 59 or the X{EPSU} subset for distinct procedural service.
What bundling edits apply to CPT 52648? +
This code has 10 NCCI PTP bundling relationships. See the NCCI Bundling section below for full list.
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on May 31, 2026.
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